Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in Northern and Southern Sweden View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-05

AUTHORS

Rudolf Kaaks, Eva Lundin, Jonas Manjer, Sabina Rinaldi, Carine Biessy, Stefan Söderberg, Per Lenner, Lars Janzon, Elio Riboli, Göran Berglund, Göran Hallmans

ABSTRACT

Objective: To examine the possible relationships of breast cancer risk to prediagnostic plasma levels of insulin; insulin-like growth factor-I (IGF-I); and IGF-binding proteins -1, -2, and -3. Methods: Within two prospective cohorts in Umeå and Malmö we measured plasma concentrations of insulin, IGF-I, and IGFBPs for a total of 513 incident breast cancer cases and 987 matched controls. Results: Globally, risk was unassociated with levels of IGF-I, IGFBP-3, or IGF-I adjusted for IGFBP-3. When breaking down the analysis by subgroups of age at blood donation, an increase in risk was observed for increasing levels of IGF-I in women aged 55 or older, in the Umeå cohort only (odds ratios of 1.00, 1.73, 1.76, 1.90; ptrend = 0.05). This effect weakened, however, when the analysis was restricted to subjects who did not use exogenous hormones for the treatment of menopausal symptoms. Levels of IGF-I and IGFBP-3 were not related to risk in younger women, recruited before age 50, contrary to observations from previous studies. In a subcohort where blood samples had been collected after at least four hours of fasting, breast cancer risk showed no clear associations with levels of insulin, IGFBP-1, or IGFBP-2. Conclusions: Our results do not confirm earlier findings of an association of plasma IGF-I levels with breast cancer risk especially in young women, but suggest a possible association with postmenopausal breast cancer risk, possibly among ERT/HRT users only. Our results do not support the hypothesis that elevated plasma insulin levels, and reduced levels of IGFBP-1 and IGFBP-2, are associated with increased breast cancer risk. More... »

