Ets-1 is involved in transcriptional regulation of the chick inducible nitric oxide synthase gene in embryonic ventricular myoctyes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-10

AUTHORS

Toshiyuki Takahashi, Yasuyuki Sugishita, Koh-ichiro Kinugawa, Tatsuya Shimizu, Atsushi Yao, Kazumasa Harada, Hiroshi Matsui, Ryozo Nagai

ABSTRACT

In order to elucidate roles of Ets family of transcription factors in transcriptional activation of inducible nitric oxide synthase (iNOS) genes, we analyzed the chick iNOS gene expression in cultured chick embryonic ventricular myocytes (CEVM). Deletional analysis and site-directed mutagenesis demonstrated that both the Ets/PEA3 site (–221 to –216 bp) and the κB site (–101 to –93 bp) of the 5′-flanking region of the chick iNOS gene were involved in the maximal activation of the lipopolysaccharide (LPS)-induced expression of the reporter (luciferase) gene, although the proximal κB site played the more essential role. Electrophoretic mobility shift assay revealed that LPS augmented the nuclear protein bindings to the Ets/PEA3 as well as κB motifs. Ets-1, one of the Ets proteins, was suggested to be bound to the Ets/PEA3 oligonucleotide. By Northern blot analysis, LPS was shown to induce iNOS mRNA in CEVM, along with a preceding increase in the levels of c-ets-1 mRNA. Ets-1 may be involved in the iNOS gene transcription in CEVM, presumably through interacting with the NF-κB. More... »

PAGES

57-65

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1012781618109

DOI

http://dx.doi.org/10.1023/a:1012781618109

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044781034

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11768239


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