Effect of Cyclodextrin Derivatives on Indomethacin Stability in Aqueous Solution View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-05

AUTHORS

Thomas Backensfeld, Bernd W. Müller, Michael Wiese, Joachim K. Seydel

ABSTRACT

The effect of various cyclodextrins (CD) and cyclodextrin derivatives on indomethacin stability in phosphate buffer, pH 7.4, was investigated. The influence of CD-ring size, type of substituent, degree of substitution, substitution pattern, and influence of CD concentration were monitored. The indomethacin complex in solution was studied by 1H-NMR spectroscopy to develop a molecular inclusion model. The most favorable ring size for the stabilization of indomethacin was the beta-CD. The beta-CD derivatives inhibited the hydrolysis of indomethacin more effectively than the parent CD. Among the studied CD derivatives, those with lipophilic substituents, such as ethyl or methyl, were superior to those with hydrophilic substitutents. The more hydroxyl groups of the glucose moiety are substituted, the better is the stabilizing effect. Further, the p-chlorobenzoic part of the indomethacin molecule is included in the CD channel. More... »

PAGES

484-490

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1015860531565

DOI

http://dx.doi.org/10.1023/a:1015860531565

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012490579

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2367316


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0306", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Physical Chemistry (incl. Structural)", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "2-Hydroxypropyl-beta-cyclodextrin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Computer Simulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclodextrins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dextrins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Interactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Stability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Indomethacin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Spectroscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Solutions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Starch", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Structure-Activity Relationship", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Temperature", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Water", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "beta-Cyclodextrins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kiel University", 
          "id": "https://www.grid.ac/institutes/grid.9764.c", 
          "name": [
            "Department of Pharmaceutics, Christian Albrechts University, Gutenbergstr. 76-78, D-2300, Kiel, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Backensfeld", 
        "givenName": "Thomas", 
        "id": "sg:person.011713414154.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011713414154.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kiel University", 
          "id": "https://www.grid.ac/institutes/grid.9764.c", 
          "name": [
            "Department of Pharmaceutics, Christian Albrechts University, Gutenbergstr. 76-78, D-2300, Kiel, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00fcller", 
        "givenName": "Bernd W.", 
        "id": "sg:person.0633716005.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633716005.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute for Experimental Biology and Medicine, D-2061, Borstel, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wiese", 
        "givenName": "Michael", 
        "id": "sg:person.01101066243.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101066243.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute for Experimental Biology and Medicine, D-2061, Borstel, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seydel", 
        "givenName": "Joachim K.", 
        "id": "sg:person.013006234344.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013006234344.47"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/jps.2600660913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007246084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1016301919928", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020678297", 
          "https://doi.org/10.1023/a:1016301919928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5173(85)90201-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021498073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5173(85)90201-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021498073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.198003441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026333991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0008-6215(00)88048-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034252731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1015907927950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036738023", 
          "https://doi.org/10.1023/a:1015907927950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1246/bcsj.43.1909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038626214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.23.1205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041473776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079769185", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080143723", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1990-05", 
    "datePublishedReg": "1990-05-01", 
    "description": "The effect of various cyclodextrins (CD) and cyclodextrin derivatives on indomethacin stability in phosphate buffer, pH 7.4, was investigated. The influence of CD-ring size, type of substituent, degree of substitution, substitution pattern, and influence of CD concentration were monitored. The indomethacin complex in solution was studied by 1H-NMR spectroscopy to develop a molecular inclusion model. The most favorable ring size for the stabilization of indomethacin was the beta-CD. The beta-CD derivatives inhibited the hydrolysis of indomethacin more effectively than the parent CD. Among the studied CD derivatives, those with lipophilic substituents, such as ethyl or methyl, were superior to those with hydrophilic substitutents. The more hydroxyl groups of the glucose moiety are substituted, the better is the stabilizing effect. Further, the p-chlorobenzoic part of the indomethacin molecule is included in the CD channel.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1023/a:1015860531565", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094644", 
        "issn": [
          "0724-8741", 
          "1573-904X"
        ], 
        "name": "Pharmaceutical Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Effect of Cyclodextrin Derivatives on Indomethacin Stability in Aqueous Solution", 
    "pagination": "484-490", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3b81d0069683eab90cce331d72cab67bd5f0737c18eb985eab1fb6adc97547ad"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2367316"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8406521"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1015860531565"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012490579"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1015860531565", 
      "https://app.dimensions.ai/details/publication/pub.1012490579"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000504.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1023/A:1015860531565"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1015860531565'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1015860531565'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1015860531565'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1015860531565'


