Association of the 5′ HS4 sequence of the chicken β‐globin locus control region with human EF1α gene promoter induces ubiquitous ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-06

AUTHORS

Frédérique Taboit‐Dameron, Benoit Malassagne, Céline Viglietta, Claudine Puissant, Mathieu Leroux‐Coyau, Christiane Chéreau, Joé Attal, Bernard Weill, Louis‐Marie Houdebine

ABSTRACT

Whatever its field of application, animal transgenesis aims at a high level of reproducible and stable transgene expression. In the case of xenotransplantation, prevention of hyperacute rejection of grafts of animal origin requires the use of organs expressing human inhibitors of complement activation such as CD55 (DAF) and CD59. Pigs transgenic for these molecules have been produced, but with low and variable levels of expression. In order to improve cDNA expression, a vector containing the 5'HS4 region from the LCR of the chicken beta-globin locus and the promoter and the first intron from the human EF1 alpha gene, was used to co-express human CD55 and CD59 cDNAs in transgenic rabbits. The transgenic lines with the 5'HS4 region displayed dramatically enhanced CD55 and CD59 mRNA concentrations in brain, heart, kidney, liver, lung, muscle, spleen and aortic endothelial cells in comparison with the transgenic lines without the 5'HS4 region. In the absence of the 5'HS4 region, only some of the transgenic lines displayed specific mRNAs and at low levels. Human CD55 and CD59 proteins were detectable in mononuclear cells from transgenic rabbits although at a lower level than in human mononuclear cells. On the other hand, primary aortic endothelial cells from a bi-transgenic line were very efficiently protected in vitro against human complement-dependent lysis. Transgenic rabbits harbouring the two human inhibitors of complement activation, CD55 and CD59, can therefore be used as new models in xenotransplantation. Moreover, the vector containing the 5'HS4 region from the LCR of the chicken beta-globin locus seems appropriate not only for xenotransplantation but also for any other studies involving transgenic animals in which cDNAs have to be expressed at a high level in all cell types. More... »

