Molecular Mobility of Amorphous Pharmaceutical Solids Below Their Glass Transition Temperatures View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-06

AUTHORS

Bruno C. Hancock, Sheri L. Shamblin, George Zografi

ABSTRACT

PURPOSE: To measure the molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures (Tg), using indomethacin, poly (vinyl pyrrolidone) (PVP) and sucrose as model compounds. METHODS: Differential scanning calorimetry (DSC) was used to measure enthalpic relaxation of the amorphous samples after storage at temperatures 16-47 K below Tg for various time periods. The measured enthalpy changes were used to calculate molecular relaxation time parameters. Analogous changes in specimen dimensions were measured for PVP films using thermomechanical analysis. RESULTS: For all the model materials it was necessary to cool to at least 50 K below the experimental Tg before the molecular motions detected by DSC could be considered to be negligible over the lifetime of a typical pharmaceutical product. In each case the temperature dependence of the molecular motions below Tg was less than that typically reported above Tg and was rapidly changing. CONCLUSIONS: In the temperature range studied the model amorphous solids were in a transition zone between regions of very high molecular mobility above Tg and very low molecular mobility much further below Tg. In general glassy pharmaceutical solids should be expected to experience significant molecular mobility at temperatures up to fifty degrees below their glass transition temperature. More... »

PAGES

799-806

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1016292416526

DOI

http://dx.doi.org/10.1023/a:1016292416526

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052847671

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7667182


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0307", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Theoretical and Computational Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calorimetry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemistry, Pharmaceutical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crystallization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glass", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Indomethacin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Chemical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Structure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sucrose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Temperature", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "School of Pharmacy, University of Wisconsin-Madison, 53706, Madison, Wisconsin"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hancock", 
        "givenName": "Bruno C.", 
        "id": "sg:person.0636134005.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636134005.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "School of Pharmacy, University of Wisconsin-Madison, 53706, Madison, Wisconsin"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shamblin", 
        "givenName": "Sheri L.", 
        "id": "sg:person.0674545256.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674545256.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "School of Pharmacy, University of Wisconsin-Madison, 53706, Madison, Wisconsin"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zografi", 
        "givenName": "George", 
        "id": "sg:person.0100561403.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0100561403.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1039/tf9706600080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000572480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/polb.1994.090320312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004213909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0260-8774(94)90028-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006875439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0260-8774(94)90028-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006875439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1018988506336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010235358", 
          "https://doi.org/10.1023/a:1018988506336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jps.2600830337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013943728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5173(94)90219-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018372208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5173(94)90219-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018372208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/0953-8984/6/28/006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020108276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jps.2600831211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031087388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.37.2782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037646836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0032-3861(93)90741-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040895300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0032-3861(93)90741-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040895300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rspa.1966.0138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044798096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr60135a002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053927957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/j100619a008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055674247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja01619a008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055813183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ma00047a030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056174630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.1744141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057806582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.466117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058044123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1557/proc-215-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067917921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1557/proc-215-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067917939"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1995-06", 
    "datePublishedReg": "1995-06-01", 
    "description": "PURPOSE: To measure the molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures (Tg), using indomethacin, poly (vinyl pyrrolidone) (PVP) and sucrose as model compounds.\nMETHODS: Differential scanning calorimetry (DSC) was used to measure enthalpic relaxation of the amorphous samples after storage at temperatures 16-47 K below Tg for various time periods. The measured enthalpy changes were used to calculate molecular relaxation time parameters. Analogous changes in specimen dimensions were measured for PVP films using thermomechanical analysis.\nRESULTS: For all the model materials it was necessary to cool to at least 50 K below the experimental Tg before the molecular motions detected by DSC could be considered to be negligible over the lifetime of a typical pharmaceutical product. In each case the temperature dependence of the molecular motions below Tg was less than that typically reported above Tg and was rapidly changing.\nCONCLUSIONS: In the temperature range studied the model amorphous solids were in a transition zone between regions of very high molecular mobility above Tg and very low molecular mobility much further below Tg. In general glassy pharmaceutical solids should be expected to experience significant molecular mobility at temperatures up to fifty degrees below their glass transition temperature.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1023/a:1016292416526", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094644", 
        "issn": [
          "0724-8741", 
          "1573-904X"
        ], 
        "name": "Pharmaceutical Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Molecular Mobility of Amorphous Pharmaceutical Solids Below Their Glass Transition Temperatures", 
    "pagination": "799-806", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fbba75dd7e98bb141cb564682209db17662f26e971586486b69426f6f3a23220"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7667182"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8406521"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1016292416526"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1052847671"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1016292416526", 
      "https://app.dimensions.ai/details/publication/pub.1052847671"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000508.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1023/A:1016292416526"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1016292416526'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1016292416526'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1016292416526'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1016292416526'


 

This table displays all metadata directly associated to this object as RDF triples.

