Cyclosporin A binding in mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-09

AUTHORS

A.P. Halestrap, C.P. Connern, E.J. Griffiths, P.M. Kerr

ABSTRACT

When loaded with high (pathological) levels of Ca2+, mitochondria become swollen and uncoupled as the result of a large nonspecific increase in membrane permeability. This process, known as the mitochondrial permeability transition (MPT), is exacerbated by oxidative stress and adenine nucleotide depletion. These conditions match those that a heart experiences during reperfusion following a period of ischaemia. The MPT is caused by the opening of a non-specific pore that can be prevented by sub-micromolar concentrations of cyclosporin A (CsA). A variety of conditions that increase the sensitivity of pore opening to [Ca2+], such as thiol modification, oxidative stress, increased matrix volume and chaotropic agents, all enhance the binding of matrix cyclophilin (CyP) to the inner mitochondrial membrane in a CsA-sensitive manner. In contrast, ADP, membrane potential and low pH decrease the sensitivity of pore opening to [Ca2+] without affecting CyP binding. We present a model of pore opening involving CyP binding to a membrane target protein followed by Ca(2+)-dependent triggering of a conformational change to induce channel opening. Using the ischaemic/reperfused rat heart we have shown that the mitochondrial pore does not open during ischaemia, but does do so during reperfusion. Recovery of heart during reperfusion is improved in the presence of 0.2 microM CsA, suggesting that the MPT may be critical in the transition from reversible to irreversible reperfusion injury. More... »

PAGES

167-172

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1006879618176

DOI

http://dx.doi.org/10.1023/a:1006879618176

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022858166

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9309682


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclosporine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intracellular Membranes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondria, Heart", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondrial Swelling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Reperfusion Injury", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptidylprolyl Isomerase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Permeability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Bristol", 
          "id": "https://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "Department of Biochemistry, University of Bristol, BS8 1TD, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Halestrap", 
        "givenName": "A.P.", 
        "id": "sg:person.01076235114.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076235114.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bristol", 
          "id": "https://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "Department of Biochemistry, University of Bristol, BS8 1TD, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Connern", 
        "givenName": "C.P.", 
        "id": "sg:person.01364751310.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364751310.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bristol", 
          "id": "https://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "Department of Cardiac Surgery, University of Bristol, BS8 1TD, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Griffiths", 
        "givenName": "E.J.", 
        "id": "sg:person.0676776135.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676776135.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bristol", 
          "id": "https://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "Department of Cardiac Surgery, University of Bristol, BS8 1TD, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kerr", 
        "givenName": "P.M.", 
        "id": "sg:person.0614367257.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614367257.52"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0022-2828(91)90181-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018705005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3020321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018768316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3020321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018768316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2780715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018978219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2780715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018978219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-9861(79)90371-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021006394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2840381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021253196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2840381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021253196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3070099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031889195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3070099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031889195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3070093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032060606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3070093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032060606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmcc.1993.1162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037124548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(92)80616-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041773637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi9525177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055211166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi9525177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055211166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077405178", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.1995.268.3.c676", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082557325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082752888", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1997-09", 
    "datePublishedReg": "1997-09-01", 
    "description": "When loaded with high (pathological) levels of Ca2+, mitochondria become swollen and uncoupled as the result of a large nonspecific increase in membrane permeability. This process, known as the mitochondrial permeability transition (MPT), is exacerbated by oxidative stress and adenine nucleotide depletion. These conditions match those that a heart experiences during reperfusion following a period of ischaemia. The MPT is caused by the opening of a non-specific pore that can be prevented by sub-micromolar concentrations of cyclosporin A (CsA). A variety of conditions that increase the sensitivity of pore opening to [Ca2+], such as thiol modification, oxidative stress, increased matrix volume and chaotropic agents, all enhance the binding of matrix cyclophilin (CyP) to the inner mitochondrial membrane in a CsA-sensitive manner. In contrast, ADP, membrane potential and low pH decrease the sensitivity of pore opening to [Ca2+] without affecting CyP binding. We present a model of pore opening involving CyP binding to a membrane target protein followed by Ca(2+)-dependent triggering of a conformational change to induce channel opening. Using the ischaemic/reperfused rat heart we have shown that the mitochondrial pore does not open during ischaemia, but does do so during reperfusion. Recovery of heart during reperfusion is improved in the presence of 0.2 microM CsA, suggesting that the MPT may be critical in the transition from reversible to irreversible reperfusion injury.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1023/a:1006879618176", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1016672", 
        "issn": [
          "0300-8177", 
          "1573-4919"
        ], 
        "name": "Molecular and Cellular Biochemistry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1-2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "174"
      }
    ], 
    "name": "Cyclosporin A binding in mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury", 
    "pagination": "167-172", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6ce69bb30cd563457724812c684bb4f637d5eb69f1fc19d5a0f94c9c32e6ee36"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9309682"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0364456"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1006879618176"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022858166"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1006879618176", 
      "https://app.dimensions.ai/details/publication/pub.1022858166"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000499.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1023/A:1006879618176"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1006879618176'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1006879618176'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1006879618176'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1006879618176'