PAGES

307-316

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1015270324325

DOI

http://dx.doi.org/10.1023/a:1015270324325

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021221270

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12074500


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hormone Replacement Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin-Like Growth Factor Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin-Like Growth Factor I", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sweden", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Unit of Nutrition and Cancer, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France", 
          "id": "http://www.grid.ac/institutes/grid.17703.32", 
          "name": [
            "Unit of Nutrition and Cancer, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaaks", 
        "givenName": "Rudolf", 
        "id": "sg:person.015420102437.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015420102437.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ume\u00e5, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.12650.30", 
          "name": [
            "University of Ume\u00e5, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lundin", 
        "givenName": "Eva", 
        "id": "sg:person.01056300321.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056300321.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lund University, UMAS, 205 02, Malm\u00f6, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.4514.4", 
          "name": [
            "Lund University, UMAS, 205 02, Malm\u00f6, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manjer", 
        "givenName": "Jonas", 
        "id": "sg:person.01001561122.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001561122.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit of Nutrition and Cancer, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France", 
          "id": "http://www.grid.ac/institutes/grid.17703.32", 
          "name": [
            "Unit of Nutrition and Cancer, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rinaldi", 
        "givenName": "Sabina", 
        "id": "sg:person.01305543702.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305543702.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit of Nutrition and Cancer, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France", 
          "id": "http://www.grid.ac/institutes/grid.17703.32", 
          "name": [
            "Unit of Nutrition and Cancer, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Biessy", 
        "givenName": "Carine", 
        "id": "sg:person.01345317212.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345317212.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ume\u00e5, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.12650.30", 
          "name": [
            "University of Ume\u00e5, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "S\u00f6derberg", 
        "givenName": "Stefan", 
        "id": "sg:person.016465323374.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016465323374.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ume\u00e5, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.12650.30", 
          "name": [
            "University of Ume\u00e5, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lenner", 
        "givenName": "Per", 
        "id": "sg:person.0721051037.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721051037.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lund University, UMAS, 205 02, Malm\u00f6, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.4514.4", 
          "name": [
            "Lund University, UMAS, 205 02, Malm\u00f6, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Janzon", 
        "givenName": "Lars", 
        "id": "sg:person.01051311312.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051311312.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit of Nutrition and Cancer, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France", 
          "id": "http://www.grid.ac/institutes/grid.17703.32", 
          "name": [
            "Unit of Nutrition and Cancer, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riboli", 
        "givenName": "Elio", 
        "id": "sg:person.01253670741.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253670741.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lund University, UMAS, 205 02, Malm\u00f6, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.4514.4", 
          "name": [
            "Lund University, UMAS, 205 02, Malm\u00f6, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berglund", 
        "givenName": "G\u00f6ran", 
        "id": "sg:person.01313726246.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313726246.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ume\u00e5, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.12650.30", 
          "name": [
            "University of Ume\u00e5, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hallmans", 
        "givenName": "G\u00f6ran", 
        "id": "sg:person.01023564410.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023564410.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1023/a:1018789527533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002705289", 
          "https://doi.org/10.1023/a:1018789527533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1097-1141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016201589", 
          "https://doi.org/10.1038/nm1097-1141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1005831013718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049782404", 
