Phosphatidylinositol 3′ Kinase Signaling in Mammary Tumorigenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-01

AUTHORS

Michael P. Scheid, James R. Woodgett

ABSTRACT

Suppression of apoptosis is now recognized as a key contributory element to tumorigenesis in animal models and human cancer. The phosphatidylinositol 3′ kinase pathway plays a seminal role in cell death suppression or “survival signaling.” Over the past 5 years, the molecular mechanisms by which this pathway exerts its death suppressive effects have slowly been revealed. This review summarizes the players involved, their importance in human cancer and their specific involvement in breast cancer. More... »

PAGES

83-99

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  • Identifiers

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    http://scigraph.springernature.com/pub.10.1023/a:1009520616247

    DOI

    http://dx.doi.org/10.1023/a:1009520616247

    DIMENSIONS

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    https://www.ncbi.nlm.nih.gov/pubmed/11467455


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