 

This table displays all metadata directly associated to this object as RDF triples.

176 TRIPLES      21 PREDICATES      54 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1006879618176 schema:about N288bdea27ff44fba84d8ccb3af61565f
2 N4e65dd29c1af451e96c047560b010c33
3 N577edf39bd0d4111a71ad81a877050fa
4 N810dc077532444e89b5cbdb13e0b4cac
5 N8e41881750aa434da8b7c6e77b497581
6 Na0c5c89fc6b742caae6bac7b420da31a
7 Ndf32bb7f3dea4c01add47fe38be26026
8 Ne2505898fde044b38bcb89a6847eb517
9 Neec1b686d3b04d429436aa5f21c2d763
10 Nf28b6d06ab4b433088450fdd5fd3bec9
11 Nf4fda829a5354ec7b2ad1895390e6e0d
12 Nfe9bf82716ab47979b2d58673d12e11e
13 anzsrc-for:06
14 anzsrc-for:0601
15 schema:author Nd399985b468a4f3ca0f0ab0d92a252d4
16 schema:citation https://app.dimensions.ai/details/publication/pub.1077405178
17 https://app.dimensions.ai/details/publication/pub.1082752888
18 https://doi.org/10.1006/jmcc.1993.1162
19 https://doi.org/10.1016/0003-9861(79)90371-0
20 https://doi.org/10.1016/0014-5793(92)80616-o
21 https://doi.org/10.1016/0022-2828(91)90181-k
22 https://doi.org/10.1021/bi9525177
23 https://doi.org/10.1042/bj2780715
24 https://doi.org/10.1042/bj2840381
25 https://doi.org/10.1042/bj3020321
26 https://doi.org/10.1042/bj3070093
27 https://doi.org/10.1042/bj3070099
28 https://doi.org/10.1152/ajpcell.1995.268.3.c676
29 schema:datePublished 1997-09
30 schema:datePublishedReg 1997-09-01
31 schema:description When loaded with high (pathological) levels of Ca2+, mitochondria become swollen and uncoupled as the result of a large nonspecific increase in membrane permeability. This process, known as the mitochondrial permeability transition (MPT), is exacerbated by oxidative stress and adenine nucleotide depletion. These conditions match those that a heart experiences during reperfusion following a period of ischaemia. The MPT is caused by the opening of a non-specific pore that can be prevented by sub-micromolar concentrations of cyclosporin A (CsA). A variety of conditions that increase the sensitivity of pore opening to [Ca2+], such as thiol modification, oxidative stress, increased matrix volume and chaotropic agents, all enhance the binding of matrix cyclophilin (CyP) to the inner mitochondrial membrane in a CsA-sensitive manner. In contrast, ADP, membrane potential and low pH decrease the sensitivity of pore opening to [Ca2+] without affecting CyP binding. We present a model of pore opening involving CyP binding to a membrane target protein followed by Ca(2+)-dependent triggering of a conformational change to induce channel opening. Using the ischaemic/reperfused rat heart we have shown that the mitochondrial pore does not open during ischaemia, but does do so during reperfusion. Recovery of heart during reperfusion is improved in the presence of 0.2 microM CsA, suggesting that the MPT may be critical in the transition from reversible to irreversible reperfusion injury.
32 schema:genre research_article
33 schema:inLanguage en
34 schema:isAccessibleForFree false
35 schema:isPartOf N3f23ac86b80f48fa812d4d981a3b50c1
36 N8fe3c36820ab4263aa08e47ac5f5189a
37 sg:journal.1016672
38 schema:name Cyclosporin A binding in mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury
39 schema:pagination 167-172
40 schema:productId N1dc3123c948341839814d119442411c9
