Tubular morphogenesis by genotoxic therapeutic agents that induce NF-κB activation in humanvascular endothelial cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-12

AUTHORS

Daisuke Goto, Hiroto Izumi, Mayumi Ono, Takeshi Okamoto, Kimitoshi Kohno, Michihiko Kuwano

ABSTRACT

Angiogenic stimuli induce tubular morphogenesis and angiogenesis in vascular endothelial cells, but these cells are highly vulnerable to cytokines, oxidative stress, and genotoxic anticancer agents. A transcription factor, NF-κB, is involved in the protection against apoptosis and in angiogenesis in response to stimuli that could induce cell death. NF-κB was specifically activated by the genotoxic anticancer therapeutic agents etoposide and doxorubicin, but not by bleomycin, mitomycin C and cisplatin, in human vascular endothelial cells in three independent assay systems: nuclear translocation of NF-κB, binding of NF-κB to its consensus sequence, and NF-κB -dependent transcription. Exposure to etoposide and doxorubicin induced tubular morphogenesis by vascular endothelial cells in type I collagen gel at rates comparable to tumor necrosis factor-α. Co-administration of NF-κB antisense oligonucleotides inhibited the angiogenesis by doxorubicin and etoposide. In contrast, bleomycin, mitomycin C, and cisplatin did not induce angiogenesis. An angiogenic factor, interleukin 8, was dramatically induced in vascular endothelial cells treated with doxorubicin, but not in cells treated with cisplatin. Co-administration of anti-interleukin 8 antibody almost completely blocked the doxorubicin-induced angiogenesis in vitro, suggesting a paracrine/autocrine control through drug-induced angiogenic factor(s). The presence or absence of NF-κB activation may have an essential role in tubular morphogenesis by vascular endothelial cells during chemotherapeutic treatment, possibly through interleukin 8. More... »

