Biophenotypes and survival of BRCA1 and TP53 deleted breast cancer in young women View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-03

AUTHORS

Patrizia Querzoli, Giuseppe Albonico, Maria Grazia di Iasio, Stefano Ferretti, Rosa Rinaldi, Anna Cariello, Massimo Pedriali, Maurizio Matteuzzi, Iva Maestri, Italo Nenci

ABSTRACT

The aim of this study was to examine the loss of heterozygosity (LOH) of BRCA1 (17q21) and TP53 (17p13.1) in early-onset breast cancer patients; to correlate biopathological characteristics with molecular alterations; and to investigate the survival of LOH-related cancers. BRCA1 and TP53 LOH were evaluated in 78 early-onset breast cancers (< or = 40 years, Group 1) and 80 patients with age > 55 years (Group 2). Cases were characterized for multiple biological markers (ER, PR, proliferation index (PI), NEU and p53). LOH was carried out on microdissected paraffin embedded tissues; microsatellites D17S855 (BRCA1) and D17S786 (TP53) were amplified by fluorescent PCR and analyzed by an automated DNA sequencer. Early-onset breast cancers showed a higher frequency of ductal histotype (89.7% vs. 56.3% p < 0.001), node-positive (53.8% vs. 38.7%), larger size (p = 0.017), higher mitotic rate (p = 0.025), higher nuclear and final grade (p = 0.01 and p = 0.001, respectively). D17S855 LOH was 32.8% in group 1 vs. 21% in group 2; D17S786 LOH was 50.7% vs. 31.3% (p = 0.03), respectively. BRCA1 LOH was correlated with higher PI (p = 0.032) and higher p53 expression (p < 0.001) in group 1 and with higher NEU expression (p = 0.028) in group 2. TP53 LOH was correlated with p53 overexpression (p = 0.03) in group 1. A worse clinical outcome in early-onset LOH related cancers emerged from follow-up data: TP53 and BRCA1 LOH were associated with a shorter relapse free interval (RFI) (p = 0.03) and a poorer overall survival (OS) (p = 0.04), respectively. This study underlines different biological profiles in the two age groups investigated, probably reflecting different mechanisms of carcinogenesis. In accordance with adverse histopathological features in early-onset patients, LOH-related cancers have an unfavorable prognosis. More... »