181 TRIPLES      21 PREDICATES      58 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1016292416526 schema:about N2e3a767e37494b249558da70aeffebcb
2 N36892cf2cbd04e668ee81aa069c75475
3 N476fc0bc5ccb4c1382527a371516a92e
4 N53865a807c214dcebba20fe188aea497
5 N735a8a8d798744cc87b69ae9717db30a
6 N84c735637a314036bed57149e3a5adbf
7 N8758bc0608284eab830489fdf7179c14
8 Naa411c20595b440c875cd2f24743dfa3
9 Nb1d3364b7d264641905ad19f9e323052
10 Ncd32cb5b78fc46d7973c6ae345f3003d
11 anzsrc-for:03
12 anzsrc-for:0307
13 schema:author N3a3a4fad10914273801a12bb67c33acb
14 schema:citation sg:pub.10.1023/a:1018988506336
15 https://doi.org/10.1002/jps.2600830337
16 https://doi.org/10.1002/jps.2600831211
17 https://doi.org/10.1002/polb.1994.090320312
18 https://doi.org/10.1016/0032-3861(93)90741-r
19 https://doi.org/10.1016/0260-8774(94)90028-0
20 https://doi.org/10.1016/0378-5173(94)90219-4
21 https://doi.org/10.1021/cr60135a002
22 https://doi.org/10.1021/j100619a008
23 https://doi.org/10.1021/ja01619a008
24 https://doi.org/10.1021/ma00047a030
25 https://doi.org/10.1039/tf9706600080
26 https://doi.org/10.1063/1.1744141
27 https://doi.org/10.1063/1.466117
28 https://doi.org/10.1088/0953-8984/6/28/006
29 https://doi.org/10.1098/rspa.1966.0138
30 https://doi.org/10.1248/cpb.37.2782
31 https://doi.org/10.1557/proc-215-11
32 https://doi.org/10.1557/proc-215-3
33 schema:datePublished 1995-06
34 schema:datePublishedReg 1995-06-01
35 schema:description PURPOSE: To measure the molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures (Tg), using indomethacin, poly (vinyl pyrrolidone) (PVP) and sucrose as model compounds. METHODS: Differential scanning calorimetry (DSC) was used to measure enthalpic relaxation of the amorphous samples after storage at temperatures 16-47 K below Tg for various time periods. The measured enthalpy changes were used to calculate molecular relaxation time parameters. Analogous changes in specimen dimensions were measured for PVP films using thermomechanical analysis. RESULTS: For all the model materials it was necessary to cool to at least 50 K below the experimental Tg before the molecular motions detected by DSC could be considered to be negligible over the lifetime of a typical pharmaceutical product. In each case the temperature dependence of the molecular motions below Tg was less than that typically reported above Tg and was rapidly changing. CONCLUSIONS: In the temperature range studied the model amorphous solids were in a transition zone between regions of very high molecular mobility above Tg and very low molecular mobility much further below Tg. In general glassy pharmaceutical solids should be expected to experience significant molecular mobility at temperatures up to fifty degrees below their glass transition temperature.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree false
39 schema:isPartOf N257d5087aeaf4de5a2198e96cfe1b2a1
40 N95becb7d08204d23bcf3e8127de85f7d
41 sg:journal.1094644
42 schema:name Molecular Mobility of Amorphous Pharmaceutical Solids Below Their Glass Transition Temperatures
43 schema:pagination 799-806
44 schema:productId N3902e110118d4eb7b650fb1c69ae180d
45 N57704b0e667a448698a5c10af634c6f1
46 Nac320d3eee9b4bcaa4dfe3e429a20f3b
47 Nb18c9c4a44f3481cbc14f7e57449ce4c
48 Nf2993332fe004269a4d53684942816de
49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052847671
50 https://doi.org/10.1023/a:1016292416526
51 schema:sdDatePublished 2019-04-10T21:36
52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
53 schema:sdPublisher N17eaf7d872ad4627973ed0d8554bbd12
54 schema:url http://link.springer.com/10.1023/A:1016292416526
55 sgo:license sg:explorer/license/
56 sgo:sdDataset articles
57 rdf:type schema:ScholarlyArticle
58 N17eaf7d872ad4627973ed0d8554bbd12 schema:name Springer Nature - SN SciGraph project
59 rdf:type schema:Organization
60 N257d5087aeaf4de5a2198e96cfe1b2a1 schema:volumeNumber 12
61 rdf:type schema:PublicationVolume
62 N2e3a767e37494b249558da70aeffebcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Indomethacin
64 rdf:type schema:DefinedTerm
65 N36892cf2cbd04e668ee81aa069c75475 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Chemistry, Pharmaceutical
67 rdf:type schema:DefinedTerm
68 N3902e110118d4eb7b650fb1c69ae180d schema:name pubmed_id
69 schema:value 7667182
70 rdf:type schema:PropertyValue
71 N3a3a4fad10914273801a12bb67c33acb rdf:first sg:person.0636134005.91
72 rdf:rest N5d95575736124c9788617c45b7328d59
73 N476fc0bc5ccb4c1382527a371516a92e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Sucrose
75 rdf:type schema:DefinedTerm
76 N53865a807c214dcebba20fe188aea497 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Models, Chemical
78 rdf:type schema:DefinedTerm
79 N57704b0e667a448698a5c10af634c6f1 schema:name dimensions_id
80 schema:value pub.1052847671
81 rdf:type schema:PropertyValue
82 N5d95575736124c9788617c45b7328d59 rdf:first sg:person.0674545256.27
83 rdf:rest N76d7dbfb61544e79b89ff5108cbd857c
84 N735a8a8d798744cc87b69ae9717db30a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Crystallization
86 rdf:type schema:DefinedTerm
87 N76d7dbfb61544e79b89ff5108cbd857c rdf:first sg:person.0100561403.96
