Ontology type: schema:ScholarlyArticle
2002-05
AUTHORSMartin E. Gleave, Toby Zellweger, Kim Chi, Hideaki Miyake, Satoshi Kiyama, Laura July, Simon Leung
ABSTRACTThe main obstacle to improved survival of advanced prostate cancer is our failure to prevent its progression to its lethal and untreatable stage of androgen independence. New therapeutic strategies designed to prevent androgen-independent (AI) progression must be developed before significant impact on survival can be achieved. Characterization of changes in gene expression profiles after androgen ablation and during progression to androgen-independence suggest that the various therapies used to kill neoplastic cells may precipitate changes in gene expression that lead to the resistant phenotype. Castration-induced increases in antiapoptosis genes, Bcl-2 and clusterin, help create a resistant phenotype, while antisense oligonucleotides can inhibit these adaptive cell survival mechanisms and enhance both hormone and chemotherapy. Ongoing efforts are necessary to identify additional molecular pathways mediating AI progression and chemoresistance, since complexities of tumor heterogeneity and adaptability dictate that optimal control over tumor progression will require multi-target systemic therapies. More... »
PAGES145-158
http://scigraph.springernature.com/pub.10.1023/a:1015694802521
DOIhttp://dx.doi.org/10.1023/a:1015694802521
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1011716096
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/12099575
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JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1015694802521'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1015694802521'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1015694802521'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1015694802521'
This table displays all metadata directly associated to this object as RDF triples.
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