Human Mast Cell Apoptosis Is Regulated Through Bcl-2 and Bcl-XL View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-05

AUTHORS

Yoseph A. Mekori, Alasdair M. Gilfillan, Cem Akin, Karin Hartmann, Dean D. Metcalfe

ABSTRACT

It is well established that human mast cell proliferation and maturation are regulated by kit ligand (stem cell factor). Little is known, however, about how these two processes are negatively regulated and thus, how mast cell number is controlled in normal and pathologic conditions. We therefore first hypothesized that SCF-dependent human mast cells would undergo programmed cell death (apoptosis) on removal of SCF as has been shown for growth factor-dependent rodent mast cells. We then examined whether SCF acts as a survival factor through the regulation of the bcl-2 family of apoptosis-regulatory genes. As hypothesized, elimination of SCF from primary peripheral blood-derived human mast cell cultures resulted in a significant apoptotic process. During apoptosis, down-regulation of the two apoptosis-regulatory proteins Bcl-2 and Bcl-XL was observed. Moreover, a deregulated expression of these two proteins was found in two human mast cell lines which are SCF-independent. Thus, SCF functions as a survival factor by repressing apoptosis of human mast cells through Bcl-2 and Bcl-XL. Deregulated expression of these antiapoptotic proteins may contribute to proliferation and accumulation of mast cells in certain forms of systemic mast cell disorders. More... »

PAGES

171-174

References to SciGraph publications

  • 1999. Mast Cell Apoptosis and Its Regulation in SIGNAL TRANSDUCTION IN MAST CELLS AND BASOPHILS
  • 2000-06. A Role for Bax in the Regulation of Apoptosis in Mouse Mast Cells in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1023/a:1011083031272

    DOI

    http://dx.doi.org/10.1023/a:1011083031272

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038435924

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11403223


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