PAGES

345-356

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1009252811114

DOI

http://dx.doi.org/10.1023/a:1009252811114

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051493338

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14517454


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry, Kyushu University School of Medicine, 812-82, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Biochemistry, Kyushu University School of Medicine, 812-82, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goto", 
        "givenName": "Daisuke", 
        "id": "sg:person.0736567550.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736567550.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry, Kyushu University School of Medicine, 812-82, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Biochemistry, Kyushu University School of Medicine, 812-82, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Izumi", 
        "givenName": "Hiroto", 
        "id": "sg:person.01007122017.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007122017.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry, Kyushu University School of Medicine, 812-82, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Biochemistry, Kyushu University School of Medicine, 812-82, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ono", 
        "givenName": "Mayumi", 
        "id": "sg:person.013120526702.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013120526702.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Genetics, Nagoya City University Medical School, 467, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Department of Molecular Genetics, Nagoya City University Medical School, 467, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okamoto", 
        "givenName": "Takeshi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, University of Occupational Environmental Health, 807, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Molecular Biology, University of Occupational Environmental Health, 807, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kohno", 
        "givenName": "Kimitoshi", 
        "id": "sg:person.0745037146.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745037146.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry, Kyushu University School of Medicine, 812-82, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Biochemistry, Kyushu University School of Medicine, 812-82, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuwano", 
        "givenName": "Michihiko", 
        "id": "sg:person.0615256535.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615256535.33"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/384273a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009210140", 
          "https://doi.org/10.1038/384273a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0695-525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032645131", 
          "https://doi.org/10.1038/nm0695-525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/381713a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028535114", 
          "https://doi.org/10.1038/381713a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/374811a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033403606", 
          "https://doi.org/10.1038/374811a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-12", 
    "datePublishedReg": "1998-12-01", 
    "description": "Angiogenic stimuli induce tubular morphogenesis and angiogenesis in vascular endothelial cells, but these cells are highly vulnerable to cytokines, oxidative stress, and genotoxic anticancer agents. A transcription factor, NF-\u03baB, is involved in the protection against apoptosis and in angiogenesis in response to stimuli that could induce cell death. NF-\u03baB was specifically activated by the genotoxic anticancer therapeutic agents etoposide and doxorubicin, but not by bleomycin, mitomycin C and cisplatin, in human vascular endothelial cells in three independent assay systems: nuclear translocation of NF-\u03baB, binding of NF-\u03baB to its consensus sequence, and NF-\u03baB -dependent transcription. Exposure to etoposide and doxorubicin induced tubular morphogenesis by vascular endothelial cells in type I collagen gel at rates comparable to tumor necrosis factor-\u03b1. Co-administration of NF-\u03baB antisense oligonucleotides inhibited the angiogenesis by doxorubicin and etoposide. In contrast, bleomycin, mitomycin C, and cisplatin did not induce angiogenesis. An angiogenic factor, interleukin 8, was dramatically induced in vascular endothelial cells treated with doxorubicin, but not in cells treated with cisplatin. Co-administration of anti-interleukin 8 antibody almost completely blocked the doxorubicin-induced angiogenesis in vitro, suggesting a paracrine/autocrine control through drug-induced angiogenic factor(s). The presence or absence of NF-\u03baB activation may have an essential role in tubular morphogenesis by vascular endothelial cells during chemotherapeutic treatment, possibly through interleukin 8.", 
    "genre": "article", 
    "id": "sg:pub.10.1023/a:1009252811114", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1119026", 
        "issn": [
          "0969-6970", 
          "1573-7209"
        ], 
        "name": "Angiogenesis", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "keywords": [
      "vascular endothelial cells", 
      "NF-\u03baB activation", 
      "NF-\u03baB", 
      "endothelial cells", 
      "interleukin-8", 
      "paracrine/autocrine control", 
      "therapeutic agents", 
      "mitomycin C", 
      "tumor necrosis factor", 
      "human vascular endothelial cells", 
      "NF-\u03baB-dependent transcription", 
      "necrosis factor", 
      "angiogenic factors", 
      "autocrine control", 
      "chemotherapeutic treatment", 
      "tubular morphogenesis", 
      "anticancer therapeutic agents", 
      "oxidative stress", 
      "angiogenic stimuli", 
      "angiogenesis", 
      "nuclear translocation", 
      "cisplatin", 
      "doxorubicin", 
      "anticancer agents", 
      "cell death", 
      "bleomycin", 
      "type I", 
      "cells", 
      "activation", 
      "agents", 
      "stimuli", 
      "cytokines", 
      "transcription factors", 
      "factors", 
      "etoposide", 
      "antibodies", 
      "essential role", 
      "death", 
      "treatment", 
      "apoptosis", 
      "exposure", 
      "antisense", 
      "response", 
      "translocation", 
      "morphogenesis", 
      "absence", 
      "control", 
      "role", 
      "rate", 
      "binding", 
      "contrast", 
      "consensus sequence", 
      "transcription", 
      "presence", 
      "protection", 
      "stress", 
      "gel", 
      "sequence", 
      "system"
    ], 
    "name": "Tubular morphogenesis by genotoxic therapeutic agents that induce NF-\u03baB activation in humanvascular endothelial cells", 
    "pagination": "345-356", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051493338"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1009252811114"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "14517454"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1009252811114", 
      "https://app.dimensions.ai/details/publication/pub.1051493338"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_263.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1023/a:1009252811114"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1009252811114'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1009252811114'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1009252811114'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1009252811114'


 

This table displays all metadata directly associated to this object as RDF triples.