 

This table displays all metadata directly associated to this object as RDF triples.

188 TRIPLES      21 PREDICATES      55 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1015860531565 schema:about N0104490eacf04ba0ab0b3335c1aa1882
2 N0ea89219ddb24f159efc694f858fc9a1
3 N21072ea732f84c438a204fe18d354c50
4 N286432eb8c5a42d599cbfd6e9ba07e33
5 N4279ff827a3f49c690ef31504be1ac08
6 N447b707c804f41e298ee6a1fb5d6136a
7 N4a705918fb4b4f54a97009f0e165d7b3
8 N4c45abf152224d419365c7e1bf36f2d4
9 N63821902fd1a4637a955c1a67cd7c158
10 N7e53742814304ab09c96861a19aef503
11 N7edc4cb27714486a9d494a88acd7c1a6
12 N8629e067e7a14dca91aa45fd8a9831dd
13 N93e95f6ad18b4e7eb3468a9ecc43cf34
14 Nbc497b65eb3240848c9a1429f3b59c0a
15 Nd6942067d2fc4eeb99f146d5dd2b4497
16 Ne9cc7f90b2ef44ca9f94116e39e68dc9
17 anzsrc-for:03
18 anzsrc-for:0306
19 schema:author Nd20ade5936cf4b5e89e261a146a9b68e
20 schema:citation sg:pub.10.1023/a:1015907927950
21 sg:pub.10.1023/a:1016301919928
22 https://app.dimensions.ai/details/publication/pub.1079769185
23 https://app.dimensions.ai/details/publication/pub.1080143723
24 https://doi.org/10.1002/anie.198003441
25 https://doi.org/10.1002/jps.2600660913
26 https://doi.org/10.1016/0378-5173(85)90201-7
27 https://doi.org/10.1016/s0008-6215(00)88048-9
28 https://doi.org/10.1246/bcsj.43.1909
29 https://doi.org/10.1248/cpb.23.1205
30 schema:datePublished 1990-05
31 schema:datePublishedReg 1990-05-01
32 schema:description The effect of various cyclodextrins (CD) and cyclodextrin derivatives on indomethacin stability in phosphate buffer, pH 7.4, was investigated. The influence of CD-ring size, type of substituent, degree of substitution, substitution pattern, and influence of CD concentration were monitored. The indomethacin complex in solution was studied by 1H-NMR spectroscopy to develop a molecular inclusion model. The most favorable ring size for the stabilization of indomethacin was the beta-CD. The beta-CD derivatives inhibited the hydrolysis of indomethacin more effectively than the parent CD. Among the studied CD derivatives, those with lipophilic substituents, such as ethyl or methyl, were superior to those with hydrophilic substitutents. The more hydroxyl groups of the glucose moiety are substituted, the better is the stabilizing effect. Further, the p-chlorobenzoic part of the indomethacin molecule is included in the CD channel.
33 schema:genre research_article
34 schema:inLanguage en
35 schema:isAccessibleForFree false
36 schema:isPartOf N90ae6b6c3f43415aa2f5d69082cafd5e
37 Na4a4045607c14d8aa1f684a0bac1b9ce
38 sg:journal.1094644
39 schema:name Effect of Cyclodextrin Derivatives on Indomethacin Stability in Aqueous Solution
40 schema:pagination 484-490
41 schema:productId N1375fc9050ea4e4f92d0c82666d82ac9
42 N4fb68d8a82464313bd8cce1dbdd5c204
43 N5c581454dcc34e9298567278f71cb22a
44 N6fd3b7581be84623ad38782d7b02d8f5
45 N8602fe02b0824523924c0df5bf2a4547
46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012490579
47 https://doi.org/10.1023/a:1015860531565
48 schema:sdDatePublished 2019-04-11T01:05
49 schema:sdLicense https://scigraph.springernature.com/explorer/license/
50 schema:sdPublisher N9d0b223b7867444999516d9ef33ff08c
51 schema:url http://link.springer.com/10.1023/A:1015860531565
52 sgo:license sg:explorer/license/
53 sgo:sdDataset articles
54 rdf:type schema:ScholarlyArticle
55 N0104490eacf04ba0ab0b3335c1aa1882 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
