Autistic Behavior, FMR1 Protein, and Developmental Trajectories in Young Males with Fragile X Syndrome View Full Text


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Article Info

DATE

2001-04

AUTHORS

Donald B. Bailey, Deborah D. Hatton, Martie Skinner, Gary Mesibov

ABSTRACT

In the context of a longitudinal study, we assessed the relationship between ratings of autistic behavior, FMR1 protein expression (FMRP), and the developmental trajectories of 55 young males with fragile X syndrome. Autistic behavior, as measured by the Childhood Autism Rating Scale, was not related to FMRP expression. However, autistic behavior was a significant predictor of both developmental status and developmental change. Boys with both autistic behavior and fragile X syndrome functioned at significantly lower levels of development and grew at significantly slower rates than those without autistic behavior. FMRP expression accounted for less variance in developmental level than did autistic behavior, and was not significantly related to slope (developmental change over time). No autistic behavior x FMRP interaction was found. More... »

PAGES

165-174

References to SciGraph publications

  • 1991-12. A comparison and evaluation of three commonly used autism scales in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • 2000-02. Early Development, Temperament, and Functional Impairment in Autism and Fragile X Syndrome in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • 1998-10. Autism: The Point of View from Fragile X Studies in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • 1990-06. Differences in adaptive functioning among people with autism or mental retardation in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • 1996-04. State of the science in autism: Report to the National institutes of health in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • 1996-12. Adaptive and intellectual functioning in autistic and nonautistic retarded children in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • 1998-12. Autistic Behavior in Young Boys with Fragile X Syndrome in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1023/a:1010747131386

    DOI

    http://dx.doi.org/10.1023/a:1010747131386

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017330822

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11450815


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