Characterization of a Hot-Melt Fluid Bed Coating Process for Fine Granules View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-11

AUTHORS

Michael J. Jozwiakowski, David M. Jones, Robert M. Franz

ABSTRACT

The equipment modifications and process changes necessary to perform hot-melt particle coating in a fluid bed granulator are reviewed. A specific case is presented in which partially hydrogenated cottonseed oil is coated onto fine granules (mean particle size, 77 µm; range, 10–150 µm; one standard deviation is 10 µm) composed of a hydrophobic drug and sucrose. The major variables were product bed temperature, temperature of the wax, spray rate, and atomization air pressure. The product bed temperature was selected to give the optimum congealing rate, and the latter three variables were varied in a statistically designed experiment. The physical properties of wax-coated granules fabricated using combinations of process variables were examined. Response surface analysis was used to determine the optimum process settings in terms of dissolution, particle size, and density of the coated product. This system proved quite adequate for the production of uniformly coated granules, with the best product being obtained at the optimized conditions using 120°C atomization air and molten coating temperature, 30 g/min as the spray rate, and an atomization air pressure of 5 bar. More... »

PAGES

1119-1126

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1015972007342

DOI

http://dx.doi.org/10.1023/a:1015972007342

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013490742

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2293209


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