Structure and Function of Immunoglobulins View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-11

AUTHORS

Peter J. Späth

ABSTRACT

Efficient elimination of pathogens form the host's body needs the cooperation of recognition/receptor molecules of adaptive and innate immunity. Receptors of innate immunity are germline gene encoded and fixed to recognize a limited number of structures only. Structures on pathogens however are very diverse and they can undergo changes due to selection pressure. Recognition molecules of adaptive immunity, the immunoglobulin molecules, can be recognized as biochemical transducers which reduce the diversity of antigenic epitopes of microbes to a few principal structures. These principal structures are such that recognition/receptor molecules of innate immunity can cope with: complement can be activated efficiently and receptors of the reticuloendothelial system (RES) can ensure ultimate elimination of pathogens, their debris and their metabolic products. The structure of immunoglobulins perfectly fits their transducer function: the bipolar molecules have variable regions for recognition of diversity of antigenic epitopes and have a few different constant regions which mediate effector functions. The first part of this review focus on the transducer function in host defense of high-affinity, narrowly tuned and in elimination of senescent and altered self of low-affinity cross-reactive immunoglobulins. In a second part the review gives a an outlook on how recognition by immunoglobulins of host's structures may help to attenuate overshooting inflammation (cytokines, complement) and tissue destruction by inappropriate complement activation. Finally immunoglobulin preparations which have been used in clinic will be mentioned briefly. These have helped considerably to understand immunoglobulin function in humans. More... »

PAGES

197-218

Journal

TITLE

Sepsis

ISSUE

3

VOLUME

3

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1009899803032

DOI

http://dx.doi.org/10.1023/a:1009899803032

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040660432


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N-Triples is a line-based linked data format ideal for batch operations.

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