Toxoplasma gondii induces the secretion of monocyte chemotactic protein-1 in human fibroblasts, in vitro View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-06

AUTHORS

Marie-Pierre Brenier-Pinchart, Hervé Pelloux, Josiane Simon, Jérôme Ricard, Jean-Luc Bosson, Pierre Ambroise-Thomas

ABSTRACT

Secretion of Monocyte Chemotactic Protein-1 (MCP-1) by fibroblasts infected with Toxoplasma gondii was studied in vitro. A significantly higher MCP-1 secretion was observed 24 h after infection by live tachyzoites. Analysis of chemokine mRNA transcripts by RNase protection assay revealed that this MCP-1 secretion seems associated with increased MCP-1 mRNA expression. However, these increased levels of MCP-1 secretion and expression were not obtained after stimulation by heat-killed tachyzoites or parasites pre-treated by a specific inhibitor of phosphatidylcholine-specific phospholipase C (D609). Inhibition of parasite multiplication by pyrimethamine did not modify MCP-1 secretion. Thus, it appeared that the active penetration of T. gondii in cells was of major importance in the induction of MCP-1 secretion. None of the other chemokines studied by RNase protection assay (lymphotactin, RANTES, IP-10, MIP-1α, MIP-1β, IL-8, and I-309) were expressed after infection by live tachyzoites. We also found that MCP-1 secretion induced by live T. gondii is blocked by inhibitors of nuclear factor (NF)-κ activation, ALLN and MG132. Such data indicate that NF-κB could be involved in T. gondii-induced MCP-1 production. MCP-1 secretion may contribute to the recruitment of monocytes and lymphocytes and thus participate in the control of T. gondii infection and in its pathogenesis. More... »

PAGES

79-87

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1007075701551

DOI

http://dx.doi.org/10.1023/a:1007075701551

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006881411

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10942204


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