PAGES

135-142

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1010643515095

DOI

http://dx.doi.org/10.1023/a:1010643515095

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044881763

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11437099


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Ductal, Breast", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Lobular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, BRCA1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Italy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Loss of Heterozygosity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Ferrara", 
          "id": "https://www.grid.ac/institutes/grid.8484.0", 
          "name": [
            "Department of Experimental and Diagnostic Medicine, Section of Morbid Anatomy, Histopathology and Cytopathology, Ferrara University, Ferrara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Querzoli", 
        "givenName": "Patrizia", 
        "id": "sg:person.01117275052.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117275052.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ferrara", 
          "id": "https://www.grid.ac/institutes/grid.8484.0", 
          "name": [
            "Department of Experimental and Diagnostic Medicine, Section of Morbid Anatomy, Histopathology and Cytopathology, Ferrara University, Ferrara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Albonico", 
        "givenName": "Giuseppe", 
        "id": "sg:person.01027055113.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027055113.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ferrara", 
          "id": "https://www.grid.ac/institutes/grid.8484.0", 
          "name": [
            "Department of Experimental and Diagnostic Medicine, Section of Morbid Anatomy, Histopathology and Cytopathology, Ferrara University, Ferrara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iasio", 
        "givenName": "Maria Grazia di", 
        "id": "sg:person.0651263412.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651263412.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ferrara", 
          "id": "https://www.grid.ac/institutes/grid.8484.0", 
          "name": [
            "Department of Experimental and Diagnostic Medicine, Section of Morbid Anatomy, Histopathology and Cytopathology, Ferrara University, Ferrara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferretti", 
        "givenName": "Stefano", 
        "id": "sg:person.015013022320.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015013022320.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ferrara", 
          "id": "https://www.grid.ac/institutes/grid.8484.0", 
          "name": [
            "Department of Experimental and Diagnostic Medicine, Section of Morbid Anatomy, Histopathology and Cytopathology, Ferrara University, Ferrara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rinaldi", 
        "givenName": "Rosa", 
        "id": "sg:person.01356425051.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356425051.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Oncology, \u2018S. Maria delle Grazie\u2019 Hospital, Ravenna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cariello", 
        "givenName": "Anna", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ferrara", 
          "id": "https://www.grid.ac/institutes/grid.8484.0", 
          "name": [
            "Department of Experimental and Diagnostic Medicine, Section of Morbid Anatomy, Histopathology and Cytopathology, Ferrara University, Ferrara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pedriali", 
        "givenName": "Massimo", 
        "id": "sg:person.01336457446.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336457446.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ferrara", 
          "id": "https://www.grid.ac/institutes/grid.8484.0", 
          "name": [
            "Department of Experimental and Diagnostic Medicine, Section of Morbid Anatomy, Histopathology and Cytopathology, Ferrara University, Ferrara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matteuzzi", 
        "givenName": "Maurizio", 
        "id": "sg:person.01026557025.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026557025.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ferrara", 
          "id": "https://www.grid.ac/institutes/grid.8484.0", 
          "name": [
            "Department of Experimental and Diagnostic Medicine, Section of Morbid Anatomy, Histopathology and Cytopathology, Ferrara University, Ferrara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maestri", 
        "givenName": "Iva", 
        "id": "sg:person.0652524225.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652524225.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ferrara", 
          "id": "https://www.grid.ac/institutes/grid.8484.0", 
          "name": [
            "Department of Experimental and Diagnostic Medicine, Section of Morbid Anatomy, Histopathology and Cytopathology, Ferrara University, Ferrara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nenci", 
        "givenName": "Italo", 
        "id": "sg:person.01151636651.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151636651.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bjc.1997.223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001925195", 
          "https://doi.org/10.1038/bjc.1997.223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1997.223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001925195", 
          "https://doi.org/10.1038/bjc.1997.223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2264(199703)18:3<181::aid-gcc5>3.0.co;2-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003967676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(93)92407-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009213834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1991.tb00229.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010222506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1991.tb00229.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010222506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19951215)76:12<2510::aid-cncr2820761216>3.0.co;2-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010970205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1005853022804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013801113", 
          "https://doi.org/10.1023/a:1005853022804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19980701)83:1<89::aid-cncr12>3.0.co;2-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014443597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19960215)77:4<697::aid-cncr16>3.0.co;2-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016399570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00666584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016575262", 
          "https://doi.org/10.1007/bf00666584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00666584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016575262", 
          "https://doi.org/10.1007/bf00666584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0010-468x(72)90019-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017943682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0010-468x(72)90019-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017943682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)64441-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017978835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0495-444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018646090", 