PAGES

223-235

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1008919925303

DOI

http://dx.doi.org/10.1023/a:1008919925303

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009308455

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10478492


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Genetically Modified", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD55 Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD59 Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CHO Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chickens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Complement Inactivator Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cricetinae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Complementary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Globins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Graft Rejection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Locus Control Region", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Elongation Factor 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Elongation Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rabbits", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Heterologous", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Laboratoire de Diff\u00e9renciation Cellulaire, Institut National de Recherche Agronomique, 78352, Jouy\u2010en\u2010Josas Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taboit\u2010Dameron", 
        "givenName": "Fr\u00e9d\u00e9rique", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire de Diff\u00e9renciation Cellulaire, Institut National de Recherche Agronomique, 78352, Jouy\u2010en\u2010Josas Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malassagne", 
        "givenName": "Benoit", 
        "id": "sg:person.0665372756.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665372756.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire de Diff\u00e9renciation Cellulaire, Institut National de Recherche Agronomique, 78352, Jouy\u2010en\u2010Josas Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Viglietta", 
        "givenName": "C\u00e9line", 
        "id": "sg:person.0601603277.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601603277.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire de Diff\u00e9renciation Cellulaire, Institut National de Recherche Agronomique, 78352, Jouy\u2010en\u2010Josas Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Puissant", 
        "givenName": "Claudine", 
        "id": "sg:person.0623654112.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623654112.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire de Diff\u00e9renciation Cellulaire, Institut National de Recherche Agronomique, 78352, Jouy\u2010en\u2010Josas Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leroux\u2010Coyau", 
        "givenName": "Mathieu", 
        "id": "sg:person.01357660103.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357660103.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire d'Immunologie, Facult\u00e9 de Cochin\u2010Port Royal, Universit\u00e9, Paris V, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ch\u00e9reau", 
        "givenName": "Christiane", 
        "id": "sg:person.01177337204.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177337204.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire de Diff\u00e9renciation Cellulaire, Institut National de Recherche Agronomique, 78352, Jouy\u2010en\u2010Josas Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Attal", 
        "givenName": "Jo\u00e9", 
        "id": "sg:person.0736374544.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736374544.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire d'Immunologie, Facult\u00e9 de Cochin\u2010Port Royal, Universit\u00e9, Paris V, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weill", 
        "givenName": "Bernard", 
        "id": "sg:person.0753744467.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753744467.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire de Diff\u00e9renciation Cellulaire, Institut National de Recherche Agronomique, 78352, Jouy\u2010en\u2010Josas Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Houdebine", 
        "givenName": "Louis\u2010Marie", 
        "id": "sg:person.01221277576.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221277576.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1101/gad.12.18.2852", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000969084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(93)90115-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003485264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(93)90115-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003485264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(96)00815-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004419437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1997.3831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004867683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.2.575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005936574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(90)90091-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008623407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(90)90091-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008623407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(87)90021-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013321498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(87)90122-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014873815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(87)90122-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014873815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0168-1656(95)00047-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015818854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0397-239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022614305", 
          "https://doi.org/10.1038/nbt0397-239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0995-964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023785816", 
          "https://doi.org/10.1038/nm0995-964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-0436.1991.tb00256.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024738605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/16.16.5037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029227932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.160.5.1558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029587356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199108000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030140230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199108000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030140230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)80052-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030579809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.iy.07.040189.000343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032511370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/aja.1002000403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032828625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.88.2.478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032998767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01969417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037452943", 
          "https://doi.org/10.1007/bf01969417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01969417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037452943", 
          "https://doi.org/10.1007/bf01969417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199112000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039964162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199112000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039964162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(98)80012-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041278231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(87)90584-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041471577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje.0.1300522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045467509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/25.5.995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051143754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199011000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053661075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199011000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053661075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199602270-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199602270-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199602270-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199604270-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199604270-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199604270-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199605270-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199605270-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199605270-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199711270-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199711270-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199711270-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.271.5252.1123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062552305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077283102", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077285970", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078808707", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079038753", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-06", 
    "datePublishedReg": "1999-06-01", 
    "description": "Whatever its field of application, animal transgenesis aims at a high level of reproducible and stable transgene expression. In the case of xenotransplantation, prevention of hyperacute rejection of grafts of animal origin requires the use of organs expressing human inhibitors of complement activation such as CD55 (DAF) and CD59. Pigs transgenic for these molecules have been produced, but with low and variable levels of expression. In order to improve cDNA expression, a vector containing the 5'HS4 region from the LCR of the chicken beta-globin locus and the promoter and the first intron from the human EF1 alpha gene, was used to co-express human CD55 and CD59 cDNAs in transgenic rabbits. The transgenic lines with the 5'HS4 region displayed dramatically enhanced CD55 and CD59 mRNA concentrations in brain, heart, kidney, liver, lung, muscle, spleen and aortic endothelial cells in comparison with the transgenic lines without the 5'HS4 region. In the absence of the 5'HS4 region, only some of the transgenic lines displayed specific mRNAs and at low levels. Human CD55 and CD59 proteins were detectable in mononuclear cells from transgenic rabbits although at a lower level than in human mononuclear cells. On the other hand, primary aortic endothelial cells from a bi-transgenic line were very efficiently protected in vitro against human complement-dependent lysis. Transgenic rabbits harbouring the two human inhibitors of complement activation, CD55 and CD59, can therefore be used as new models in xenotransplantation. Moreover, the vector containing the 5'HS4 region from the LCR of the chicken beta-globin locus seems appropriate not only for xenotransplantation but also for any other studies involving transgenic animals in which cDNAs have to be expressed at a high level in all cell types.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1023/a:1008919925303", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1102526", 
        "issn": [
          "0962-8819", 
          "1573-9368"
        ], 
        "name": "Transgenic Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Association of the 5\u2032 HS4 sequence of the chicken \u03b2\u2010globin locus control region with human EF1\u03b1 gene promoter induces ubiquitous and high expression of human CD55 and CD59 cDNAs in transgenic rabbits", 
    "pagination": "223-235", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2c57600da0e4cf63176819d97a8428b805510c87b42682a42af83a0dcda2ade0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10478492"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9209120"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1008919925303"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1009308455"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1008919925303", 
      "https://app.dimensions.ai/details/publication/pub.1009308455"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000498.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1023/A:1008919925303"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1008919925303'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1008919925303'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1008919925303'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1008919925303'


 

This table displays all metadata directly associated to this object as RDF triples.