          "https://doi.org/10.1023/a:1005831013718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00051703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010664099", 
          "https://doi.org/10.1007/bf00051703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1008903727238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022593002", 
          "https://doi.org/10.1023/a:1008903727238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.2001.1899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028451934", 
          "https://doi.org/10.1054/bjoc.2001.1899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051002438", 
          "https://doi.org/10.1038/sj.onc.1203349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1009559014703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039331289", 
          "https://doi.org/10.1023/a:1009559014703"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-05", 
    "datePublishedReg": "2002-05-01", 
    "description": "Objective: To examine the possible relationships of breast cancer risk to prediagnostic plasma levels of insulin; insulin-like growth factor-I (IGF-I); and IGF-binding proteins -1, -2, and -3. Methods: Within two prospective cohorts in Ume\u00e5 and Malm\u00f6 we measured plasma concentrations of insulin, IGF-I, and IGFBPs for a total of 513 incident breast cancer cases and 987 matched controls. Results: Globally, risk was unassociated with levels of IGF-I, IGFBP-3, or IGF-I adjusted for IGFBP-3. When breaking down the analysis by subgroups of age at blood donation, an increase in risk was observed for increasing levels of IGF-I in women aged 55 or older, in the Ume\u00e5 cohort only (odds ratios of 1.00, 1.73, 1.76, 1.90; ptrend = 0.05). This effect weakened, however, when the analysis was restricted to subjects who did not use exogenous hormones for the treatment of menopausal symptoms. Levels of IGF-I and IGFBP-3 were not related to risk in younger women, recruited before age 50, contrary to observations from previous studies. In a subcohort where blood samples had been collected after at least four hours of fasting, breast cancer risk showed no clear associations with levels of insulin, IGFBP-1, or IGFBP-2. Conclusions: Our results do not confirm earlier findings of an association of plasma IGF-I levels with breast cancer risk especially in young women, but suggest a possible association with postmenopausal breast cancer risk, possibly among ERT/HRT users only. Our results do not support the hypothesis that elevated plasma insulin levels, and reduced levels of IGFBP-1 and IGFBP-2, are associated with increased breast cancer risk.", 
    "genre": "article", 
    "id": "sg:pub.10.1023/a:1015270324325", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1100917", 
        "issn": [
          "0957-5243", 
          "1573-7225"
        ], 
        "name": "Cancer Causes & Control", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "keywords": [
      "breast cancer risk", 
      "levels of IGF", 
      "cancer risk", 
      "IGFBP-3", 
      "IGFBP-1", 
      "IGFBP-2", 
      "postmenopausal breast cancer risk", 
      "incident breast cancer cases", 
      "IGF-binding protein-1", 
      "young women", 
      "insulin-like growth factor", 
      "prediagnostic plasma levels", 
      "IGF-binding proteins", 
      "plasma insulin levels", 
      "levels of insulin", 
      "subgroups of age", 
      "breast cancer cases", 
      "hours of fasting", 
      "HRT users", 
      "prospective cohort", 
      "insulin levels", 
      "prospective study", 
      "menopausal symptoms", 
      "plasma levels", 
      "plasma IGF", 
      "plasma concentrations", 
      "cancer cases", 
      "age 50", 
      "blood samples", 
      "IGF", 
      "possible association", 
      "blood donation", 
      "exogenous hormones", 
      "growth factor", 
      "clear association", 
      "insulin", 
      "protein 1", 
      "reduced levels", 
      "women", 
      "risk", 
      "cohort", 
      "possible relationship", 
      "association", 
      "IGFBPs", 
      "previous studies", 
      "subcohort", 
      "earlier findings", 
      "levels", 
      "symptoms", 
      "fasting", 
      "hormone", 
      "age", 
      "subgroups", 
      "treatment", 
      "total", 
      "study", 
      "Ume\u00e5", 
      "Malm\u00f6", 
      "subjects", 
      "hours", 
      "donation", 
      "findings", 
      "factors", 
      "control", 
      "cases", 
      "protein", 
      "southern Sweden", 
      "increase", 
      "effect", 
      "analysis", 
      "Sweden", 
      "hypothesis", 
      "concentration", 
      "results", 
      "samples", 
      "relationship", 
      "observations", 
      "users"
    ], 
    "name": "Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in Northern and Southern Sweden", 
    "pagination": "307-316", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021221270"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1015270324325"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12074500"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1015270324325", 
      "https://app.dimensions.ai/details/publication/pub.1021221270"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_360.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1023/a:1015270324325"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1015270324325'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1015270324325'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1015270324325'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1015270324325'