180 TRIPLES      21 PREDICATES      90 URIs      77 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1009252811114 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 anzsrc-for:1115
4 schema:author N3444553181c645c78de97d8a73ebd575
5 schema:citation sg:pub.10.1038/374811a0
6 sg:pub.10.1038/381713a0
7 sg:pub.10.1038/384273a0
8 sg:pub.10.1038/nm0695-525
9 schema:datePublished 1998-12
10 schema:datePublishedReg 1998-12-01
11 schema:description Angiogenic stimuli induce tubular morphogenesis and angiogenesis in vascular endothelial cells, but these cells are highly vulnerable to cytokines, oxidative stress, and genotoxic anticancer agents. A transcription factor, NF-κB, is involved in the protection against apoptosis and in angiogenesis in response to stimuli that could induce cell death. NF-κB was specifically activated by the genotoxic anticancer therapeutic agents etoposide and doxorubicin, but not by bleomycin, mitomycin C and cisplatin, in human vascular endothelial cells in three independent assay systems: nuclear translocation of NF-κB, binding of NF-κB to its consensus sequence, and NF-κB -dependent transcription. Exposure to etoposide and doxorubicin induced tubular morphogenesis by vascular endothelial cells in type I collagen gel at rates comparable to tumor necrosis factor-α. Co-administration of NF-κB antisense oligonucleotides inhibited the angiogenesis by doxorubicin and etoposide. In contrast, bleomycin, mitomycin C, and cisplatin did not induce angiogenesis. An angiogenic factor, interleukin 8, was dramatically induced in vascular endothelial cells treated with doxorubicin, but not in cells treated with cisplatin. Co-administration of anti-interleukin 8 antibody almost completely blocked the doxorubicin-induced angiogenesis in vitro, suggesting a paracrine/autocrine control through drug-induced angiogenic factor(s). The presence or absence of NF-κB activation may have an essential role in tubular morphogenesis by vascular endothelial cells during chemotherapeutic treatment, possibly through interleukin 8.
12 schema:genre article
13 schema:isAccessibleForFree false
14 schema:isPartOf N41ded8e07d4e46fbb6b12148435c4a80
15 Nd462a793e77042b9a19c35c2499c477e
16 sg:journal.1119026
17 schema:keywords NF-κB
18 NF-κB activation
19 NF-κB-dependent transcription
20 absence
21 activation
22 agents
23 angiogenesis
24 angiogenic factors
25 angiogenic stimuli
26 antibodies
27 anticancer agents
28 anticancer therapeutic agents
29 antisense
30 apoptosis
31 autocrine control
32 binding
33 bleomycin
34 cell death
35 cells
36 chemotherapeutic treatment
37 cisplatin
38 consensus sequence
39 contrast
40 control
41 cytokines
42 death
43 doxorubicin
44 endothelial cells
45 essential role
46 etoposide
47 exposure
48 factors
49 gel
50 human vascular endothelial cells
51 interleukin-8
52 mitomycin C
53 morphogenesis
54 necrosis factor
55 nuclear translocation
56 oxidative stress
57 paracrine/autocrine control
58 presence
59 protection
60 rate
61 response
62 role
63 sequence
64 stimuli
65 stress
66 system
67 therapeutic agents
68 transcription
69 transcription factors
70 translocation
71 treatment
72 tubular morphogenesis
73 tumor necrosis factor
74 type I
75 vascular endothelial cells
76 schema:name Tubular morphogenesis by genotoxic therapeutic agents that induce NF-κB activation in humanvascular endothelial cells
77 schema:pagination 345-356
78 schema:productId N3744325917ee4b2b9330a52ccc7bf4a0
79 N7983d7c54b3d47d5bd5e9c4c07b7db1d
80 Naab69c67ba9e460e8e66c364172d47bf
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051493338
82 https://doi.org/10.1023/a:1009252811114
83 schema:sdDatePublished 2022-09-02T15:48
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher N8c8a987ed63d4793ba7873e837a43feb
86 schema:url https://doi.org/10.1023/a:1009252811114
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N114ff8673f184eab82a34df8c1488ec8 rdf:first sg:person.013120526702.99
91 rdf:rest N8509c754dfae4ee480b10f10856cc334
92 N3444553181c645c78de97d8a73ebd575 rdf:first sg:person.0736567550.52
93 rdf:rest Na80645c74b5447b19642d45cb432b048
94 N3744325917ee4b2b9330a52ccc7bf4a0 schema:name doi
95 schema:value 10.1023/a:1009252811114
96 rdf:type schema:PropertyValue
97 N41ded8e07d4e46fbb6b12148435c4a80 schema:volumeNumber 2
98 rdf:type schema:PublicationVolume
