Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in Northern and Southern Sweden View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-05

AUTHORS

Rudolf Kaaks, Eva Lundin, Jonas Manjer, Sabina Rinaldi, Carine Biessy, Stefan Söderberg, Per Lenner, Lars Janzon, Elio Riboli, Göran Berglund, Göran Hallmans

ABSTRACT

Objective: To examine the possible relationships of breast cancer risk to prediagnostic plasma levels of insulin; insulin-like growth factor-I (IGF-I); and IGF-binding proteins -1, -2, and -3. Methods: Within two prospective cohorts in Umeå and Malmö we measured plasma concentrations of insulin, IGF-I, and IGFBPs for a total of 513 incident breast cancer cases and 987 matched controls. Results: Globally, risk was unassociated with levels of IGF-I, IGFBP-3, or IGF-I adjusted for IGFBP-3. When breaking down the analysis by subgroups of age at blood donation, an increase in risk was observed for increasing levels of IGF-I in women aged 55 or older, in the Umeå cohort only (odds ratios of 1.00, 1.73, 1.76, 1.90; ptrend = 0.05). This effect weakened, however, when the analysis was restricted to subjects who did not use exogenous hormones for the treatment of menopausal symptoms. Levels of IGF-I and IGFBP-3 were not related to risk in younger women, recruited before age 50, contrary to observations from previous studies. In a subcohort where blood samples had been collected after at least four hours of fasting, breast cancer risk showed no clear associations with levels of insulin, IGFBP-1, or IGFBP-2. Conclusions: Our results do not confirm earlier findings of an association of plasma IGF-I levels with breast cancer risk especially in young women, but suggest a possible association with postmenopausal breast cancer risk, possibly among ERT/HRT users only. Our results do not support the hypothesis that elevated plasma insulin levels, and reduced levels of IGFBP-1 and IGFBP-2, are associated with increased breast cancer risk. More... »

PAGES

307-316

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1015270324325

DOI

http://dx.doi.org/10.1023/a:1015270324325

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021221270

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12074500


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65 fasting
66 findings
67 growth factor
68 hormone
69 hours
70 hours of fasting
71 hypothesis
72 incident breast cancer cases
73 increase
74 insulin
75 insulin levels
76 insulin-like growth factor
77 levels
78 levels of IGF
79 levels of insulin
80 menopausal symptoms
81 observations
82 plasma IGF
83 plasma concentrations
84 plasma insulin levels
85 plasma levels
86 possible association
87 possible relationship
88 postmenopausal breast cancer risk
89 prediagnostic plasma levels
90 previous studies
91 prospective cohort
92 prospective study
93 protein
94 protein 1
95 reduced levels
96 relationship
97 results
98 risk
99 samples
100 southern Sweden
101 study
102 subcohort
103 subgroups
104 subgroups of age
105 subjects
106 symptoms
107 total
108 treatment
109 users
110 women
111 young women
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