Controlled Dissolution of Phenytoin by Hybridizing with Silica Nanoparticles View Full Text


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Article Info

DATE

1999-06

AUTHORS

H. Goto, T. Isobe, M. Senna

ABSTRACT

A sparingly soluble model drug, phenytoin (5,5-diphenyl-hydantoin, denoted as PT), was incorporated during or after hydrolysis and polycondensation of tetra orthoethyl silicate (TEOS) to obtain silica–drug hybrids. We also compare the hybrids obtained by sol–gel process with those obtained by simple adsorption on nonporous silica particles. The initial rate of dissolution in water increases by a factor of 40 with respect to the intact PT by aging silica before drug addition. The IR results show that νC=O in the position 2 of PT and νN–H shift toward the higher wavenumber, showing that intermolecular hydrogen bonds between C=O and N–H are loosened or broken to form new hydrogen bonds between C=O in PT and Si–OH in silica. The dissolution rate of PT is determined by the degree of the breakage of hydrogen bonds between PT molecules and the intensity of the interaction between silica and PT. More... »

PAGES

205-213

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1010048332458

DOI

http://dx.doi.org/10.1023/a:1010048332458

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033227157


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