Effective Solitary Hyperthermia Treatment of Malignant Glioma Using Stick Type CMC-magnetite. In vivo Study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-02

AUTHORS

Takanari Ohno, Toshihiko Wakabayashi, Atsuhito Takemura, Jun Yoshida, Akira Ito, Masashige Shinkai, Hiroyuki Honda, Takeshi Kobayashi

ABSTRACT

Various kinds of hyperthermic treatment for malignant glioma had been inhibited due to both their incomplete feverish action and strict cooling effect of the brain. The author shows an effective results of hyperthermia for the treatment of malignant glioma in an in vivo study using stick type carboxymethylcellulose (CMC)-magnetite, a newly manufactured magnetite-product. A stick type CMC-magnetite, containing magnetite particles, was inserted into the T-9 glioma in the rat brain stereotactically, and the rats were exposed to an alternative magnetic field (AMF). The application time of AMF, which measured 88.9 kHz and 380 Oe, was 30 min a day. The rats were divided into three groups: three AMF applications (group I), one AMF application (group II) and no application but only injection of CMC-magnetite (control). As a result, the mean survival in days of these three groups measured 44.2+/-10.9 (group I), 17.0+/-1.5 (group II) and 14.4+/-1.5 (control). This investigation showed both significant effectiveness in attacking malignant glioma and significant prolonging of the survival time in rats. It is also a characteristic feature of the magnetite particles to spread through the tumor diffusely after three applications of AMF. This feature seemed to be one of the main factors that caused greater hyperthermic effect on glioma in this study. This method of hyperthermic treatment could be a useful strategy in the treatment of malignant glioma. More... »

PAGES

233-239

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1015080808031

DOI

http://dx.doi.org/10.1023/a:1015080808031

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004287402

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12061729


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