Pharmacokinetic Analysis of Benzodiazepine Receptor Binding of [123I]Iomazenil in Human Brain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-08

AUTHORS

Kiyomi Ito, Toshimitsu Momose, Hajime Kotaki, Yoshiki Kojima, Koujirou Yamamoto, Masataka Katashima, Yasufumi Sawada, Yasuhito Sasaki, Tatsuji Iga

ABSTRACT

Purpose. The purpose of this study is to evaluate the central benzodiazepine (BZP) receptor binding of iomazenil (IMZ) by pharmacokinetic analysis and to establish a methodology for the diagnosis of CNS disorders with abnormalities in BZP receptor binding.Methods. BZP receptor binding of IMZ was analyzed kinetically using plasma concentration-time profiles and dynamic single photon emission computed tomography (SPECT) data obtained after the intravenous administration of IMZ to patients with neuropsychiatric diseases. The analysis was based on a 3-compartmental model including the processes of both blood-brain barrier (BBB) transport and BZP receptor binding.Results. Hydrolized metabolite of IMZ was detected in plasma, indicating the need for separation by HPLC. The BBB influx clearance and the receptor binding potential of IMZ in the medial temporal region was reduced in the epileptic patient.Conclusions. Our findings suggest the possibility of detecting the epileptic focus by using our method. More... »

PAGES

999-1003

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1012188909100

DOI

http://dx.doi.org/10.1023/a:1012188909100

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037265727

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9279879


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