Evaluation of Retinoid Lactones as Topical Therapeutic Agents in Dermatology View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-07

AUTHORS

Anita H. Lewin, Sherry L. Black, Mary E. Bos, R. Richard Goehring, Xina Nair, Gary Whiting, Pamela Bouquin, Geraldine Tetrault, F. Ivy Carroll

ABSTRACT

PURPOSE: Optimization of the therapeutic ratio of analogs of the topically active 11-cis, 13-cis-12-hydroxymethylretinoic acid, delta-lactone (1) relative to antihyperproliferation and antihyperkeratinization vs. toxicity. METHODS: Nine analogs of 1, in which variations were made in the lipophilic cyclohexenyl moiety or in the lactone ring, were evaluated for topical activity against hyperkeratinization, inhibition of TPA-induced DNA synthesis and for skin irritation. RESULTS: Although more potent lactones than the parent lactone 1 were identified, none possessed the favorable therapeutic ratio associated with 1. CONCLUSIONS: The delta-lactone 1 possesses unique molecular features responsible for its desirable therapeutic ratio as an antihyperproliferative and antihyperkeratotic agent. In view of its very low systemic retinoid toxicity and the absence of any systemic toxicity, this lactone may be a good candidate for use in the topical treatment of acne. More... »

PAGES

983-992

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1016250129246

DOI

http://dx.doi.org/10.1023/a:1016250129246

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052617200

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7494818


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