Chronic Effects of Xanthines on Levels of Central Receptors in Mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-12

AUTHORS

Dan Shi, John W. Daly

ABSTRACT

1.Chronic ingestion of caffeine causes a significant increase in levels of A1-adenosine, nicotinic and muscarinic receptors, serotonergic receptors, GABAA receptors and L-type calcium channels in cerebral cortical membranes from mice NIH Swiss strain mice.2.Chronic theophylline and paraxanthine had effects similar to those of caffeine except that levels of L-type channels were unchanged. Chronic theobromine, a weak adenosine antagonist, and 1-isobutyl-3-methylxanthine (IBMX), a potent adenosine antagonist and phosphodiesterase inhibitor, caused only an increase in levels of A1-adenosine receptors. A combination of chronic caffeine and IBMX had the same effects on receptors as caffeine alone. Chronic 3,7-dimethyl-1-propargylxanthine (DMPX), a somewhat selective A2A-antagonist, caused only an increase in levels of A1-adenosine receptors. Pentoxyfylline, an adenosine-uptake inhibitor inactive at adenosine receptors, had no effect on receptor levels or calcium channels.3.A comparison of plasma and brain levels of xanthines indicated that caffeine penetrated more readily and attained somewhat higher brain levels than theophylline or theobromine. Penetration and levels were even lower for IBMX, paraxanthine, DMPX, and pentoxyfylline.4.The results suggest that effective blockade of both A1 and A2A-adenosine receptors is necessary for the full spectrum of biochemical changes elicited by chronic ingestion of xanthines, such as caffeine, theophylline, and paraxanthine. More... »

PAGES

719-732

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1006901005925

DOI

http://dx.doi.org/10.1023/a:1006901005925

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006782245

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10456233


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "1-Methyl-3-isobutylxanthine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caffeine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium Channels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Central Nervous System Stimulants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebral Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Corpus Striatum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Interactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Tissue Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pentoxifylline", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radioligand Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Cholinergic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, GABA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Purinergic P1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Serotonin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Theobromine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Theophylline", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xanthines", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 20892, Bethesda, Maryland", 
          "id": "http://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 20892, Bethesda, Maryland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Dan", 
        "id": "sg:person.01275766434.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275766434.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 20892, Bethesda, Maryland", 
          "id": "http://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 20892, Bethesda, Maryland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Daly", 
        "givenName": "John W.", 
        "id": "sg:person.0632156674.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632156674.30"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00733753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041359096", 
          "https://doi.org/10.1007/bf00733753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-60963-3_9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044652300", 
          "https://doi.org/10.1007/978-3-642-60963-3_9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00165391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003896170", 
          "https://doi.org/10.1007/bf00165391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/00006450-199509000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011564102", 
          "https://doi.org/10.1203/00006450-199509000-00007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00569655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020494048", 
          "https://doi.org/10.1007/bf00569655"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-12", 
    "datePublishedReg": "1999-12-01", 
    "description": "Abstract1.Chronic ingestion of caffeine causes a significant increase in levels of A1-adenosine, nicotinic and muscarinic receptors, serotonergic receptors, GABAA receptors and L-type calcium channels in cerebral cortical membranes from mice NIH Swiss strain mice.2.Chronic theophylline and paraxanthine had effects similar to those of caffeine except that levels of L-type channels were unchanged. Chronic theobromine, a weak adenosine antagonist, and 1-isobutyl-3-methylxanthine (IBMX), a potent adenosine antagonist and phosphodiesterase inhibitor, caused only an increase in levels of A1-adenosine receptors. A combination of chronic caffeine and IBMX had the same effects on receptors as caffeine alone. Chronic 3,7-dimethyl-1-propargylxanthine (DMPX), a somewhat selective A2A-antagonist, caused only an increase in levels of A1-adenosine receptors. Pentoxyfylline, an adenosine-uptake inhibitor inactive at adenosine receptors, had no effect on receptor levels or calcium channels.3.A comparison of plasma and brain levels of xanthines indicated that caffeine penetrated more readily and attained somewhat higher brain levels than theophylline or theobromine. Penetration and levels were even lower for IBMX, paraxanthine, DMPX, and pentoxyfylline.4.The results suggest that effective blockade of both A1 and A2A-adenosine receptors is necessary for the full spectrum of biochemical changes elicited by chronic ingestion of xanthines, such as caffeine, theophylline, and paraxanthine.", 
    "genre": "article", 
    "id": "sg:pub.10.1023/a:1006901005925", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2716264", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2724772", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1092852", 
        "issn": [
          "0272-4340", 
          "1573-6830"
        ], 
        "name": "Cellular and Molecular Neurobiology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "A1 adenosine receptors", 
      "brain levels", 
      "adenosine antagonist", 
      "calcium channels", 
      "Swiss strain mice", 
      "L-type calcium channels", 
      "higher brain levels", 
      "cerebral cortical membranes", 
      "L-type channels", 
      "adenosine uptake inhibitor", 
      "potent adenosine antagonist", 
      "A2A adenosine receptors", 
      "serotonergic receptors", 
      "Comparison of plasma", 
      "muscarinic receptors", 
      "chronic caffeine", 
      "chronic ingestion", 
      "GABAA receptors", 
      "strain mice", 
      "receptor levels", 
      "cortical membranes", 
      "central receptors", 
      "A1 adenosine", 
      "effective blockade", 
      "phosphodiesterase inhibitor", 
      "chronic effects", 
      "adenosine receptors", 
      "receptors", 
      "significant increase", 
      "biochemical changes", 
      "antagonist", 
      "pentoxyfylline", 
      "mice", 
      "ingestion", 
      "caffeine", 
      "IBMX", 
      "paraxanthine", 
      "inhibitors", 
      "xanthine", 
      "same effect", 
      "levels", 
      "chronic", 
      "DMPX", 
      "blockade", 
      "full spectrum", 
      "increase", 
      "effect", 
      "A1", 
      "plasma", 
      "theobromine", 
      "changes", 
      "combination", 
      "membrane", 
      "comparison", 
      "channels", 
      "penetration", 
      "results", 
      "spectra"
    ], 
    "name": "Chronic Effects of Xanthines on Levels of Central Receptors in Mice", 
    "pagination": "719-732", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1006782245"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1006901005925"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10456233"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1006901005925", 
      "https://app.dimensions.ai/details/publication/pub.1006782245"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_335.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1023/a:1006901005925"
  }
]
 

