OKT3 and IL-2 Treatment for Purging of the Latent HIV-1 Reservoir in Vivo Results in Selective Long-Lasting CD4+ T Cell ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-05

AUTHORS

R. M. E. Van Praag, J. M. Prins, M. T. L. Roos, P. Th. A. Schellekens, I. J. M. Ten Berge, S-L. Yong, H. Schuitemaker, A. J. M. Eerenberg, S. Jurriaans, F. De Wolf, C. H. Fox, J. Goudsmit, F. Miedema, J. M. A. Lange

ABSTRACT

Activation of resting T cells has been proposed to purge the reservoir of HIV-1-infected resting CD4+ T cells. We therefore treated three HIV-1-infected patients on antiretroviral therapy with OKT3, a CD3 monoclonal antibody, and recombinant human IL-2. Here we report the profound and partially long-lasting host responses induced by the OKT3 and IL-2 treatment. OKT3/IL-2 induced a strong but transient release of plasma cytokines and chemokines. The percentage CD4+ and CD8+ cells in the blood expressing the activation marker CD38 transiently increased to almost 100%, and in lymph nodes we “observed” a 10-fold increase in the number of dividing Ki67+ cells and increased numbers of apoptotic cells. Following OKT3/IL-2 treatment, a long-lasting depletion of CD4+ cells in the peripheral blood and lymph nodes occurred, suggesting the physical deletion of these cells. Increases in CD4+T cell numbers during the two year followup period were due mainly to increased memory cell numbers. CD8+ cells were also depleted in the blood, but less severely in lymph nodes, and returned to baseline levels within several weeks. More... »

PAGES

218-226

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1011091300321

DOI

http://dx.doi.org/10.1023/a:1011091300321

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038615971

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11403229


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