56 schema:name Drug Interactions
57 rdf:type schema:DefinedTerm
58 N0ea89219ddb24f159efc694f858fc9a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
59 schema:name 2-Hydroxypropyl-beta-cyclodextrin
60 rdf:type schema:DefinedTerm
61 N1375fc9050ea4e4f92d0c82666d82ac9 schema:name dimensions_id
62 schema:value pub.1012490579
63 rdf:type schema:PropertyValue
64 N21072ea732f84c438a204fe18d354c50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Water
66 rdf:type schema:DefinedTerm
67 N286432eb8c5a42d599cbfd6e9ba07e33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Dose-Response Relationship, Drug
69 rdf:type schema:DefinedTerm
70 N3c3b7f744af84e569aed5e7b8e7afdaa rdf:first sg:person.01101066243.50
71 rdf:rest Nf77979d6bc5f4a6a8857ce74c42a3d40
72 N4279ff827a3f49c690ef31504be1ac08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Magnetic Resonance Spectroscopy
74 rdf:type schema:DefinedTerm
75 N447b707c804f41e298ee6a1fb5d6136a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Cyclodextrins
77 rdf:type schema:DefinedTerm
78 N4a705918fb4b4f54a97009f0e165d7b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Models, Molecular
80 rdf:type schema:DefinedTerm
81 N4c45abf152224d419365c7e1bf36f2d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Temperature
83 rdf:type schema:DefinedTerm
84 N4fb68d8a82464313bd8cce1dbdd5c204 schema:name nlm_unique_id
85 schema:value 8406521
86 rdf:type schema:PropertyValue
87 N5c581454dcc34e9298567278f71cb22a schema:name readcube_id
88 schema:value 3b81d0069683eab90cce331d72cab67bd5f0737c18eb985eab1fb6adc97547ad
89 rdf:type schema:PropertyValue
90 N63821902fd1a4637a955c1a67cd7c158 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Indomethacin
92 rdf:type schema:DefinedTerm
93 N6fd3b7581be84623ad38782d7b02d8f5 schema:name doi
94 schema:value 10.1023/a:1015860531565
95 rdf:type schema:PropertyValue
96 N7e53742814304ab09c96861a19aef503 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Starch
98 rdf:type schema:DefinedTerm
99 N7edc4cb27714486a9d494a88acd7c1a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Solutions
101 rdf:type schema:DefinedTerm
102 N8602fe02b0824523924c0df5bf2a4547 schema:name pubmed_id
103 schema:value 2367316
104 rdf:type schema:PropertyValue
105 N8629e067e7a14dca91aa45fd8a9831dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Drug Stability
107 rdf:type schema:DefinedTerm
108 N90ae6b6c3f43415aa2f5d69082cafd5e schema:volumeNumber 7
109 rdf:type schema:PublicationVolume
110 N93e95f6ad18b4e7eb3468a9ecc43cf34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Computer Simulation
112 rdf:type schema:DefinedTerm
113 N9d0b223b7867444999516d9ef33ff08c schema:name Springer Nature - SN SciGraph project
114 rdf:type schema:Organization
115 Na4a4045607c14d8aa1f684a0bac1b9ce schema:issueNumber 5
116 rdf:type schema:PublicationIssue
117 Nb37bf947587246a28d5b4704f539a602 schema:name Institute for Experimental Biology and Medicine, D-2061, Borstel, FRG
118 rdf:type schema:Organization
119 Nbc497b65eb3240848c9a1429f3b59c0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name beta-Cyclodextrins
121 rdf:type schema:DefinedTerm
122 Nd20ade5936cf4b5e89e261a146a9b68e rdf:first sg:person.011713414154.29
123 rdf:rest Nf2d540b7c8084336b8a89651b0127ec4
124 Nd6942067d2fc4eeb99f146d5dd2b4497 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Dextrins
126 rdf:type schema:DefinedTerm