 

This table displays all metadata directly associated to this object as RDF triples.

303 TRIPLES      21 PREDICATES      126 URIs      110 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1015270324325 schema:about N09ca5b01bc0a401c8ab7850571f027c0
2 N0a77dea4fa2d47d197acfc2a91fae3bc
3 N0e48cfb1c3ea46bd8cab4912d0bd306a
4 N1b82de6a53dd401da7906e05908385c5
5 N5733bbbc952b48be901f11b36f05f7d7
6 N5d02766de83344ffa57e37d692c51e2e
7 N7ca529568bb54add895c84df70b762fb
8 N84b0970938c74ac597fd2e39c2faf234
9 N9bb14eca5777476485df7383440fc68c
10 Nc9302211ea5c4bdca0dd807b62456330
11 Ncefac90142b840e98aceacf1821f9ef8
12 Nf13f7ba5352f46818e2b24cebc093d94
13 Nfe09c894407247ff979befb0dfa91811
14 Nfe0b7053d1ff425b998ec24cc10aff12
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N94f0325a9f2e44a393904eb62b516ad4
18 schema:citation sg:pub.10.1007/bf00051703
19 sg:pub.10.1023/a:1005831013718
20 sg:pub.10.1023/a:1008903727238
21 sg:pub.10.1023/a:1009559014703
22 sg:pub.10.1023/a:1018789527533
23 sg:pub.10.1038/nm1097-1141
24 sg:pub.10.1038/sj.onc.1203349
25 sg:pub.10.1054/bjoc.2001.1899
26 schema:datePublished 2002-05
27 schema:datePublishedReg 2002-05-01
28 schema:description Objective: To examine the possible relationships of breast cancer risk to prediagnostic plasma levels of insulin; insulin-like growth factor-I (IGF-I); and IGF-binding proteins -1, -2, and -3. Methods: Within two prospective cohorts in Umeå and Malmö we measured plasma concentrations of insulin, IGF-I, and IGFBPs for a total of 513 incident breast cancer cases and 987 matched controls. Results: Globally, risk was unassociated with levels of IGF-I, IGFBP-3, or IGF-I adjusted for IGFBP-3. When breaking down the analysis by subgroups of age at blood donation, an increase in risk was observed for increasing levels of IGF-I in women aged 55 or older, in the Umeå cohort only (odds ratios of 1.00, 1.73, 1.76, 1.90; ptrend = 0.05). This effect weakened, however, when the analysis was restricted to subjects who did not use exogenous hormones for the treatment of menopausal symptoms. Levels of IGF-I and IGFBP-3 were not related to risk in younger women, recruited before age 50, contrary to observations from previous studies. In a subcohort where blood samples had been collected after at least four hours of fasting, breast cancer risk showed no clear associations with levels of insulin, IGFBP-1, or IGFBP-2. Conclusions: Our results do not confirm earlier findings of an association of plasma IGF-I levels with breast cancer risk especially in young women, but suggest a possible association with postmenopausal breast cancer risk, possibly among ERT/HRT users only. Our results do not support the hypothesis that elevated plasma insulin levels, and reduced levels of IGFBP-1 and IGFBP-2, are associated with increased breast cancer risk.
29 schema:genre article
30 schema:isAccessibleForFree false
31 schema:isPartOf N88f646892939456abdc209de9d608b47
32 N8bd839b84c2a4cc3a0e69de3f963a3d7
33 sg:journal.1100917
34 schema:keywords HRT users
35 IGF
36 IGF-binding protein-1
37 IGF-binding proteins
38 IGFBP-1
39 IGFBP-2
40 IGFBP-3
41 IGFBPs
42 Malmö
43 Sweden
44 Umeå
45 age
46 age 50
47 analysis
48 association
49 blood donation
50 blood samples
51 breast cancer cases
52 breast cancer risk
53 cancer cases
54 cancer risk
55 cases
56 clear association
57 cohort
58 concentration
59 control
60 donation
61 earlier findings
62 effect
63 exogenous hormones
64 factors
65 fasting
66 findings
67 growth factor
68 hormone
69 hours
70 hours of fasting
71 hypothesis
72 incident breast cancer cases
73 increase
74 insulin
75 insulin levels
76 insulin-like growth factor
77 levels
78 levels of IGF
79 levels of insulin
80 menopausal symptoms
81 observations
82 plasma IGF
83 plasma concentrations
84 plasma insulin levels
85 plasma levels
86 possible association
87 possible relationship
88 postmenopausal breast cancer risk
89 prediagnostic plasma levels
90 previous studies
91 prospective cohort
92 prospective study
93 protein
94 protein 1
95 reduced levels
96 relationship
97 results
98 risk
99 samples
100 southern Sweden
101 study
102 subcohort
103 subgroups
104 subgroups of age
105 subjects
106 symptoms
107 total
108 treatment
109 users
110 women
111 young women
112 schema:name Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in Northern and Southern Sweden
113 schema:pagination 307-316
114 schema:productId N4d3ba9af26864ed687a0e545cffa1200
115 N936dab21ea13486f951f8657325f5a41
116 Ncdacb6e64a7c4085b5133cd7bb629e90
117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021221270
