Pleomorphic Primitive Neuroectodermal Tumor with Glial and Neuronal Differentiation: Clinical, Pathological, Cultural, and Chromosomal Analysis of a Case View Full Text


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Article Info

DATE

2002-08

AUTHORS

Yuji Uematsu, Rie Takehara, Mina Shimizu, Yoshiyuki Tanaka, Toru Itakura, Norihiko Komai

ABSTRACT

This paper examines a case of pleomorphic primitive neuroectodermal tumor (PNET) with glial and neuronal differentiation in a 7-year-old girl who was clinicopathologically reported with immunohistochemical and chromosomal analysis. Clinically, a highly aggressive behavior leading to early recurrence with cerebrospinal fluid seedings was characteristic despite total removal and chemoradiation therapy. Pathologically, severe pleomorphism was noted and large ganglioid cells were predominant. Immunohistochemically, the expression of low-molecular neurofilament was recognized in the surgical specimens and increased in the recurrence. Coexpression of vimentin and neurofilament/GFAP was recognized in the culture. Chromosomal analysis showed near-diploidy, but different karyotype from that PNETs previously reported. These findings suggested that PNETs with pleomorphism and differentiation into both glial and neuronal lineages may show aggressiveness and require more aggressive therapy. More... »

PAGES

71-79

References to SciGraph publications

  • 1988-11. Cerebral primitive neuroectodermal tumors in childhood in JOURNAL OF NEURO-ONCOLOGY
  • 1996-07. Suprateutorial primitive neuroectodermal tumors in children in JOURNAL OF NEURO-ONCOLOGY
  • 1985-03. Primitive neuroectodermal tumours of the cerebrum in JOURNAL OF NEURO-ONCOLOGY
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1023/a:1016321030590

    DOI

    http://dx.doi.org/10.1023/a:1016321030590

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12222841


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