          "https://doi.org/10.1038/ng0495-444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19970807)72:4<599::aid-ijc8>3.0.co;2-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019043939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-9525(99)01930-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022328573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00666204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022493002", 
          "https://doi.org/10.1007/bf00666204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00666204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022493002", 
          "https://doi.org/10.1007/bf00666204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1989.137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023936240", 
          "https://doi.org/10.1038/bjc.1989.137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1989.137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023936240", 
          "https://doi.org/10.1038/bjc.1989.137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2559.1999.00619.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025224829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0959-8049(95)00399-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026047657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/mp.51.5.237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027236776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/mp.51.5.237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027236776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.6.11.1029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032748231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1993.236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033771512", 
          "https://doi.org/10.1038/bjc.1993.236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1993.236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033771512", 
          "https://doi.org/10.1038/bjc.1993.236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19960101)77:1<97::aid-cncr16>3.0.co;2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034491633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1997.tb00550.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035358434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1997.tb00550.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035358434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(97)07065-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036503442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/106689699600400206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037563821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/106689699600400206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037563821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037629099", 
          "https://doi.org/10.1038/bjc.1996.632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037629099", 
          "https://doi.org/10.1038/bjc.1996.632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9896(199605)179:1<121::aid-path536>3.0.co;2-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039476485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9896(199605)179:1<121::aid-path536>3.0.co;2-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039476485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7545954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041365117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)79248-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045644349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0046-8177(93)90157-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046207125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(20000315)88:6<1393::aid-cncr17>3.0.co;2-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052099187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1023/a:1008340723974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056303291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2270482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062529993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074361782", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074549511", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082602599", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083084088", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083187481", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.5.1642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083260934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083347103", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-03", 
    "datePublishedReg": "2001-03-01", 
    "description": "The aim of this study was to examine the loss of heterozygosity (LOH) of BRCA1 (17q21) and TP53 (17p13.1) in early-onset breast cancer patients; to correlate biopathological characteristics with molecular alterations; and to investigate the survival of LOH-related cancers. BRCA1 and TP53 LOH were evaluated in 78 early-onset breast cancers (< or = 40 years, Group 1) and 80 patients with age > 55 years (Group 2). Cases were characterized for multiple biological markers (ER, PR, proliferation index (PI), NEU and p53). LOH was carried out on microdissected paraffin embedded tissues; microsatellites D17S855 (BRCA1) and D17S786 (TP53) were amplified by fluorescent PCR and analyzed by an automated DNA sequencer. Early-onset breast cancers showed a higher frequency of ductal histotype (89.7% vs. 56.3% p < 0.001), node-positive (53.8% vs. 38.7%), larger size (p = 0.017), higher mitotic rate (p = 0.025), higher nuclear and final grade (p = 0.01 and p = 0.001, respectively). D17S855 LOH was 32.8% in group 1 vs. 21% in group 2; D17S786 LOH was 50.7% vs. 31.3% (p = 0.03), respectively. BRCA1 LOH was correlated with higher PI (p = 0.032) and higher p53 expression (p < 0.001) in group 1 and with higher NEU expression (p = 0.028) in group 2. TP53 LOH was correlated with p53 overexpression (p = 0.03) in group 1. A worse clinical outcome in early-onset LOH related cancers emerged from follow-up data: TP53 and BRCA1 LOH were associated with a shorter relapse free interval (RFI) (p = 0.03) and a poorer overall survival (OS) (p = 0.04), respectively. This study underlines different biological profiles in the two age groups investigated, probably reflecting different mechanisms of carcinogenesis. In accordance with adverse histopathological features in early-onset patients, LOH-related cancers have an unfavorable prognosis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1023/a:1010643515095", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "66"
      }
    ], 
    "name": "Biophenotypes and survival of BRCA1 and TP53 deleted breast cancer in young women", 
    "pagination": "135-142", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d5c8e27349fc85c10996b080d6ee5abc4ccec2fb73d3d2c367e14ac852846248"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11437099"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1010643515095"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044881763"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1010643515095", 
      "https://app.dimensions.ai/details/publication/pub.1044881763"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000501.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1023/A:1010643515095"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1010643515095'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1010643515095'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1010643515095'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1010643515095'