118 https://doi.org/10.1023/a:1015270324325
119 schema:sdDatePublished 2022-10-01T06:32
120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
121 schema:sdPublisher N506399130a084fdc8f41335255e54c23
122 schema:url https://doi.org/10.1023/a:1015270324325
123 sgo:license sg:explorer/license/
124 sgo:sdDataset articles
125 rdf:type schema:ScholarlyArticle
126 N09ca5b01bc0a401c8ab7850571f027c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Humans
128 rdf:type schema:DefinedTerm
129 N0a77dea4fa2d47d197acfc2a91fae3bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Insulin-Like Growth Factor Binding Proteins
131 rdf:type schema:DefinedTerm
132 N0e48cfb1c3ea46bd8cab4912d0bd306a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Female
134 rdf:type schema:DefinedTerm
135 N145624a2bc4b4690b6ed7b83809294bb rdf:first sg:person.01253670741.91
136 rdf:rest N60ae0fe909924a16bd3330240211a35c
137 N1b82de6a53dd401da7906e05908385c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Age Factors
139 rdf:type schema:DefinedTerm
140 N1d6ba2ed7e264bd1bad2977b87ea0d50 rdf:first sg:person.01023564410.54
141 rdf:rest rdf:nil
142 N2baf1c2e70214cc7883d62817c136f88 rdf:first sg:person.0721051037.52
143 rdf:rest Nb79ee0e5f9744ec1a11d146e69562038
144 N4d3ba9af26864ed687a0e545cffa1200 schema:name pubmed_id
145 schema:value 12074500
146 rdf:type schema:PropertyValue
147 N506399130a084fdc8f41335255e54c23 schema:name Springer Nature - SN SciGraph project
148 rdf:type schema:Organization
149 N5733bbbc952b48be901f11b36f05f7d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Case-Control Studies
151 rdf:type schema:DefinedTerm
152 N5d02766de83344ffa57e37d692c51e2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Insulin
154 rdf:type schema:DefinedTerm
155 N60ae0fe909924a16bd3330240211a35c rdf:first sg:person.01313726246.87
156 rdf:rest N1d6ba2ed7e264bd1bad2977b87ea0d50
157 N6a35e0b274b249b7a82ac843d48a155e rdf:first sg:person.01305543702.17
158 rdf:rest Ne54e22e269e247c8807eca9dd022a15c
159 N7ca529568bb54add895c84df70b762fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Adult
161 rdf:type schema:DefinedTerm
162 N84b0970938c74ac597fd2e39c2faf234 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Insulin-Like Growth Factor I
164 rdf:type schema:DefinedTerm
165 N88f646892939456abdc209de9d608b47 schema:volumeNumber 13
166 rdf:type schema:PublicationVolume
167 N8bd839b84c2a4cc3a0e69de3f963a3d7 schema:issueNumber 4
168 rdf:type schema:PublicationIssue
169 N936dab21ea13486f951f8657325f5a41 schema:name doi
170 schema:value 10.1023/a:1015270324325
171 rdf:type schema:PropertyValue
172 N94f0325a9f2e44a393904eb62b516ad4 rdf:first sg:person.015420102437.43
173 rdf:rest N9642f73ab41643fb994de92b9ff518b3
174 N9642f73ab41643fb994de92b9ff518b3 rdf:first sg:person.01056300321.22
175 rdf:rest Nfa44a7b66d38453489f7ff2c998e9e14
176 N98079e4bdff143b594b4dfe685f2cb6e rdf:first sg:person.016465323374.03
177 rdf:rest N2baf1c2e70214cc7883d62817c136f88
178 N9bb14eca5777476485df7383440fc68c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Hormone Replacement Therapy
180 rdf:type schema:DefinedTerm
181 Nb79ee0e5f9744ec1a11d146e69562038 rdf:first sg:person.01051311312.39
182 rdf:rest N145624a2bc4b4690b6ed7b83809294bb
183 Nc9302211ea5c4bdca0dd807b62456330 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Sweden
185 rdf:type schema:DefinedTerm
186 Ncdacb6e64a7c4085b5133cd7bb629e90 schema:name dimensions_id
187 schema:value pub.1021221270
188 rdf:type schema:PropertyValue
189 Ncefac90142b840e98aceacf1821f9ef8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Breast Neoplasms
191 rdf:type schema:DefinedTerm
192 Ne54e22e269e247c8807eca9dd022a15c rdf:first sg:person.01345317212.46
193 rdf:rest N98079e4bdff143b594b4dfe685f2cb6e
194 Nf13f7ba5352f46818e2b24cebc093d94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Middle Aged
196 rdf:type schema:DefinedTerm
197 Nfa44a7b66d38453489f7ff2c998e9e14 rdf:first sg:person.01001561122.12
198 rdf:rest N6a35e0b274b249b7a82ac843d48a155e
199 Nfe09c894407247ff979befb0dfa91811 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Risk Factors
201 rdf:type schema:DefinedTerm
202 Nfe0b7053d1ff425b998ec24cc10aff12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Aged
204 rdf:type schema:DefinedTerm
205 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
206 schema:name Medical and Health Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
209 schema:name Clinical Sciences
210 rdf:type schema:DefinedTerm
211 sg:journal.1100917 schema:issn 0957-5243
212 1573-7225
213 schema:name Cancer Causes & Control
