β-Chitin-based wound dressing containing silver sulfurdiazine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-12

AUTHORS

Young Moo Lee, Seong Soo Kim, Moon Hyang Park, Kang Won Song, Yong Kiel Sung, In Kyu Kang

ABSTRACT

Physical and biological properties of some wound dressing materials based on beta-chitin were studied. Water vapor transmission rates (WVTR), oxygen permeabilities and biodegradation kinetics were examined for film-type samples. WVTR of samples was in the range 2400-2800 g/m2/day. However, oxygen permeabilities of the samples were relatively low. To improve oxygen permeabilities, porous sponge-type wound dressing materials were prepared. In addition, these sponge-type samples contained antimicrobial agents, silver sulfadiazine (AgSD), in order to prevent bacteria infection on a wound surface. Anti-microbacterial tests on agar plate were carried out to confirm the bactericidal capacity of present materials. These materials impregnating AgSD had the complete bactericidal capacity against pseudomonas aeruginosa up to 7 days. Finally, a wound healing effect of beta-chitin-based semi-interpenetrating polymer networks was evaluated from the animal test using the wistar rat in vivo. Histological studies confirm the proliferation of fibroblasts in the wound bed and a distinct reduction in infectious cells. More... »

PAGES

817-823

References to SciGraph publications

  • 1994-04. Physical characterization of a new biomaterial for wound management in JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1023/a:1008961730929

    DOI

    http://dx.doi.org/10.1023/a:1008961730929

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036063502

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15348066


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