Pathophysiologic and Therapeutic Importance of Tissue ACE: A Consensus Report View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-03

AUTHORS

Victor J. Dzau, Kenneth Bernstein, David Celermajer, Jerome Cohen, Björn Dahlöf, John Deanfield, Javier Diez, Helmut Drexler, Roberto Ferrari, Wiek van Gilst, Lennart Hansson, Burkhard Hornig, Ahsan Husain, Colin Johnston, Harold Lazar, Eva Lonn, Thomas Lüscher, John Mancini, Albert Mimran, Carl Pepine, Ton Rabelink, Willem Remme, Luis Ruilope, Marcel Ruzicka, Heribert Schunkert, Karl Swedberg, Thomas Unger, Douglas Vaughan, Michael Weber

ABSTRACT

Angiotensin-converting enzyme (ACE) activation and the de novo production of angiotensin II contribute to cardiovascular disease through direct pathological tissue effects, including vascular remodeling and inflammation, as well as indirect action on nitric oxide bioavailability and its consequences. The endothelium plays a pivotal role in both vascular function and structure; thus, the predominant localization of ACE to the endothelium has implications for the pathobiology of vascular disease, such as coronary artery disease. Numerous experimental studies and clinical trials support the emerging realization that tissue ACE is a vital therapeutic target, and that its inhibition may restore endothelial function or prevent endothelial dysfunction. These effects exceed those attributable to blood pressure reduction alone; hence, ACE inhibitors may exert an important part of their effects through direct tissue action. Pharmacologic studies show that while ACE inhibitors may differ according to their binding affinity for tissue ACE the clinical significance remains to be determined. More... »

PAGES

149-160

Journal

TITLE

Cardiovascular Drugs and Therapy

ISSUE

2

VOLUME

16

Author Affiliations

  • Department of Medicine, Brigham Women's Hospital, Boston, MA, USA
  • Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
  • Department of Medicine, University of Sydney, c/o Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia
  • Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO, USA
  • Department of Medicine, Sahlgrenska University Hospital/Ostra, Nilssonsberg, Sweden
  • Vascular Physiology Unit, Great Ormond Street Hospital for Children, London, United Kingdom
  • Unidad de Fisiopatologia Vascular, Edificio de Ciencias, Universidad de Navarra, Calle Iruniarrea, Pampalona, Spain
  • Department of Cardiology, Medizinische Hochschule Hannover, Hannover, Germany
  • Department of Clinical and Experimental Medicine, Nuove Cliniche, Corso Ferrara, Italy
  • Department of Clinical Pharmacology, University Hospital Groningen, Groningen, The Netherlands
  • Clinical Hypertension Research, University of Uppsala, Uppsala, Sweden
  • Victor Chang Cardiac Research Institute, Darlinghurst, Sydney, Australia
  • Baker Institute, Melbourne, Australia
  • Department of Cardiothoracic Surgery, Boston Medical Center, Boston, MA, USA
  • Division of Cardiology, HGH-McMaster Clinic, Hamilton, Ontario, Canada
  • Division of Cardiology, University Hospital Zurich, Zurich, Switzerland
  • Department of Medicine, Vancouver General Hospital, Vancouver, BC, Canada
  • Medecine Interne et Hypertension Arterielle, Centre Hospitalier, Universitaire, Hospital Lapeyronie, Montpellier, France
  • Division of Cardiovascular Medicine, University of Florida Gainesville, Gainesville, FL, USA
  • Department of Internal Medicine, University Hospital Utrecht, Utrecht, The Netherlands
  • Sticares Cardiovascular Research FnD, Rhoon, The Netherlands
  • Unidad de Hypertension, Hospital Madrid, Spain
  • University of Ottawa Heart Institute, Ottawa, Ontario, Canada
  • Klinik und Poliklinik fur Innere Medizin II, Franz-Josef-Strauss-Allee, Regensburg, Germany
  • Sahlgrenska University Hospital/Ostra, Göteberg, Sweden
  • Christian-Albrechts-University Kiel, Kiel, Germany
  • Division of Cardiology, Vanderbilt University School of Medicine, Nashville, TN, USA
  • Department of Medicine, Brookdale Hospital, Brooklyn, NY, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1023/a:1015709617405

    DOI

    http://dx.doi.org/10.1023/a:1015709617405

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004102597

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12090908


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