 

This table displays all metadata directly associated to this object as RDF triples.

319 TRIPLES      21 PREDICATES      85 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1010643515095 schema:about N0d9af7173ae14f8f9c74e8f00af841b8
2 N15dc11aaf1044d3cb33c4b42ff74c834
3 N3819a0d7ed36491da245d472c4c9764c
4 N4b2924d620344b2bbfb0055eae3363f1
5 N9e056ec1e7894991bf3af6bc24675605
6 Na40e79e52f8f473298f94dedd68f7a8b
7 Nab5fca82062f4e3a86f052a16dfd8b4c
8 Nacfe3e094026463d89bfa39cac99ee7f
9 Nb3a54a7a9e934168904c7063896ef677
10 Nc73e2b7c942c43d0940a9d5c4be3b4de
11 Nd50fc771d68641dbaecc934939f3ec0c
12 Ne11ddf3a1769445586b2652ab944938a
13 Nf3265ae7bdaa424bad56a516a9f0e395
14 Nfa3c2faf55484af58cb4b0217b603336
15 Nfba5504944774565a0a74e79783c4ba3
16 Nfe3fb46026a4466f9ed07341c2c6b029
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author Nc85db537683a416bb40babafffb8c6ef
20 schema:citation sg:pub.10.1007/bf00666204
21 sg:pub.10.1007/bf00666584
22 sg:pub.10.1023/a:1005853022804
23 sg:pub.10.1038/bjc.1989.137
24 sg:pub.10.1038/bjc.1993.236
25 sg:pub.10.1038/bjc.1996.632
26 sg:pub.10.1038/bjc.1997.223
27 sg:pub.10.1038/ng0495-444
28 https://app.dimensions.ai/details/publication/pub.1074361782
29 https://app.dimensions.ai/details/publication/pub.1074549511
30 https://app.dimensions.ai/details/publication/pub.1082602599
31 https://app.dimensions.ai/details/publication/pub.1083084088
32 https://app.dimensions.ai/details/publication/pub.1083187481
33 https://app.dimensions.ai/details/publication/pub.1083347103
34 https://doi.org/10.1002/(sici)1096-9896(199605)179:1<121::aid-path536>3.0.co;2-d
35 https://doi.org/10.1002/(sici)1097-0142(19960101)77:1<97::aid-cncr16>3.0.co;2-3
36 https://doi.org/10.1002/(sici)1097-0142(19960215)77:4<697::aid-cncr16>3.0.co;2-w
37 https://doi.org/10.1002/(sici)1097-0142(19980701)83:1<89::aid-cncr12>3.0.co;2-8
38 https://doi.org/10.1002/(sici)1097-0142(20000315)88:6<1393::aid-cncr17>3.0.co;2-p
39 https://doi.org/10.1002/(sici)1097-0215(19970807)72:4<599::aid-ijc8>3.0.co;2-l
40 https://doi.org/10.1002/(sici)1098-2264(199703)18:3<181::aid-gcc5>3.0.co;2-y
41 https://doi.org/10.1002/1097-0142(19951215)76:12<2510::aid-cncr2820761216>3.0.co;2-q
42 https://doi.org/10.1016/0010-468x(72)90019-0
43 https://doi.org/10.1016/0046-8177(93)90157-c
44 https://doi.org/10.1016/0140-6736(93)92407-k
45 https://doi.org/10.1016/0959-8049(95)00399-4
46 https://doi.org/10.1016/s0140-6736(05)64441-8
47 https://doi.org/10.1016/s0140-6736(05)79248-5
48 https://doi.org/10.1016/s0140-6736(97)07065-7
49 https://doi.org/10.1016/s0168-9525(99)01930-7
50 https://doi.org/10.1023/a:1008340723974
51 https://doi.org/10.1046/j.1365-2559.1999.00619.x
52 https://doi.org/10.1101/gr.6.11.1029
53 https://doi.org/10.1111/j.1365-2559.1991.tb00229.x
54 https://doi.org/10.1111/j.1699-0463.1997.tb00550.x
55 https://doi.org/10.1126/science.2270482
56 https://doi.org/10.1126/science.7545954
57 https://doi.org/10.1136/mp.51.5.237
58 https://doi.org/10.1177/106689699600400206
59 https://doi.org/10.1200/jco.1998.16.5.1642
60 schema:datePublished 2001-03
61 schema:datePublishedReg 2001-03-01
62 schema:description The aim of this study was to examine the loss of heterozygosity (LOH) of BRCA1 (17q21) and TP53 (17p13.1) in early-onset breast cancer patients; to correlate biopathological characteristics with molecular alterations; and to investigate the survival of LOH-related cancers. BRCA1 and TP53 LOH were evaluated in 78 early-onset breast cancers (< or = 40 years, Group 1) and 80 patients with age > 55 years (Group 2). Cases were characterized for multiple biological markers (ER, PR, proliferation index (PI), NEU and p53). LOH was carried out on microdissected paraffin embedded tissues; microsatellites D17S855 (BRCA1) and D17S786 (TP53) were amplified by fluorescent PCR and analyzed by an automated DNA sequencer. Early-onset breast cancers showed a higher frequency of ductal histotype (89.7% vs. 56.3% p < 0.001), node-positive (53.8% vs. 38.7%), larger size (p = 0.017), higher mitotic rate (p = 0.025), higher nuclear and final grade (p = 0.01 and p = 0.001, respectively). D17S855 LOH was 32.8% in group 1 vs. 21% in group 2; D17S786 LOH was 50.7% vs. 31.3% (p = 0.03), respectively. BRCA1 LOH was correlated with higher PI (p = 0.032) and higher p53 expression (p < 0.001) in group 1 and with higher NEU expression (p = 0.028) in group 2. TP53 LOH was correlated with p53 overexpression (p = 0.03) in group 1. A worse clinical outcome in early-onset LOH related cancers emerged from follow-up data: TP53 and BRCA1 LOH were associated with a shorter relapse free interval (RFI) (p = 0.03) and a poorer overall survival (OS) (p = 0.04), respectively. This study underlines different biological profiles in the two age groups investigated, probably reflecting different mechanisms of carcinogenesis. In accordance with adverse histopathological features in early-onset patients, LOH-related cancers have an unfavorable prognosis.
