Circulating levels of sex hormones and their relation to risk factors for breast cancer: a cross-sectional study in 1092 pre- ... View Full Text


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Article Info

DATE

2001-01

AUTHORS

Pia K. Verkasalo, Hollie V. Thomas, Paul N. Appleby, Gwyneth K. Davey, Timothy J. Key

ABSTRACT

Objective: To investigate the relationships between plasma concentrations of sex hormones and risk factors for breast cancer.Methods: We investigated the relationship of plasma concentrations of estradiol, progesterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and sex hormone-binding globulin (SHBG) with breast cancer risk factors in 636 premenopausal and 456 postmenopausal women. Risk factor data were obtained from questionnaires and hormone concentrations measured by immunoassays; variations in geometric means were compared using analysis of covariance.Results: SHBG decreased with increasing body mass index and increasing waist–hip ratio both in pre- and postmenopausal women. In postmenopausal women only, estradiol increased with increasing body mass index. In premenopausal women, estradiol decreased with increasing physical activity, estradiol was higher in current than in ex- and non-smokers, and FSH decreased with increasing alcohol intake. No associations were observed between sex hormones and age at menarche, parity, age at menopause, and previous use of oral contraceptives in either pre- or postmenopausal women.Conclusions: Certain factors such as obesity and perhaps waist–hip ratio, physical activity and alcohol consumption, but probably not age at menarche and parity, may mediate their effects on breast cancer risk by changing circulating concentrations of sex hormones. More... »

PAGES

47-59

References to SciGraph publications

  • 1999-06-11. Oestradiol and sex hormone-binding globulin in premenopausal and post-menopausal meat-eaters, vegetarians and vegans in BRITISH JOURNAL OF CANCER
  • 1987-06. The effects of moderate physical activity on menstrual cycle patterns in adolescence: Implications for breast cancer prevention in BRITISH JOURNAL OF CANCER
  • 1987-11. Sex hormone binding globulin and risk factors for breast cancer in a population of normal women who had never used exogenous sex hormones in BRITISH JOURNAL OF CANCER
  • 1990-02. Oestrogen binding and risk factors for breast cancer in BRITISH JOURNAL OF CANCER
  • 1994-01. Alcoholic beverage consumption in relation to risk of breast cancer: meta-analysis and review in CANCER CAUSES & CONTROL
  • 1991-07. Age at menarche and estrogen concentrations of adult women in CANCER CAUSES & CONTROL
  • 1982-03. Differentiation of the mammary gland and susceptibility to carcinogenesis in BREAST CANCER RESEARCH AND TREATMENT
  • 1981-06. Elevated levels of prolactin in nulliparous women in BRITISH JOURNAL OF CANCER
  • 1994-01. The relation of reported alcohol ingestion to plasma levels of estrogens and androgens in premenopausal women (Maryland, United States) in CANCER CAUSES & CONTROL
  • 1991-05. Blood concentrations of estradiol and sex hormone-binding globulin in relation to age at menarche in premenopausal British and Japanese women in BREAST CANCER RESEARCH AND TREATMENT
  • 1995-05. Reproductive factors and family history of breast cancer in relation to plasma estrogen and prolactin levels in postmenopausal women in the Nurses' Health Study (United States) in CANCER CAUSES & CONTROL
  • 1998-03. Serum hormone levels in relation to reproductive and lifestyle factors in postmenopausal women (United States) in CANCER CAUSES & CONTROL
  • 1999-12-01. Endogenous hormones and the aetiology of breast cancer in BREAST CANCER RESEARCH
  • 1995-01. The relation of body size to plasma levels of estrogens and androgens in premenopausal women (Maryland, United States) in CANCER CAUSES & CONTROL
  • 1997-07. Cigarette smoking, sex hormones and bone density in women in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 1997-07. Associations of alcohol, height, and reproductive factors with serum hormone concentrations in postmenopausal Japanese women in BREAST CANCER RESEARCH AND TREATMENT
  • 1995-04. Reproductive Hormones and Menstrual Changes with Exercise in Female Athletes in SPORTS MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1023/a:1008929714862

    DOI

    http://dx.doi.org/10.1023/a:1008929714862

    DIMENSIONS

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    PUBMED

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    50 schema:description Objective: To investigate the relationships between plasma concentrations of sex hormones and risk factors for breast cancer.Methods: We investigated the relationship of plasma concentrations of estradiol, progesterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and sex hormone-binding globulin (SHBG) with breast cancer risk factors in 636 premenopausal and 456 postmenopausal women. Risk factor data were obtained from questionnaires and hormone concentrations measured by immunoassays; variations in geometric means were compared using analysis of covariance.Results: SHBG decreased with increasing body mass index and increasing waist–hip ratio both in pre- and postmenopausal women. In postmenopausal women only, estradiol increased with increasing body mass index. In premenopausal women, estradiol decreased with increasing physical activity, estradiol was higher in current than in ex- and non-smokers, and FSH decreased with increasing alcohol intake. No associations were observed between sex hormones and age at menarche, parity, age at menopause, and previous use of oral contraceptives in either pre- or postmenopausal women.Conclusions: Certain factors such as obesity and perhaps waist–hip ratio, physical activity and alcohol consumption, but probably not age at menarche and parity, may mediate their effects on breast cancer risk by changing circulating concentrations of sex hormones.
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