Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-10

AUTHORS

C. J. Hawkins, J. Silke, A. M. Verhagen, R. Foster, P. G. Ekert, D. M. Ashley

ABSTRACT

We have reconstituted the Apaf-1-activated apoptosis mechanism in Sacchromyces cerevisiae such that the presence of a constitutively active form of Apaf-1 together with both Caspase-9 and Caspase-3 results in yeast death. This system is a good model of the Apaf-1-activated pathway in mammalian cells: MIHA (XIAP/hILP), and to a lesser degree MIHB (c-IAP1/HIAP2) and MIHC (c-IAP-2/HIAP1) can inhibit caspases in this system, and protection by IAPs (inhibitor of apoptosis) can be abrogated by coexpression of the Drosophila pro-apoptotic proteins HID and GRIM or the mammalian protein DIABLO/Smac. Using this system we demonstrate that unlike DIABLO/Smac, other proteins which interact with mammalian IAPs (TAB-1, Zap-1, Traf-1 and Traf-2) do not act to antagonise IAP- mediated caspase inhibition. More... »

PAGES

331-338

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1011329917895

DOI

http://dx.doi.org/10.1023/a:1011329917895

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011713602

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11483856


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