The Blood–Brain Barrier and Bilirubin Encephalopathy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-02

AUTHORS

Richard P. Wennberg

ABSTRACT

1. The pathogenesis of bilirubin encephalopathy is multifactorial, involving the transport of bilirubin or albumin/bilirubin across the blood–brain barrier and delivering bilirubin to target neurons.2. The relative importance of the blood–brain barrier, unconjugated bilirubin levels, serum binding, and tissue susceptibility in this process is only partially understood. Even at dangerously high serum levels, bilirubin traverses the intact blood–brain barrier slowly, requiring time for encephalopathy to occur, although deposition of bilirubin can be rapid if a surge in plasma unbound bilirubin is produced by administering a drug which competes with bilirubin for binding to albumin.3. There may be maturational changes in permeability both in the fetus and postnatally which protect the brain from bilirubin.4. Disruption or partial disruption of the blood–brain barrier by disease or hypoxic ischemic injury will facilitate transport of bilirubin/albumin into brain, but the relative affinities of albumin and target neurons will determine whether the tissue bilirubin load is sufficient for toxicity to occur. More... »

PAGES

97-109

References to SciGraph publications

  • 1989-10. The Effects of Bilirubin on Brain Energy Metabolism during Hyperosmolar Opening of the Blood-Brain Barrier: An In Vivo Study Using 31P Nuclear Magnetic Resonance Spectroscopy in PEDIATRIC RESEARCH
  • 1997-08. The multidrug-resistance P-glycoprotein (Pgp, MDR1) is an early marker of blood-brain barrier development in the microvessels of the developing human brain in HISTOCHEMISTRY AND CELL BIOLOGY
  • 1985-09. Bilirubin Toxicity in Neural Cell Lines N115 and NBR10A in PEDIATRIC RESEARCH
  • 1998-11. Brain Bilirubin Content Is Increased in P-Glycoprotein-Deficient Transgenic Null Mutant Mice in PEDIATRIC RESEARCH
  • 1989-05. Permeability of the Blood Brain Barrier for 125I-Albumin-Bound Bilirubin in Newborn Piglets in PEDIATRIC RESEARCH
  • 1985-06. Brain Bilirubin Deposition and Brain Blood Flow during Acute Urea-Induced Hyperosmolality in Newborn Piglets in PEDIATRIC RESEARCH
  • 1976-07. Structure of bilirubin in NATURE
  • 1974-12. Effect of pH on the Interaction of Bilirubin with Albumin and Tissue Culture Cells in PEDIATRIC RESEARCH
  • 1985-07. The Effects of Brain Blood Flow on Brain Bilirubin Deposition in Newborn Piglets in PEDIATRIC RESEARCH
  • 1993-07. Brainstem Bilirubin Toxicity in the Newborn Primate May Be Promoted and Reversed by Modulating PCO2 in PEDIATRIC RESEARCH
  • 1990-05. Blood-Brain Barrier Permeability to Bilirubin in the Rat Studied Using Intracarotid Bolus Injection and in Situ Brain Perfusion Techniques in PEDIATRIC RESEARCH
  • 1956-12. Bilirubin, an Uncoupler of Oxidative Phosphorylation in Isolated Mitochondria in NATURE
  • 1988-04. The Importance of Free Bilirubin Acid Salt in Bilirubin Uptake by Erythrocytes and Mitochondria in PEDIATRIC RESEARCH
  • 1986-06. Changes in the Auditory Brainstem Response Associated with Intravenous Infusion of Unconjugated Bilirubin into Infant Rhesus Monkeys in PEDIATRIC RESEARCH
  • 1987-08. The in Vivo Effect of Bilirubin and Sulfisoxazole on Cerebral Oxygen, Glucose, and Lactate Metabolism in Newborn Piglets in PEDIATRIC RESEARCH
  • 1986-08. Experimental Bilirubin Encephalopathy: Importance of Total Bilirubin, Protein Binding, and Blood-Brain Barrier in PEDIATRIC RESEARCH
  • 1991-11. Bilirubin-Induced Changes in Brain Energy Metabolism after Osmotic Opening of the Blood-Brain Barrier in PEDIATRIC RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1023/a:1006900111744

    DOI

    http://dx.doi.org/10.1023/a:1006900111744

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006918567

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10690504


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