Cyclooxygenase-2 Expression in Barrett's Esophagus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-04

AUTHORS

Hossam M. Kandil, Gordon Tanner, Walter Smalley, Susan Halter, Aramandala Radhika, Raymond N. Dubois

ABSTRACT

Barrett's epithelium is a recognized premalignant condition for esophageal adenocarcinoma. Nonsteroidal antiinflammatory drugs (NSAIDs) decrease the relative risk of colon cancer in humans and the esophageal tumor load in carcinogen-treated mice. Previous studies provided conflicting results for COX-2 activity in Barrett's mucosa. Pinch mucosal biopsies were collected from Barrett's and adjacent normal esophageal mucosa from 17 patients with Barrett's esophagus. Low-grade dysplasia was found in seven patients. COX-2 protein was undetectable in normal esophageal mucosa. COX-1 protein expression did not vary between normal and Barrett's epithelium. Increased COX-2 protein was detected in Barrett's epithelium in seven patients (41%) but did not differ with or without dysplasia (43% vs 40%). In conclusion, COX-2 protein is increased in 41% of patients with Barrett's epithelium compared to normal esophageal mucosa but did not differ with or without dysplasia. COX-2 induction may be an early event in the development of Barrett's esophagus. More... »

PAGES

785-789

References to SciGraph publications

  • 1994-01. Towards a better aspirin in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1023/a:1010700400960

    DOI

    http://dx.doi.org/10.1023/a:1010700400960

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11330414


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