Release of TNF-α from Lipopolysaccharide (LPS)-Stimulated Kupffer Cells in Serum- and Nutrient-Free Medium View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-10

AUTHORS

Annette Zipfel, Martin Schenk, Birgit Metzdorf, Christiane Bode, Richard Viebahn

ABSTRACT

In monocytes/macrophages LPS stimulation occurs by the binding of LPS and the serum component LPS-binding protein (LBP) to CD14. This study was conducted to investigate whether this mechanism also occurs in Kupffer cells. Rat Kupffer cells were stimulated for up to 8 h by LPS (0, 100 ng/ml, 10 microg/ml) in RPMI medium or in nutrient-free Krebs-Henseleit (KH) buffer. Some incubations were performed without serum, while in others serum was provided. TNF-alpha concentrations of the supernatants were measured by ELISA. LPS stimulation of Kupffer cells yielded the following results. In KH without any additives a considerable amount of TNF-alpha was released. Incubation in RPMI without serum caused twice as much TNF-alpha to be released as when KH was used. The addition of autologous serum to RPMI did not increase TNF-alpha response. These results provide evidence that a substantial part of TNF-alpha release by LPS-stimulated Kupffer cells occurs in a serum- and thus LBP-independent way. More... »

PAGES

287-292

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1012856408531

DOI

http://dx.doi.org/10.1023/a:1012856408531

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038087619

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11820455


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