Download the RDF metadata as:Ā  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1006901005925'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1006901005925'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1006901005925'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1006901005925'


 

This table displays all metadata directly associated to this object as RDF triples.

242 TRIPLES      21 PREDICATES      112 URIs      99 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1006901005925 schema:about N32d9b13f08e1481f9c280bf401e64781
2 N360a19cda03a4e54896e171b6a35fe5e
3 N3f475a4369614428bfd7280dd02011fb
4 N46562b9c30b74951a8ac68e247bc7862
5 N53001fdf4008442ebe38b288062bdb28
6 N55369195189d450aa4a5b41cb039dd64
7 N614fbe556f224c6fbcaceb5fa92a9ed7
8 N6437822c9db345928668b6c7b44bccd8
9 N6c4dcec32d2b4c34a786172bdc55745d
10 N9268bd624db245d39213025aa4a831ad
11 N9fe0518ebe40407395baee3936a7ed45
12 Nad1803cecf05440caa987bae491b1cbe
13 Nb77f65b80261491aa1fbe926fc256aa4
14 Nc0e6ba8586614510a818aad5c923b86c
15 Ncb805659e3df41219114cf73f7084c2b
16 Nd9fc8fa3ae1b4f7e9d71701fe2534a62
17 Nde3c0235de964de193cd03a5104abacd
18 Ne26325ee17b14c509351a6aef2ba35a2
19 Ne85887125c9a47c59234b26f9232c564
20 Neabe990b7674479fbccbcf3142047b64
21 Nf0aea5826a8642faa128cbbc6ff88b34
22 Nfba627ef240e45c287b48a057f3cc56f
23 Nfd0b2236d08e482ea56f8f99c807bb4c
24 anzsrc-for:11
25 anzsrc-for:1109
26 schema:author Ndb093515e7a94a0aba376dc2c2526534
27 schema:citation sg:pub.10.1007/978-3-642-60963-3_9
28 sg:pub.10.1007/bf00165391
29 sg:pub.10.1007/bf00569655
30 sg:pub.10.1007/bf00733753
31 sg:pub.10.1203/00006450-199509000-00007
32 schema:datePublished 1999-12
33 schema:datePublishedReg 1999-12-01
34 schema:description Abstract1.Chronic ingestion of caffeine causes a significant increase in levels of A1-adenosine, nicotinic and muscarinic receptors, serotonergic receptors, GABAA receptors and L-type calcium channels in cerebral cortical membranes from mice NIH Swiss strain mice.2.Chronic theophylline and paraxanthine had effects similar to those of caffeine except that levels of L-type channels were unchanged. Chronic theobromine, a weak adenosine antagonist, and 1-isobutyl-3-methylxanthine (IBMX), a potent adenosine antagonist and phosphodiesterase inhibitor, caused only an increase in levels of A1-adenosine receptors. A combination of chronic caffeine and IBMX had the same effects on receptors as caffeine alone. Chronic 3,7-dimethyl-1-propargylxanthine (DMPX), a somewhat selective A2A-antagonist, caused only an increase in levels of A1-adenosine receptors. Pentoxyfylline, an adenosine-uptake inhibitor inactive at adenosine receptors, had no effect on receptor levels or calcium channels.3.A comparison of plasma and brain levels of xanthines indicated that caffeine penetrated more readily and attained somewhat higher brain levels than theophylline or theobromine. Penetration and levels were even lower for IBMX, paraxanthine, DMPX, and pentoxyfylline.4.The results suggest that effective blockade of both A1 and A2A-adenosine receptors is necessary for the full spectrum of biochemical changes elicited by chronic ingestion of xanthines, such as caffeine, theophylline, and paraxanthine.
35 schema:genre article
36 schema:isAccessibleForFree false
37 schema:isPartOf Nf1bbdd769fab416eb8029bcc6d9c67e8
38 Nf479bd135b5040388a04b248770bfede
39 sg:journal.1092852
40 schema:keywords A1
41 A1 adenosine
42 A1 adenosine receptors
43 A2A adenosine receptors
44 Comparison of plasma
45 DMPX
46 GABAA receptors
47 IBMX
48 L-type calcium channels
49 L-type channels
50 Swiss strain mice
51 adenosine antagonist
52 adenosine receptors
53 adenosine uptake inhibitor
54 antagonist
55 biochemical changes
56 blockade
57 brain levels
58 caffeine
59 calcium channels
60 central receptors
