Characterization of the three-compartment gel-entrapment porcine hepatocyte bioartificial liver View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-07

AUTHORS

T.D. Sielaff, S.L. Nyberg, M.D. Rollins, M.Y. Hu, B. Amiot, A. Lee, F.J. Wu, W.-S. Hu, F.B. Cerra

ABSTRACT

A hybrid bioartificial liver device supporting a large mass of cells expressing differentiated hepatocyte metabolic capabilities is necessary for the successful treatment of fulminant hepatic failure. The three-compartment gel-entrapment porcine hepatocyte bioartificial liver was designed to provide "bridge" support to transplantation or until native liver recovery is achieved for patients with acute liver failure. The device is an automated mammalian cell culture system supporting 6-7 × 109 porcine hepatocytes entrapped in a collagen matrix and inoculated into the capillary lumen spaces of two 100 kDa molecular mass cut-off hollow fiber bioreactors. Gel contraction recreates a small lumen space within the hollow fiber which allows for the delivery of a nutrient medium. This configuration supported hepatocyte viability and differentiated phenotype as measured by albumin synthesis, ureagenesis, oxygen consumption, and vital dye staining during both cell culture and ex vivo application. The hollow fiber membrane was also shown to isolate the cells from xenogenic immunoglobulin attack. The gel-entrapment bioartificial liver maintained a large mass of functional hepatocytes by providing a three-dimensional cell culture matrix, by delivering basal nutrients through lumen media perfusion, and by preventing rejection of the xenocytes. These features make this device a favorable candidate for the treatment of clinical fulminant hepatic failure. More... »

PAGES

357-364

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1007499727772

DOI

http://dx.doi.org/10.1023/a:1007499727772

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026828436

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9298256


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