319 TRIPLES      21 PREDICATES      83 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1008919925303 schema:about N09134595f98b44ccaddfa90479c860e8
2 N2ff48630b21c495083544b9f2a468b70
3 N33c0227fbae34bff9f5dbf48ff1384b6
4 N33dbda6cd24b46aaad61972edf3313fe
5 N3a64e3febfb54483912b5bfabe656148
6 N478ce27bd9c748608bee95be44f676d3
7 N47e5b74c0beb4aa4a1f5edb2b0f2a895
8 N4face1f4a3bf4d58b5b331ab4bb75387
9 N51f3d74a18d047e586ecbf504edde7c3
10 N5947a6641db24227b12a0c545c251040
11 N8d54747318904eccbde3dd691ad6b3eb
12 N94071a511ffb4da2be0e0bd182837f17
13 Na66df7447a644d68a640c60fe1330c11
14 Nae70d61d4b244411be49abe3a29ba417
15 Nb740c82c9d63417db2dbb3b99570377e
16 Nb9a1e171dc064ad7a34c90a24c299b02
17 Nbd6a8b9a53464713b6bb756843f230fd
18 Nc50990a35b554da4b66c8c491c06de51
19 Ncff76c581568496aaafa329928e93e00
20 anzsrc-for:11
21 anzsrc-for:1107
22 schema:author Na8a94f5b01414535bfd04446df0c2eb8
23 schema:citation sg:pub.10.1007/bf01969417
24 sg:pub.10.1038/nbt0397-239
25 sg:pub.10.1038/nm0995-964
26 https://app.dimensions.ai/details/publication/pub.1077283102
27 https://app.dimensions.ai/details/publication/pub.1077285970
28 https://app.dimensions.ai/details/publication/pub.1078808707
29 https://app.dimensions.ai/details/publication/pub.1079038753
30 https://doi.org/10.1002/aja.1002000403
31 https://doi.org/10.1006/excr.1997.3831
32 https://doi.org/10.1016/0003-2697(87)90021-2
33 https://doi.org/10.1016/0014-5793(96)00815-0
34 https://doi.org/10.1016/0092-8674(87)90584-8
35 https://doi.org/10.1016/0092-8674(93)80052-g
36 https://doi.org/10.1016/0168-1656(95)00047-t
37 https://doi.org/10.1016/0378-1119(87)90122-3
38 https://doi.org/10.1016/0378-1119(90)90091-5
39 https://doi.org/10.1016/0378-1119(93)90115-j
40 https://doi.org/10.1016/s0955-0674(98)80012-4
41 https://doi.org/10.1073/pnas.88.2.478
42 https://doi.org/10.1073/pnas.94.2.575
43 https://doi.org/10.1084/jem.160.5.1558
44 https://doi.org/10.1093/emboj/16.16.5037
45 https://doi.org/10.1093/nar/25.5.995
46 https://doi.org/10.1097/00007890-199011000-00015
47 https://doi.org/10.1097/00007890-199108000-00006
48 https://doi.org/10.1097/00007890-199112000-00001
49 https://doi.org/10.1097/00007890-199602270-00012
50 https://doi.org/10.1097/00007890-199604270-00021
51 https://doi.org/10.1097/00007890-199605270-00018
52 https://doi.org/10.1097/00007890-199711270-00002
53 https://doi.org/10.1101/gad.12.18.2852
54 https://doi.org/10.1111/j.1432-0436.1991.tb00256.x
55 https://doi.org/10.1126/science.271.5252.1123
56 https://doi.org/10.1146/annurev.iy.07.040189.000343
57 https://doi.org/10.1530/eje.0.1300522
58 schema:datePublished 1999-06
59 schema:datePublishedReg 1999-06-01
60 schema:description Whatever its field of application, animal transgenesis aims at a high level of reproducible and stable transgene expression. In the case of xenotransplantation, prevention of hyperacute rejection of grafts of animal origin requires the use of organs expressing human inhibitors of complement activation such as CD55 (DAF) and CD59. Pigs transgenic for these molecules have been produced, but with low and variable levels of expression. In order to improve cDNA expression, a vector containing the 5'HS4 region from the LCR of the chicken beta-globin locus and the promoter and the first intron from the human EF1 alpha gene, was used to co-express human CD55 and CD59 cDNAs in transgenic rabbits. The transgenic lines with the 5'HS4 region displayed dramatically enhanced CD55 and CD59 mRNA concentrations in brain, heart, kidney, liver, lung, muscle, spleen and aortic endothelial cells in comparison with the transgenic lines without the 5'HS4 region. In the absence of the 5'HS4 region, only some of the transgenic lines displayed specific mRNAs and at low levels. Human CD55 and CD59 proteins were detectable in mononuclear cells from transgenic rabbits although at a lower level than in human mononuclear cells. On the other hand, primary aortic endothelial cells from a bi-transgenic line were very efficiently protected in vitro against human complement-dependent lysis. Transgenic rabbits harbouring the two human inhibitors of complement activation, CD55 and CD59, can therefore be used as new models in xenotransplantation. Moreover, the vector containing the 5'HS4 region from the LCR of the chicken beta-globin locus seems appropriate not only for xenotransplantation but also for any other studies involving transgenic animals in which cDNAs have to be expressed at a high level in all cell types.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree false
64 schema:isPartOf N1ff56eaf8a7c49178b7875c69f882616
65 N7dc831b4e37541cdaf28e356a0b38b35
66 sg:journal.1102526