127 Ne9cc7f90b2ef44ca9f94116e39e68dc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Structure-Activity Relationship
129 rdf:type schema:DefinedTerm
130 Nf2d540b7c8084336b8a89651b0127ec4 rdf:first sg:person.0633716005.17
131 rdf:rest N3c3b7f744af84e569aed5e7b8e7afdaa
132 Nf77979d6bc5f4a6a8857ce74c42a3d40 rdf:first sg:person.013006234344.47
133 rdf:rest rdf:nil
134 Nf824cfe3c79647008d5a65da74be061f schema:name Institute for Experimental Biology and Medicine, D-2061, Borstel, FRG
135 rdf:type schema:Organization
136 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
137 schema:name Chemical Sciences
138 rdf:type schema:DefinedTerm
139 anzsrc-for:0306 schema:inDefinedTermSet anzsrc-for:
140 schema:name Physical Chemistry (incl. Structural)
141 rdf:type schema:DefinedTerm
142 sg:journal.1094644 schema:issn 0724-8741
143 1573-904X
144 schema:name Pharmaceutical Research
145 rdf:type schema:Periodical
146 sg:person.01101066243.50 schema:affiliation Nf824cfe3c79647008d5a65da74be061f
147 schema:familyName Wiese
148 schema:givenName Michael
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101066243.50
150 rdf:type schema:Person
151 sg:person.011713414154.29 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
152 schema:familyName Backensfeld
153 schema:givenName Thomas
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011713414154.29
155 rdf:type schema:Person
156 sg:person.013006234344.47 schema:affiliation Nb37bf947587246a28d5b4704f539a602
157 schema:familyName Seydel
158 schema:givenName Joachim K.
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013006234344.47
160 rdf:type schema:Person
161 sg:person.0633716005.17 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
162 schema:familyName Müller
163 schema:givenName Bernd W.
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633716005.17
165 rdf:type schema:Person
166 sg:pub.10.1023/a:1015907927950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036738023
167 https://doi.org/10.1023/a:1015907927950
168 rdf:type schema:CreativeWork
169 sg:pub.10.1023/a:1016301919928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020678297
170 https://doi.org/10.1023/a:1016301919928
171 rdf:type schema:CreativeWork
172 https://app.dimensions.ai/details/publication/pub.1079769185 schema:CreativeWork
173 https://app.dimensions.ai/details/publication/pub.1080143723 schema:CreativeWork
174 https://doi.org/10.1002/anie.198003441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026333991
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1002/jps.2600660913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007246084
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/0378-5173(85)90201-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021498073
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/s0008-6215(00)88048-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034252731
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1246/bcsj.43.1909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038626214
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1248/cpb.23.1205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041473776
185 rdf:type schema:CreativeWork
186 https://www.grid.ac/institutes/grid.9764.c schema:alternateName Kiel University
187 schema:name Department of Pharmaceutics, Christian Albrechts University, Gutenbergstr. 76-78, D-2300, Kiel, FRG
188 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...