61 cerebral cortical membranes
62 changes
63 channels
64 chronic
65 chronic caffeine
66 chronic effects
67 chronic ingestion
68 combination
69 comparison
70 cortical membranes
71 effect
72 effective blockade
73 full spectrum
74 higher brain levels
75 increase
76 ingestion
77 inhibitors
78 levels
79 membrane
80 mice
81 muscarinic receptors
82 paraxanthine
83 penetration
84 pentoxyfylline
85 phosphodiesterase inhibitor
86 plasma
87 potent adenosine antagonist
88 receptor levels
89 receptors
90 results
91 same effect
92 serotonergic receptors
93 significant increase
94 spectra
95 strain mice
96 theobromine
97 xanthine
98 schema:name Chronic Effects of Xanthines on Levels of Central Receptors in Mice
99 schema:pagination 719-732
100 schema:productId N922ffc02ecd045119f097d50e16c6a58
101 N9d9175ccee924bc5b700adadea29fc65
102 Nd45c97a4d9ca444b8c6247941285c749
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006782245
104 https://doi.org/10.1023/a:1006901005925
105 schema:sdDatePublished 2022-09-02T15:49
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher Nb9d6677a9f17461dbbe5713b62dc5a64
108 schema:url https://doi.org/10.1023/a:1006901005925
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N32d9b13f08e1481f9c280bf401e64781 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Receptors, Cholinergic
114 rdf:type schema:DefinedTerm
115 N360a19cda03a4e54896e171b6a35fe5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Radioligand Assay
117 rdf:type schema:DefinedTerm
118 N3f475a4369614428bfd7280dd02011fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Mice
120 rdf:type schema:DefinedTerm
121 N46562b9c30b74951a8ac68e247bc7862 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Nerve Tissue Proteins
123 rdf:type schema:DefinedTerm
124 N53001fdf4008442ebe38b288062bdb28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Animals
126 rdf:type schema:DefinedTerm
127 N55369195189d450aa4a5b41cb039dd64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Receptors, Serotonin
129 rdf:type schema:DefinedTerm
130 N5728a1f1daa5486592b56669300a01cf rdf:first sg:person.0632156674.30
131 rdf:rest rdf:nil
132 N614fbe556f224c6fbcaceb5fa92a9ed7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Xanthines
134 rdf:type schema:DefinedTerm
135 N6437822c9db345928668b6c7b44bccd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cerebral Cortex
137 rdf:type schema:DefinedTerm
138 N6c4dcec32d2b4c34a786172bdc55745d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Brain Chemistry
140 rdf:type schema:DefinedTerm
141 N922ffc02ecd045119f097d50e16c6a58 schema:name doi
142 schema:value 10.1023/a:1006901005925
143 rdf:type schema:PropertyValue
144 N9268bd624db245d39213025aa4a831ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Corpus Striatum
146 rdf:type schema:DefinedTerm
147 N9d9175ccee924bc5b700adadea29fc65 schema:name dimensions_id
148 schema:value pub.1006782245
149 rdf:type schema:PropertyValue
150 N9fe0518ebe40407395baee3936a7ed45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Theophylline
152 rdf:type schema:DefinedTerm
153 Nad1803cecf05440caa987bae491b1cbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Theobromine
155 rdf:type schema:DefinedTerm
156 Nb77f65b80261491aa1fbe926fc256aa4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Pentoxifylline
158 rdf:type schema:DefinedTerm
159 Nb9d6677a9f17461dbbe5713b62dc5a64 schema:name Springer Nature - SN SciGraph project
160 rdf:type schema:Organization
161 Nc0e6ba8586614510a818aad5c923b86c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Gene Expression Regulation
163 rdf:type schema:DefinedTerm
164 Ncb805659e3df41219114cf73f7084c2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Drug Interactions
166 rdf:type schema:DefinedTerm
167 Nd45c97a4d9ca444b8c6247941285c749 schema:name pubmed_id