67 schema:name Association of the 5′ HS4 sequence of the chicken β‐globin locus control region with human EF1α gene promoter induces ubiquitous and high expression of human CD55 and CD59 cDNAs in transgenic rabbits
68 schema:pagination 223-235
69 schema:productId N4b7e52220a7f4a46b2e6fc66828805f1
70 N73d509bb713f4f6896fdf3098802e46f
71 N7985d2fb37504dc98934cd61bd9a3fe8
72 N7cede701446949d4882d9db228ff9206
73 N7f9e02f9252445f9a6ac9df15bbeb5da
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009308455
75 https://doi.org/10.1023/a:1008919925303
76 schema:sdDatePublished 2019-04-10T23:21
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher N10e4cff393b047328080cb0cb03b49a3
79 schema:url http://link.springer.com/10.1023/A:1008919925303
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N02c22e4779154a518cb4f8860638782d schema:name Laboratoire de Différenciation Cellulaire, Institut National de Recherche Agronomique, 78352, Jouy‐en‐Josas Cedex, France
84 rdf:type schema:Organization
85 N031ccb6d5e64467abe5fdf2959ba1340 rdf:first sg:person.01357660103.99
86 rdf:rest Nd7d77e5ebcd8471e979fd863d83dc479
87 N09134595f98b44ccaddfa90479c860e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Rabbits
89 rdf:type schema:DefinedTerm
90 N0cb659898a734f42a58f49bd41c314d0 schema:name Laboratoire de Différenciation Cellulaire, Institut National de Recherche Agronomique, 78352, Jouy‐en‐Josas Cedex, France
91 rdf:type schema:Organization
92 N0f1666fab4c6485cb39663b59f1da636 rdf:first sg:person.0665372756.65
93 rdf:rest N1e49feb83aeb4867a7ee87a8c0617a5d
94 N10e4cff393b047328080cb0cb03b49a3 schema:name Springer Nature - SN SciGraph project
95 rdf:type schema:Organization
96 N13a4175a82774b4581800d58574a8412 rdf:first sg:person.0753744467.42
97 rdf:rest N64834776b6d8461c99cdfd6951cbf3f0
98 N19904d8008b348feb3787863784695e9 schema:name Laboratoire de Différenciation Cellulaire, Institut National de Recherche Agronomique, 78352, Jouy‐en‐Josas Cedex, France
99 rdf:type schema:Organization
100 N1e49feb83aeb4867a7ee87a8c0617a5d rdf:first sg:person.0601603277.66
101 rdf:rest Nb0aa44d53e1e44fdbd1317d67f6956e1
102 N1ff56eaf8a7c49178b7875c69f882616 schema:issueNumber 3
103 rdf:type schema:PublicationIssue
104 N2a676ec3cf374ac8b5a51daf9d29878b schema:name Laboratoire de Différenciation Cellulaire, Institut National de Recherche Agronomique, 78352, Jouy‐en‐Josas Cedex, France
105 rdf:type schema:Organization
106 N2ff48630b21c495083544b9f2a468b70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Promoter Regions, Genetic
108 rdf:type schema:DefinedTerm
109 N33c0227fbae34bff9f5dbf48ff1384b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Locus Control Region
111 rdf:type schema:DefinedTerm
112 N33dbda6cd24b46aaad61972edf3313fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Graft Rejection
114 rdf:type schema:DefinedTerm
115 N3a64e3febfb54483912b5bfabe656148 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Chickens
117 rdf:type schema:DefinedTerm
118 N478ce27bd9c748608bee95be44f676d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Cricetinae
120 rdf:type schema:DefinedTerm
121 N47e5b74c0beb4aa4a1f5edb2b0f2a895 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Humans
123 rdf:type schema:DefinedTerm
124 N4b7e52220a7f4a46b2e6fc66828805f1 schema:name nlm_unique_id
125 schema:value 9209120
126 rdf:type schema:PropertyValue
127 N4face1f4a3bf4d58b5b331ab4bb75387 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name CD59 Antigens
129 rdf:type schema:DefinedTerm
130 N51f3d74a18d047e586ecbf504edde7c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name DNA, Complementary
132 rdf:type schema:DefinedTerm
133 N5947a6641db24227b12a0c545c251040 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Gene Expression Regulation
135 rdf:type schema:DefinedTerm
136 N602b1685eebf45148f57aeea9a335539 schema:name Laboratoire de Différenciation Cellulaire, Institut National de Recherche Agronomique, 78352, Jouy‐en‐Josas Cedex, France
137 rdf:type schema:Organization
138 N638a25dc7efe40bca4e20bf98c947016 rdf:first sg:person.0736374544.68
139 rdf:rest N13a4175a82774b4581800d58574a8412
140 N64834776b6d8461c99cdfd6951cbf3f0 rdf:first sg:person.01221277576.70
141 rdf:rest rdf:nil
142 N64e98300a83b43c9b9a1cf23e562fbc1 schema:name Laboratoire d'Immunologie, Faculté de Cochin‐Port Royal, Université, Paris V, France
143 rdf:type schema:Organization
144 N6920c29f5fe345b19ac5047267bf5ff9 schema:name Laboratoire d'Immunologie, Faculté de Cochin‐Port Royal, Université, Paris V, France
145 rdf:type schema:Organization
146 N73d509bb713f4f6896fdf3098802e46f schema:name pubmed_id
147 schema:value 10478492
148 rdf:type schema:PropertyValue
149 N7985d2fb37504dc98934cd61bd9a3fe8 schema:name readcube_id
150 schema:value 2c57600da0e4cf63176819d97a8428b805510c87b42682a42af83a0dcda2ade0