88 rdf:rest rdf:nil
89 N84c735637a314036bed57149e3a5adbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Time Factors
91 rdf:type schema:DefinedTerm
92 N8758bc0608284eab830489fdf7179c14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Calorimetry
94 rdf:type schema:DefinedTerm
95 N95becb7d08204d23bcf3e8127de85f7d schema:issueNumber 6
96 rdf:type schema:PublicationIssue
97 Naa411c20595b440c875cd2f24743dfa3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Temperature
99 rdf:type schema:DefinedTerm
100 Nac320d3eee9b4bcaa4dfe3e429a20f3b schema:name readcube_id
101 schema:value fbba75dd7e98bb141cb564682209db17662f26e971586486b69426f6f3a23220
102 rdf:type schema:PropertyValue
103 Nb18c9c4a44f3481cbc14f7e57449ce4c schema:name doi
104 schema:value 10.1023/a:1016292416526
105 rdf:type schema:PropertyValue
106 Nb1d3364b7d264641905ad19f9e323052 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Molecular Structure
108 rdf:type schema:DefinedTerm
109 Ncd32cb5b78fc46d7973c6ae345f3003d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Glass
111 rdf:type schema:DefinedTerm
112 Nf2993332fe004269a4d53684942816de schema:name nlm_unique_id
113 schema:value 8406521
114 rdf:type schema:PropertyValue
115 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
116 schema:name Chemical Sciences
117 rdf:type schema:DefinedTerm
118 anzsrc-for:0307 schema:inDefinedTermSet anzsrc-for:
119 schema:name Theoretical and Computational Chemistry
120 rdf:type schema:DefinedTerm
121 sg:journal.1094644 schema:issn 0724-8741
122 1573-904X
123 schema:name Pharmaceutical Research
124 rdf:type schema:Periodical
125 sg:person.0100561403.96 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
126 schema:familyName Zografi
127 schema:givenName George
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0100561403.96
129 rdf:type schema:Person
130 sg:person.0636134005.91 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
131 schema:familyName Hancock
132 schema:givenName Bruno C.
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636134005.91
134 rdf:type schema:Person
135 sg:person.0674545256.27 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
136 schema:familyName Shamblin
137 schema:givenName Sheri L.
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674545256.27
139 rdf:type schema:Person
140 sg:pub.10.1023/a:1018988506336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010235358
141 https://doi.org/10.1023/a:1018988506336
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1002/jps.2600830337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013943728
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1002/jps.2600831211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031087388
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1002/polb.1994.090320312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004213909
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1016/0032-3861(93)90741-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1040895300
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1016/0260-8774(94)90028-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006875439
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1016/0378-5173(94)90219-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018372208
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1021/cr60135a002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053927957
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1021/j100619a008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055674247
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1021/ja01619a008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055813183
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1021/ma00047a030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056174630
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1039/tf9706600080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000572480
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1063/1.1744141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057806582
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1063/1.466117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058044123
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1088/0953-8984/6/28/006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020108276
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1098/rspa.1966.0138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044798096
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1248/cpb.37.2782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037646836
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1557/proc-215-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067917921
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1557/proc-215-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067917939
178 rdf:type schema:CreativeWork
179 https://www.grid.ac/institutes/grid.14003.36 schema:alternateName University of Wisconsin–Madison
180 schema:name School of Pharmacy, University of Wisconsin-Madison, 53706, Madison, Wisconsin
181 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...