214 schema:publisher Springer Nature
215 rdf:type schema:Periodical
216 sg:person.01001561122.12 schema:affiliation grid-institutes:grid.4514.4
217 schema:familyName Manjer
218 schema:givenName Jonas
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001561122.12
220 rdf:type schema:Person
221 sg:person.01023564410.54 schema:affiliation grid-institutes:grid.12650.30
222 schema:familyName Hallmans
223 schema:givenName Göran
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023564410.54
225 rdf:type schema:Person
226 sg:person.01051311312.39 schema:affiliation grid-institutes:grid.4514.4
227 schema:familyName Janzon
228 schema:givenName Lars
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051311312.39
230 rdf:type schema:Person
231 sg:person.01056300321.22 schema:affiliation grid-institutes:grid.12650.30
232 schema:familyName Lundin
233 schema:givenName Eva
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056300321.22
235 rdf:type schema:Person
236 sg:person.01253670741.91 schema:affiliation grid-institutes:grid.17703.32
237 schema:familyName Riboli
238 schema:givenName Elio
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253670741.91
240 rdf:type schema:Person
241 sg:person.01305543702.17 schema:affiliation grid-institutes:grid.17703.32
242 schema:familyName Rinaldi
243 schema:givenName Sabina
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305543702.17
245 rdf:type schema:Person
246 sg:person.01313726246.87 schema:affiliation grid-institutes:grid.4514.4
247 schema:familyName Berglund
248 schema:givenName Göran
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313726246.87
250 rdf:type schema:Person
251 sg:person.01345317212.46 schema:affiliation grid-institutes:grid.17703.32
252 schema:familyName Biessy
253 schema:givenName Carine
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345317212.46
255 rdf:type schema:Person
256 sg:person.015420102437.43 schema:affiliation grid-institutes:grid.17703.32
257 schema:familyName Kaaks
258 schema:givenName Rudolf
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015420102437.43
260 rdf:type schema:Person
261 sg:person.016465323374.03 schema:affiliation grid-institutes:grid.12650.30
262 schema:familyName Söderberg
263 schema:givenName Stefan
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016465323374.03
265 rdf:type schema:Person
266 sg:person.0721051037.52 schema:affiliation grid-institutes:grid.12650.30
267 schema:familyName Lenner
268 schema:givenName Per
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721051037.52
270 rdf:type schema:Person
271 sg:pub.10.1007/bf00051703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010664099
272 https://doi.org/10.1007/bf00051703
273 rdf:type schema:CreativeWork
274 sg:pub.10.1023/a:1005831013718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049782404
275 https://doi.org/10.1023/a:1005831013718
276 rdf:type schema:CreativeWork
277 sg:pub.10.1023/a:1008903727238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022593002
278 https://doi.org/10.1023/a:1008903727238
279 rdf:type schema:CreativeWork
280 sg:pub.10.1023/a:1009559014703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039331289
281 https://doi.org/10.1023/a:1009559014703
282 rdf:type schema:CreativeWork
283 sg:pub.10.1023/a:1018789527533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002705289
284 https://doi.org/10.1023/a:1018789527533
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/nm1097-1141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016201589
287 https://doi.org/10.1038/nm1097-1141
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/sj.onc.1203349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051002438
290 https://doi.org/10.1038/sj.onc.1203349
291 rdf:type schema:CreativeWork
292 sg:pub.10.1054/bjoc.2001.1899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028451934
293 https://doi.org/10.1054/bjoc.2001.1899
294 rdf:type schema:CreativeWork
295 grid-institutes:grid.12650.30 schema:alternateName University of Umeå, Sweden
296 schema:name University of Umeå, Sweden
297 rdf:type schema:Organization
298 grid-institutes:grid.17703.32 schema:alternateName Unit of Nutrition and Cancer, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France
299 schema:name Unit of Nutrition and Cancer, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France
300 rdf:type schema:Organization
301 grid-institutes:grid.4514.4 schema:alternateName Lund University, UMAS, 205 02, Malmö, Sweden
302 schema:name Lund University, UMAS, 205 02, Malmö, Sweden
303 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...