151 rdf:type schema:PropertyValue
152 N7cede701446949d4882d9db228ff9206 schema:name doi
153 schema:value 10.1023/a:1008919925303
154 rdf:type schema:PropertyValue
155 N7dc831b4e37541cdaf28e356a0b38b35 schema:volumeNumber 8
156 rdf:type schema:PublicationVolume
157 N7f9e02f9252445f9a6ac9df15bbeb5da schema:name dimensions_id
158 schema:value pub.1009308455
159 rdf:type schema:PropertyValue
160 N8d54747318904eccbde3dd691ad6b3eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Globins
162 rdf:type schema:DefinedTerm
163 N90594bc4728f4500987b82b21d80d087 schema:name Laboratoire de Différenciation Cellulaire, Institut National de Recherche Agronomique, 78352, Jouy‐en‐Josas Cedex, France
164 rdf:type schema:Organization
165 N94071a511ffb4da2be0e0bd182837f17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name CD55 Antigens
167 rdf:type schema:DefinedTerm
168 Na66df7447a644d68a640c60fe1330c11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Transplantation, Heterologous
170 rdf:type schema:DefinedTerm
171 Na78457e18c654a42894ee82f3805a012 schema:affiliation N02c22e4779154a518cb4f8860638782d
172 schema:familyName Taboit‐Dameron
173 schema:givenName Frédérique
174 rdf:type schema:Person
175 Na8a94f5b01414535bfd04446df0c2eb8 rdf:first Na78457e18c654a42894ee82f3805a012
176 rdf:rest N0f1666fab4c6485cb39663b59f1da636
177 Nae70d61d4b244411be49abe3a29ba417 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Animals
179 rdf:type schema:DefinedTerm
180 Naef2efea439542fda0601ab14e2523b2 schema:name Laboratoire de Différenciation Cellulaire, Institut National de Recherche Agronomique, 78352, Jouy‐en‐Josas Cedex, France
181 rdf:type schema:Organization
182 Nb0aa44d53e1e44fdbd1317d67f6956e1 rdf:first sg:person.0623654112.65
183 rdf:rest N031ccb6d5e64467abe5fdf2959ba1340
184 Nb740c82c9d63417db2dbb3b99570377e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name CHO Cells
186 rdf:type schema:DefinedTerm
187 Nb9a1e171dc064ad7a34c90a24c299b02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Animals, Genetically Modified
189 rdf:type schema:DefinedTerm
190 Nbd6a8b9a53464713b6bb756843f230fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Peptide Elongation Factors
192 rdf:type schema:DefinedTerm
193 Nc50990a35b554da4b66c8c491c06de51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Complement Inactivator Proteins
195 rdf:type schema:DefinedTerm
196 Ncff76c581568496aaafa329928e93e00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Peptide Elongation Factor 1
198 rdf:type schema:DefinedTerm
199 Nd7d77e5ebcd8471e979fd863d83dc479 rdf:first sg:person.01177337204.54
200 rdf:rest N638a25dc7efe40bca4e20bf98c947016
201 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
202 schema:name Medical and Health Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
205 schema:name Immunology
206 rdf:type schema:DefinedTerm
207 sg:journal.1102526 schema:issn 0962-8819
208 1573-9368
209 schema:name Transgenic Research
210 rdf:type schema:Periodical
211 sg:person.01177337204.54 schema:affiliation N6920c29f5fe345b19ac5047267bf5ff9
212 schema:familyName Chéreau
213 schema:givenName Christiane
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177337204.54
215 rdf:type schema:Person
216 sg:person.01221277576.70 schema:affiliation N90594bc4728f4500987b82b21d80d087
217 schema:familyName Houdebine
218 schema:givenName Louis‐Marie
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221277576.70
220 rdf:type schema:Person
221 sg:person.01357660103.99 schema:affiliation N602b1685eebf45148f57aeea9a335539
222 schema:familyName Leroux‐Coyau
223 schema:givenName Mathieu
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357660103.99
225 rdf:type schema:Person
226 sg:person.0601603277.66 schema:affiliation N2a676ec3cf374ac8b5a51daf9d29878b
227 schema:familyName Viglietta
228 schema:givenName Céline
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601603277.66
230 rdf:type schema:Person
231 sg:person.0623654112.65 schema:affiliation Naef2efea439542fda0601ab14e2523b2
232 schema:familyName Puissant
233 schema:givenName Claudine
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623654112.65
235 rdf:type schema:Person
236 sg:person.0665372756.65 schema:affiliation N19904d8008b348feb3787863784695e9
237 schema:familyName Malassagne
238 schema:givenName Benoit
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665372756.65
240 rdf:type schema:Person
241 sg:person.0736374544.68 schema:affiliation N0cb659898a734f42a58f49bd41c314d0
242 schema:familyName Attal
243 schema:givenName Joé
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736374544.68
245 rdf:type schema:Person
246 sg:person.0753744467.42 schema:affiliation N64e98300a83b43c9b9a1cf23e562fbc1
247 schema:familyName Weill
248 schema:givenName Bernard