99 N57a3c06b8ecf412eb223dacda32acbd9 rdf:first sg:person.0745037146.34
100 rdf:rest N99747287abc84079bc06a5c65fe56170
101 N7983d7c54b3d47d5bd5e9c4c07b7db1d schema:name dimensions_id
102 schema:value pub.1051493338
103 rdf:type schema:PropertyValue
104 N7f7e1d43be22405392f6d958f99ef642 schema:affiliation grid-institutes:grid.260433.0
105 schema:familyName Okamoto
106 schema:givenName Takeshi
107 rdf:type schema:Person
108 N8509c754dfae4ee480b10f10856cc334 rdf:first N7f7e1d43be22405392f6d958f99ef642
109 rdf:rest N57a3c06b8ecf412eb223dacda32acbd9
110 N8c8a987ed63d4793ba7873e837a43feb schema:name Springer Nature - SN SciGraph project
111 rdf:type schema:Organization
112 N99747287abc84079bc06a5c65fe56170 rdf:first sg:person.0615256535.33
113 rdf:rest rdf:nil
114 Na80645c74b5447b19642d45cb432b048 rdf:first sg:person.01007122017.64
115 rdf:rest N114ff8673f184eab82a34df8c1488ec8
116 Naab69c67ba9e460e8e66c364172d47bf schema:name pubmed_id
117 schema:value 14517454
118 rdf:type schema:PropertyValue
119 Nd462a793e77042b9a19c35c2499c477e schema:issueNumber 4
120 rdf:type schema:PublicationIssue
121 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
122 schema:name Medical and Health Sciences
123 rdf:type schema:DefinedTerm
124 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
125 schema:name Clinical Sciences
126 rdf:type schema:DefinedTerm
127 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
128 schema:name Pharmacology and Pharmaceutical Sciences
129 rdf:type schema:DefinedTerm
130 sg:journal.1119026 schema:issn 0969-6970
131 1573-7209
132 schema:name Angiogenesis
133 schema:publisher Springer Nature
134 rdf:type schema:Periodical
135 sg:person.01007122017.64 schema:affiliation grid-institutes:grid.177174.3
136 schema:familyName Izumi
137 schema:givenName Hiroto
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007122017.64
139 rdf:type schema:Person
140 sg:person.013120526702.99 schema:affiliation grid-institutes:grid.177174.3
141 schema:familyName Ono
142 schema:givenName Mayumi
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013120526702.99
144 rdf:type schema:Person
145 sg:person.0615256535.33 schema:affiliation grid-institutes:grid.177174.3
146 schema:familyName Kuwano
147 schema:givenName Michihiko
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615256535.33
149 rdf:type schema:Person
150 sg:person.0736567550.52 schema:affiliation grid-institutes:grid.177174.3
151 schema:familyName Goto
152 schema:givenName Daisuke
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736567550.52
154 rdf:type schema:Person
155 sg:person.0745037146.34 schema:affiliation grid-institutes:grid.271052.3
156 schema:familyName Kohno
157 schema:givenName Kimitoshi
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745037146.34
159 rdf:type schema:Person
160 sg:pub.10.1038/374811a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033403606
161 https://doi.org/10.1038/374811a0
162 rdf:type schema:CreativeWork
163 sg:pub.10.1038/381713a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028535114
164 https://doi.org/10.1038/381713a0
165 rdf:type schema:CreativeWork
166 sg:pub.10.1038/384273a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009210140
167 https://doi.org/10.1038/384273a0
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/nm0695-525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032645131
170 https://doi.org/10.1038/nm0695-525
171 rdf:type schema:CreativeWork
172 grid-institutes:grid.177174.3 schema:alternateName Department of Biochemistry, Kyushu University School of Medicine, 812-82, Fukuoka, Japan
173 schema:name Department of Biochemistry, Kyushu University School of Medicine, 812-82, Fukuoka, Japan
174 rdf:type schema:Organization
175 grid-institutes:grid.260433.0 schema:alternateName Department of Molecular Genetics, Nagoya City University Medical School, 467, Nagoya, Japan
176 schema:name Department of Molecular Genetics, Nagoya City University Medical School, 467, Nagoya, Japan
177 rdf:type schema:Organization
178 grid-institutes:grid.271052.3 schema:alternateName Department of Molecular Biology, University of Occupational Environmental Health, 807, Kitakyushu, Japan
179 schema:name Department of Molecular Biology, University of Occupational Environmental Health, 807, Kitakyushu, Japan
180 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...