Genetic Susceptibility to Tuberculosis: From Monogenic to Polygenic Inheritance View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-12

AUTHORS

Alexandre Alcaïs, Natascha Remus, Laurent Abel, Jean-Laurent Casanova

ABSTRACT

Summary. Tuberculosis is re-emerging as a leading public health problem worldwide, largely due to the lack of a fully protective vaccine, the acquired immunodeficiency associated with HIV-co-infection and the increasing number of drug-resistant mycobacteria. There is substantial epidemiological evidence that the host genetic make-up affects the development of clinical tuberculosis in humans. Here we review population-based and patient-based molecular studies that have implicated various genes in polygenic and monogenic susceptibility to mycobacterial disease. We further discuss the possibility of a continuous spectrum between these two poles of tuberculosis genetics. More... »

PAGES

237-246

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1012917124511

DOI

http://dx.doi.org/10.1023/a:1012917124511

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034584529


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