Enhancement of Colonic Drug Absorption by the Transcellular Permeation Route View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-12

AUTHORS

Mikio Tomita, Masahiro Hayashi, Toshiharu Horie, Takayuki Ishizawa, Shoji Awazu

ABSTRACT

The effects of sodium caprate and sodium caprylate on transcellular permeation routes were examined in rats. The release of membrane phospholipids was significantly increased only by caprate, while protein release did not change from the control in the presence of caprate or caprylate, indicating that the extent of membrane disruption was insufficient to account for enhanced permeation. Using brush border membrane (BBM) vesicles prepared from colon, with their protein and lipid component labeled by fluorescent probes, the perturbing actions of caprate and caprylate toward the membrane were examined by fluorescence polarization. Caprate interacted with membrane protein and lipids, and caprylate mainly with protein, causing perturbation to the membrane. The release of 5(6)-carboxyfluorescein previously included in BBM vesicles was increased by caprate but not by caprylate. These results suggest that caprate enhances permeability via the transcellular route through membrane perturbation. More... »

PAGES

786-789

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1015992819290

DOI

http://dx.doi.org/10.1023/a:1015992819290

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025141020

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3247289


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