63 schema:genre research_article
64 schema:inLanguage en
65 schema:isAccessibleForFree false
66 schema:isPartOf Nbba27ef4f3cb4385ae862e878c7a08ea
67 Ned0468f96c17486e87683f7f05d8d2ed
68 sg:journal.1092777
69 schema:name Biophenotypes and survival of BRCA1 and TP53 deleted breast cancer in young women
70 schema:pagination 135-142
71 schema:productId N6d68a46c72804c2a89c0785a8e1c89ac
72 N99bb9102e85c4cc891130933ab22abe1
73 Na933bfead31946aa84758e5684acf574
74 Neb01247ac11046f98cd62b5e051857b5
75 Nf959c3b1fba04a3da1852a8dad61d19c
76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044881763
77 https://doi.org/10.1023/a:1010643515095
78 schema:sdDatePublished 2019-04-10T19:06
79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
80 schema:sdPublisher N757ab7edd3334b108090b9aa902d96e6
81 schema:url http://link.springer.com/10.1023/A:1010643515095
82 sgo:license sg:explorer/license/
83 sgo:sdDataset articles
84 rdf:type schema:ScholarlyArticle
85 N01670a2ccf0d4f4fae670eb785ddd116 rdf:first sg:person.01027055113.91
86 rdf:rest Nb4de9f0ab01743b581167dd8603d4439
87 N02abdd85940a41eaa5533d846e49d3c1 rdf:first sg:person.015013022320.73
88 rdf:rest N08a5aeb463d2434bab9c5d36cebeee0c
89 N08a5aeb463d2434bab9c5d36cebeee0c rdf:first sg:person.01356425051.97
90 rdf:rest N5e090b13ed9a46f387a014acd5446b37
91 N0d9af7173ae14f8f9c74e8f00af841b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Breast Neoplasms
93 rdf:type schema:DefinedTerm
94 N15dc11aaf1044d3cb33c4b42ff74c834 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Carcinoma, Ductal, Breast
96 rdf:type schema:DefinedTerm
97 N37b231b7ae2c41a9a3836481b05ee57f rdf:first sg:person.01151636651.28
98 rdf:rest rdf:nil
99 N3819a0d7ed36491da245d472c4c9764c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Humans
101 rdf:type schema:DefinedTerm
102 N4b2924d620344b2bbfb0055eae3363f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Immunohistochemistry
104 rdf:type schema:DefinedTerm
105 N5e090b13ed9a46f387a014acd5446b37 rdf:first Na8555401357b459e97ea0d504c68bcaa
106 rdf:rest N9daff43405324666811b584c2dd667bf
107 N691a2d56782a4e4bb327cd2d8168b958 rdf:first sg:person.01026557025.44
108 rdf:rest Neb9eb1bd6f5249cf990ea86f53af076d
109 N6d68a46c72804c2a89c0785a8e1c89ac schema:name readcube_id
110 schema:value d5c8e27349fc85c10996b080d6ee5abc4ccec2fb73d3d2c367e14ac852846248
111 rdf:type schema:PropertyValue
112 N757ab7edd3334b108090b9aa902d96e6 schema:name Springer Nature - SN SciGraph project
113 rdf:type schema:Organization
114 N99bb9102e85c4cc891130933ab22abe1 schema:name dimensions_id
115 schema:value pub.1044881763
116 rdf:type schema:PropertyValue
117 N9daff43405324666811b584c2dd667bf rdf:first sg:person.01336457446.57
118 rdf:rest N691a2d56782a4e4bb327cd2d8168b958
119 N9e056ec1e7894991bf3af6bc24675605 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Survival Analysis
121 rdf:type schema:DefinedTerm
122 Na40e79e52f8f473298f94dedd68f7a8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Loss of Heterozygosity
124 rdf:type schema:DefinedTerm
125 Na8555401357b459e97ea0d504c68bcaa schema:affiliation Nbb34e5e08fb84a268f3be9e43d3cf134
126 schema:familyName Cariello
127 schema:givenName Anna
128 rdf:type schema:Person
129 Na933bfead31946aa84758e5684acf574 schema:name doi
130 schema:value 10.1023/a:1010643515095
131 rdf:type schema:PropertyValue
132 Nab5fca82062f4e3a86f052a16dfd8b4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Genes, BRCA1
134 rdf:type schema:DefinedTerm
135 Nacfe3e094026463d89bfa39cac99ee7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Carcinoma, Lobular
137 rdf:type schema:DefinedTerm
138 Nb3a54a7a9e934168904c7063896ef677 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Adult
140 rdf:type schema:DefinedTerm
141 Nb4de9f0ab01743b581167dd8603d4439 rdf:first sg:person.0651263412.59
142 rdf:rest N02abdd85940a41eaa5533d846e49d3c1
143 Nbb34e5e08fb84a268f3be9e43d3cf134 schema:name Division of Oncology, ‘S. Maria delle Grazie’ Hospital, Ravenna, Italy
144 rdf:type schema:Organization
145 Nbba27ef4f3cb4385ae862e878c7a08ea schema:issueNumber 2
146 rdf:type schema:PublicationIssue
147 Nc73e2b7c942c43d0940a9d5c4be3b4de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Female
149 rdf:type schema:DefinedTerm
150 Nc85db537683a416bb40babafffb8c6ef rdf:first sg:person.01117275052.75
151 rdf:rest N01670a2ccf0d4f4fae670eb785ddd116
152 Nd50fc771d68641dbaecc934939f3ec0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Polymerase Chain Reaction
154 rdf:type schema:DefinedTerm
155 Ne11ddf3a1769445586b2652ab944938a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Genes, p53