168 schema:value 10456233
169 rdf:type schema:PropertyValue
170 Nd9fc8fa3ae1b4f7e9d71701fe2534a62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Receptors, GABA
172 rdf:type schema:DefinedTerm
173 Ndb093515e7a94a0aba376dc2c2526534 rdf:first sg:person.01275766434.88
174 rdf:rest N5728a1f1daa5486592b56669300a01cf
175 Nde3c0235de964de193cd03a5104abacd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Central Nervous System Stimulants
177 rdf:type schema:DefinedTerm
178 Ne26325ee17b14c509351a6aef2ba35a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Receptors, Purinergic P1
180 rdf:type schema:DefinedTerm
181 Ne85887125c9a47c59234b26f9232c564 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Receptors, Drug
183 rdf:type schema:DefinedTerm
184 Neabe990b7674479fbccbcf3142047b64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name 1-Methyl-3-isobutylxanthine
186 rdf:type schema:DefinedTerm
187 Nf0aea5826a8642faa128cbbc6ff88b34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Male
189 rdf:type schema:DefinedTerm
190 Nf1bbdd769fab416eb8029bcc6d9c67e8 schema:volumeNumber 19
191 rdf:type schema:PublicationVolume
192 Nf479bd135b5040388a04b248770bfede schema:issueNumber 6
193 rdf:type schema:PublicationIssue
194 Nfba627ef240e45c287b48a057f3cc56f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Calcium Channels
196 rdf:type schema:DefinedTerm
197 Nfd0b2236d08e482ea56f8f99c807bb4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Caffeine
199 rdf:type schema:DefinedTerm
200 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
201 schema:name Medical and Health Sciences
202 rdf:type schema:DefinedTerm
203 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
204 schema:name Neurosciences
205 rdf:type schema:DefinedTerm
206 sg:grant.2716264 http://pending.schema.org/fundedItem sg:pub.10.1023/a:1006901005925
207 rdf:type schema:MonetaryGrant
208 sg:grant.2724772 http://pending.schema.org/fundedItem sg:pub.10.1023/a:1006901005925
209 rdf:type schema:MonetaryGrant
210 sg:journal.1092852 schema:issn 0272-4340
211 1573-6830
212 schema:name Cellular and Molecular Neurobiology
213 schema:publisher Springer Nature
214 rdf:type schema:Periodical
215 sg:person.01275766434.88 schema:affiliation grid-institutes:grid.94365.3d
216 schema:familyName Shi
217 schema:givenName Dan
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275766434.88
219 rdf:type schema:Person
220 sg:person.0632156674.30 schema:affiliation grid-institutes:grid.94365.3d
221 schema:familyName Daly
222 schema:givenName John W.
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632156674.30
224 rdf:type schema:Person
225 sg:pub.10.1007/978-3-642-60963-3_9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044652300
226 https://doi.org/10.1007/978-3-642-60963-3_9
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/bf00165391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003896170
229 https://doi.org/10.1007/bf00165391
230 rdf:type schema:CreativeWork
231 sg:pub.10.1007/bf00569655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020494048
232 https://doi.org/10.1007/bf00569655
233 rdf:type schema:CreativeWork
234 sg:pub.10.1007/bf00733753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041359096
235 https://doi.org/10.1007/bf00733753
236 rdf:type schema:CreativeWork
237 sg:pub.10.1203/00006450-199509000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011564102
238 https://doi.org/10.1203/00006450-199509000-00007
239 rdf:type schema:CreativeWork
240 grid-institutes:grid.94365.3d schema:alternateName Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 20892, Bethesda, Maryland
241 schema:name Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 20892, Bethesda, Maryland
242 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...