A Statistical Approach for the Development of an Oral Controlled-Release Matrix Tablet View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-10

AUTHORS

Alton D. Johnson, Virgil L. Anderson, Garnet E. Peck

ABSTRACT

Tablet matrix compositions for optimized prolonged release were selected by surface response methodology. The extreme vertices experimental design was used to develop a surface response model which mathematically defined the release of active component from the tablet matrix as controlled by the percentage of the excipient components. The model, a statistical quadratic equation with a standard error of 3.3, was validated for accurate prediction of drug release profiles and used to identify optimum formulations. This study demonstrated a new application of the extreme vertices experimental design, an efficient method for evaluating a complex mixture system for controlled release, where specific constraints are placed on one or more of the components. More... »

PAGES

1092-1097

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1015911721455

DOI

http://dx.doi.org/10.1023/a:1015911721455

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031324395

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2281042


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