157 rdf:type schema:DefinedTerm
158 Neb01247ac11046f98cd62b5e051857b5 schema:name nlm_unique_id
159 schema:value 8111104
160 rdf:type schema:PropertyValue
161 Neb9eb1bd6f5249cf990ea86f53af076d rdf:first sg:person.0652524225.41
162 rdf:rest N37b231b7ae2c41a9a3836481b05ee57f
163 Ned0468f96c17486e87683f7f05d8d2ed schema:volumeNumber 66
164 rdf:type schema:PublicationVolume
165 Nf3265ae7bdaa424bad56a516a9f0e395 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Italy
167 rdf:type schema:DefinedTerm
168 Nf959c3b1fba04a3da1852a8dad61d19c schema:name pubmed_id
169 schema:value 11437099
170 rdf:type schema:PropertyValue
171 Nfa3c2faf55484af58cb4b0217b603336 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Phenotype
173 rdf:type schema:DefinedTerm
174 Nfba5504944774565a0a74e79783c4ba3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Middle Aged
176 rdf:type schema:DefinedTerm
177 Nfe3fb46026a4466f9ed07341c2c6b029 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Age Factors
179 rdf:type schema:DefinedTerm
180 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
181 schema:name Medical and Health Sciences
182 rdf:type schema:DefinedTerm
183 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
184 schema:name Oncology and Carcinogenesis
185 rdf:type schema:DefinedTerm
186 sg:journal.1092777 schema:issn 0167-6806
187 1573-7217
188 schema:name Breast Cancer Research and Treatment
189 rdf:type schema:Periodical
190 sg:person.01026557025.44 schema:affiliation https://www.grid.ac/institutes/grid.8484.0
191 schema:familyName Matteuzzi
192 schema:givenName Maurizio
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026557025.44
194 rdf:type schema:Person
195 sg:person.01027055113.91 schema:affiliation https://www.grid.ac/institutes/grid.8484.0
196 schema:familyName Albonico
197 schema:givenName Giuseppe
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027055113.91
199 rdf:type schema:Person
200 sg:person.01117275052.75 schema:affiliation https://www.grid.ac/institutes/grid.8484.0
201 schema:familyName Querzoli
202 schema:givenName Patrizia
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117275052.75
204 rdf:type schema:Person
205 sg:person.01151636651.28 schema:affiliation https://www.grid.ac/institutes/grid.8484.0
206 schema:familyName Nenci
207 schema:givenName Italo
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151636651.28
209 rdf:type schema:Person
210 sg:person.01336457446.57 schema:affiliation https://www.grid.ac/institutes/grid.8484.0
211 schema:familyName Pedriali
212 schema:givenName Massimo
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336457446.57
214 rdf:type schema:Person
215 sg:person.01356425051.97 schema:affiliation https://www.grid.ac/institutes/grid.8484.0
216 schema:familyName Rinaldi
217 schema:givenName Rosa
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356425051.97
219 rdf:type schema:Person
220 sg:person.015013022320.73 schema:affiliation https://www.grid.ac/institutes/grid.8484.0
221 schema:familyName Ferretti
222 schema:givenName Stefano
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015013022320.73
224 rdf:type schema:Person
225 sg:person.0651263412.59 schema:affiliation https://www.grid.ac/institutes/grid.8484.0
226 schema:familyName Iasio
227 schema:givenName Maria Grazia di
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651263412.59
229 rdf:type schema:Person
230 sg:person.0652524225.41 schema:affiliation https://www.grid.ac/institutes/grid.8484.0
231 schema:familyName Maestri
232 schema:givenName Iva
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652524225.41
234 rdf:type schema:Person
235 sg:pub.10.1007/bf00666204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022493002
236 https://doi.org/10.1007/bf00666204
237 rdf:type schema:CreativeWork
238 sg:pub.10.1007/bf00666584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016575262
239 https://doi.org/10.1007/bf00666584
240 rdf:type schema:CreativeWork
241 sg:pub.10.1023/a:1005853022804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013801113
242 https://doi.org/10.1023/a:1005853022804
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/bjc.1989.137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023936240
245 https://doi.org/10.1038/bjc.1989.137
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/bjc.1993.236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033771512
248 https://doi.org/10.1038/bjc.1993.236
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/bjc.1996.632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037629099
251 https://doi.org/10.1038/bjc.1996.632
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/bjc.1997.223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001925195