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753744467.42
250 rdf:type schema:Person
251 sg:pub.10.1007/bf01969417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037452943
252 https://doi.org/10.1007/bf01969417
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/nbt0397-239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022614305
255 https://doi.org/10.1038/nbt0397-239
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/nm0995-964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023785816
258 https://doi.org/10.1038/nm0995-964
259 rdf:type schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1077283102 schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1077285970 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1078808707 schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1079038753 schema:CreativeWork
264 https://doi.org/10.1002/aja.1002000403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032828625
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1006/excr.1997.3831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004867683
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/0003-2697(87)90021-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013321498
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/0014-5793(96)00815-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004419437
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/0092-8674(87)90584-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041471577
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/0092-8674(93)80052-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1030579809
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/0168-1656(95)00047-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1015818854
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/0378-1119(87)90122-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014873815
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/0378-1119(90)90091-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008623407
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/0378-1119(93)90115-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1003485264
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/s0955-0674(98)80012-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041278231
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1073/pnas.88.2.478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032998767
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1073/pnas.94.2.575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005936574
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1084/jem.160.5.1558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029587356
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1093/emboj/16.16.5037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029227932
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1093/nar/25.5.995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051143754
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1097/00007890-199011000-00015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053661075
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1097/00007890-199108000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030140230
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1097/00007890-199112000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039964162
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1097/00007890-199602270-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060275716
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1097/00007890-199604270-00021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060275852
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1097/00007890-199605270-00018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060275908
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1097/00007890-199711270-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060276991
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1101/gad.12.18.2852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000969084
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1111/j.1432-0436.1991.tb00256.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024738605
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1126/science.271.5252.1123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552305
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1146/annurev.iy.07.040189.000343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032511370
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1530/eje.0.1300522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045467509
319 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...