Transcripts of the MHM region on the chicken Z chromosome accumulate as non-coding RNA in the nucleus of female cells ... View Full Text


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Article Info

DATE

2001-02

AUTHORS

Mika Teranishi, Yukiko Shimada, Tetsuya Hori, Osamu Nakabayashi, Tateki Kikuchi, Tracy Macleod, Robert Pym, Bruce Sheldon, Irina Solovei, Herbert Macgregor, Shigeki Mizuno

ABSTRACT

The male hypermethylated (MHM) region, located near the middle of the short arm of the Z chromosome of chickens, consists of approximately 210 tandem repeats of a BamHI 2.2-kb sequence unit. Cytosines of the CpG dinucleotides of this region are extensively methylated on the two Z chromosomes in the male but much less methylated on the single Z chromosome in the female. The state of methylation of the MHM region is established after fertilization by about the 1-day embryonic stage. The MHM region is transcribed only in the female from the particular strand into heterogeneous, high molecular-mass, non-coding RNA, which is accumulated at the site of transcription, adjacent to the DMRT1 locus, in the nucleus. The transcriptional silence of the MHM region in the male is most likely caused by the CpG methylation, since treatment of the male embryonic fibroblasts with 5-azacytidine results in hypo-methylation and active transcription of this region. In ZZW triploid chickens, MHM regions are hypomethylated and transcribed on the two Z chromosomes, whereas MHM regions are hypermethylated and transcriptionally inactive on the three Z chromosomes in ZZZ triploid chickens, suggesting a possible role of the W chromosome on the state of the MHM region. More... »

PAGES

147-165

References to SciGraph publications

  • 1990-07. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes in NATURE
  • 1992-06. Distribution of XhoI and EcoRI family repetitive DNA sequences into separate domains in the chicken W chromosome in CHROMOSOMA
  • 1993-09. Avian sex chromosomes in the lampbrush form: the ZW lampbrush bivalents from six species of bird in CHROMOSOME RESEARCH
  • 1991-01. A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome in NATURE
  • 1993-11. Identification and localization of two genes on the chicken Z chromosome: implication of evolutionary conservation of the Z chromosome among avian species in CHROMOSOME RESEARCH
  • 1997-02. Molecular characterization and cytological mapping of a non-repetitive DNA sequence region from the W chromosome of chicken and its use as a universal probe for sexing Carinatae birds in CHROMOSOME RESEARCH
  • 1998-02-12. Evidence for evolutionary conservation of sex-determining genes in NATURE
  • 2000-04. ASW: a gene with conserved avian W-linkage and female specific expression in chick embryonic gonad in DEVELOPMENT GENES AND EVOLUTION
  • 1999-04. Tsix, a gene antisense to Xist at the X-inactivation centre in NATURE GENETICS
  • 1987-12. Nucleotide sequences and unusual electrophoretic behavior of the W chromosome-specific repeating DNA units of the domestic fowl, Gallus gallus domesticus in CHROMOSOMA
  • 1990-07. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif in NATURE
  • 1998-06. Specific Chromomeres on the Chicken W Lampbrush Chromosome Contain Specific Repetitive DNA Sequence Families in CHROMOSOME RESEARCH
  • 1999-03. 300 million years of conserved synteny between chicken Z and human chromosome 9 in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1023/a:1009235120741

    DOI

    http://dx.doi.org/10.1023/a:1009235120741

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048918377

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11321370


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