254 https://doi.org/10.1038/bjc.1997.223
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/ng0495-444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018646090
257 https://doi.org/10.1038/ng0495-444
258 rdf:type schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1074361782 schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1074549511 schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1082602599 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1083084088 schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1083187481 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1083347103 schema:CreativeWork
265 https://doi.org/10.1002/(sici)1096-9896(199605)179:1<121::aid-path536>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1039476485
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/(sici)1097-0142(19960101)77:1<97::aid-cncr16>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034491633
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/(sici)1097-0142(19960215)77:4<697::aid-cncr16>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1016399570
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1002/(sici)1097-0142(19980701)83:1<89::aid-cncr12>3.0.co;2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014443597
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1002/(sici)1097-0142(20000315)88:6<1393::aid-cncr17>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1052099187
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1002/(sici)1097-0215(19970807)72:4<599::aid-ijc8>3.0.co;2-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1019043939
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1002/(sici)1098-2264(199703)18:3<181::aid-gcc5>3.0.co;2-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1003967676
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1002/1097-0142(19951215)76:12<2510::aid-cncr2820761216>3.0.co;2-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1010970205
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/0010-468x(72)90019-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017943682
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/0046-8177(93)90157-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1046207125
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/0140-6736(93)92407-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1009213834
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/0959-8049(95)00399-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026047657
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/s0140-6736(05)64441-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017978835
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/s0140-6736(05)79248-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045644349
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/s0140-6736(97)07065-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036503442
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s0168-9525(99)01930-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022328573
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1023/a:1008340723974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056303291
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1046/j.1365-2559.1999.00619.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025224829
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1101/gr.6.11.1029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032748231
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1111/j.1365-2559.1991.tb00229.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010222506
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1111/j.1699-0463.1997.tb00550.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035358434
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1126/science.2270482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062529993
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1126/science.7545954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041365117
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1136/mp.51.5.237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027236776
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1177/106689699600400206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037563821
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1200/jco.1998.16.5.1642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083260934
316 rdf:type schema:CreativeWork
317 https://www.grid.ac/institutes/grid.8484.0 schema:alternateName University of Ferrara
318 schema:name Department of Experimental and Diagnostic Medicine, Section of Morbid Anatomy, Histopathology and Cytopathology, Ferrara University, Ferrara, Italy
319 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...