Association of vitamin D receptor gene polymorphism with sporadic breast cancer in Taiwanese patients* View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-07

AUTHORS

Ming-Feng Hou, Yin-Chun Tien, Gau-Tyan Lin, Chung-Jen Chen, Chih-San Liu, Sen-Yuen Lin, Tsung-Jen Huang

ABSTRACT

Purpose. Previous reports have suggested that polymorphism in the vitamin D receptor (VDR) gene is associated with sporadic breast cancer, but there is controversy among different authors and ethnic groups. The purpose of this study was to determine whether polymorphism in the VDR gene might also influence breast cancer risk in Taiwan, a country with a low incidence of breast cancer.Methods. Polymorphisms in the end of the VDR gene were genotyped for 34 Taiwanese women with sporadic breast cancer, 46 with benign breast tumors and 169 cancer-free female cohort controls.Results. The ApaI, TaqI, and BsmI polymorphisms in the 3′ end of the VDR gene were associated with breast cancer risk, with a trend for increasing risk with increased numbers of BsmI \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $$\underline {\text{B}} $$ \end{document} alleles and ApaI \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $$\underline {{\text{AA}}} $$ \end{document} genotypes. When the allele frequencies of BsmI polymorphism were compared among the three populations, a significant difference was observed (χ2 = 13.684, df = 4, p = 0.0084). The OR of the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $$\underline {{\text{Aa}}} $$ \end{document} genotype was 0.333 (95% CI = 0.114–0.978) and that of the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $$\underline {{\text{aa}}} $$ \end{document} genotype was 0.515 (95% C1 = 0.190–1.398). These data indicate that the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $$\underline {{\text{AA}}} $$ \end{document} genotype may be associated with an increased risk of breast cancer, while the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $$\underline {{\text{Aa}}}$$ \end{document} genotype tends to be associated with decreased risk. The TaqI polymorphism was not associated with breast cancer risk in this study.Conclusion. These results suggest that polymorphic variation in or near the 3′ end of the VDR gene may influence breast cancer risk in Taiwanese women and justifies further investigation of the role of VDR for sporadic breast cancer in low-incidence areas. These findings also should help when designing targeted therapy. More... »

PAGES

1-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1016048900049

DOI

http://dx.doi.org/10.1023/a:1016048900049

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033669925

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12150447


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26 schema:description Purpose. Previous reports have suggested that polymorphism in the vitamin D receptor (VDR) gene is associated with sporadic breast cancer, but there is controversy among different authors and ethnic groups. The purpose of this study was to determine whether polymorphism in the VDR gene might also influence breast cancer risk in Taiwan, a country with a low incidence of breast cancer.Methods. Polymorphisms in the end of the VDR gene were genotyped for 34 Taiwanese women with sporadic breast cancer, 46 with benign breast tumors and 169 cancer-free female cohort controls.Results. The ApaI, TaqI, and BsmI polymorphisms in the 3′ end of the VDR gene were associated with breast cancer risk, with a trend for increasing risk with increased numbers of BsmI \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $$\underline {\text{B}} $$ \end{document} alleles and ApaI \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $$\underline {{\text{AA}}} $$ \end{document} genotypes. When the allele frequencies of BsmI polymorphism were compared among the three populations, a significant difference was observed (χ2 = 13.684, df = 4, p = 0.0084). The OR of the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $$\underline {{\text{Aa}}} $$ \end{document} genotype was 0.333 (95% CI = 0.114–0.978) and that of the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $$\underline {{\text{aa}}} $$ \end{document} genotype was 0.515 (95% C1 = 0.190–1.398). These data indicate that the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $$\underline {{\text{AA}}} $$ \end{document} genotype may be associated with an increased risk of breast cancer, while the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $$\underline {{\text{Aa}}}$$ \end{document} genotype tends to be associated with decreased risk. The TaqI polymorphism was not associated with breast cancer risk in this study.Conclusion. These results suggest that polymorphic variation in or near the 3′ end of the VDR gene may influence breast cancer risk in Taiwanese women and justifies further investigation of the role of VDR for sporadic breast cancer in low-incidence areas. These findings also should help when designing targeted therapy.
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32 schema:keywords ApaI
33 BsmI
34 BsmI polymorphism
35 D receptor gene polymorphisms
36 Taiwan
37 Taiwanese patients
38 Taiwanese women
39 TaqI
40 TaqI polymorphism
41 VDR
42 VDR gene
43 allele frequencies
44 alleles
45 area
46 association
47 authors
48 benign breast tumors
49 breast cancer
50 breast cancer risk
51 breast tumors
52 cancer
53 cancer risk
54 cohort controls
55 control
56 controversy
57 countries
58 data
59 differences
60 different authors
61 end
62 ethnic groups
63 findings
64 frequency
65 further investigation
66 gene polymorphisms
67 genes
68 genotypes
69 group
70 incidence
71 investigation
72 low-incidence areas
73 lower incidence
74 number
75 patients
76 polymorphic variation
77 polymorphism
78 population
79 previous reports
80 purpose
81 receptor gene
82 receptor gene polymorphisms
83 report
84 results
85 risk
86 role
87 role of VDR
88 significant differences
89 sporadic breast cancer
90 study
91 therapy
92 trends
93 tumors
94 variation
95 vitamin D receptor gene
96 vitamin D receptor gene polymorphisms
97 women
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