41 N22cf199cb88848bcb6daa5c484130aa6
42 N89186efefec84820862a33bf28039ab8
43 Nef67de1cfaa34cc19a5d347e7f73577a
44 Nf9582b3d6eb142d78b14fffc2c9526ee
45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022858166
46 https://doi.org/10.1023/a:1006879618176
47 schema:sdDatePublished 2019-04-10T14:06
48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
49 schema:sdPublisher N7ea52be3f53e492880b3486bb0606a92
50 schema:url http://link.springer.com/10.1023/A:1006879618176
51 sgo:license sg:explorer/license/
52 sgo:sdDataset articles
53 rdf:type schema:ScholarlyArticle
54 N0b8d2aff1d2c463ba918086cdb06a54e rdf:first sg:person.0676776135.42
55 rdf:rest N7ae47990a63c4123b80844027a555789
56 N1dc3123c948341839814d119442411c9 schema:name doi
57 schema:value 10.1023/a:1006879618176
58 rdf:type schema:PropertyValue
59 N22cf199cb88848bcb6daa5c484130aa6 schema:name nlm_unique_id
60 schema:value 0364456
61 rdf:type schema:PropertyValue
62 N288bdea27ff44fba84d8ccb3af61565f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Animals
64 rdf:type schema:DefinedTerm
65 N3125e94952734158b0ade68710537655 rdf:first sg:person.01364751310.49
66 rdf:rest N0b8d2aff1d2c463ba918086cdb06a54e
67 N3f23ac86b80f48fa812d4d981a3b50c1 schema:volumeNumber 174
68 rdf:type schema:PublicationVolume
69 N4e65dd29c1af451e96c047560b010c33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Cyclosporine
71 rdf:type schema:DefinedTerm
72 N577edf39bd0d4111a71ad81a877050fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Mitochondrial Swelling
74 rdf:type schema:DefinedTerm
75 N7ae47990a63c4123b80844027a555789 rdf:first sg:person.0614367257.52
76 rdf:rest rdf:nil
77 N7ea52be3f53e492880b3486bb0606a92 schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 N810dc077532444e89b5cbdb13e0b4cac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Intracellular Membranes
81 rdf:type schema:DefinedTerm
82 N89186efefec84820862a33bf28039ab8 schema:name dimensions_id
83 schema:value pub.1022858166
84 rdf:type schema:PropertyValue
85 N8e41881750aa434da8b7c6e77b497581 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Mitochondria, Heart
87 rdf:type schema:DefinedTerm
88 N8fe3c36820ab4263aa08e47ac5f5189a schema:issueNumber 1-2
89 rdf:type schema:PublicationIssue
90 Na0c5c89fc6b742caae6bac7b420da31a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Protein Binding
92 rdf:type schema:DefinedTerm
93 Nd399985b468a4f3ca0f0ab0d92a252d4 rdf:first sg:person.01076235114.01
94 rdf:rest N3125e94952734158b0ade68710537655
95 Ndf32bb7f3dea4c01add47fe38be26026 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Permeability
97 rdf:type schema:DefinedTerm
98 Ne2505898fde044b38bcb89a6847eb517 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Peptidylprolyl Isomerase
100 rdf:type schema:DefinedTerm
101 Neec1b686d3b04d429436aa5f21c2d763 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Calcium
103 rdf:type schema:DefinedTerm
104 Nef67de1cfaa34cc19a5d347e7f73577a schema:name pubmed_id
105 schema:value 9309682
106 rdf:type schema:PropertyValue
107 Nf28b6d06ab4b433088450fdd5fd3bec9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Rats
109 rdf:type schema:DefinedTerm
110 Nf4fda829a5354ec7b2ad1895390e6e0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Humans
112 rdf:type schema:DefinedTerm
113 Nf9582b3d6eb142d78b14fffc2c9526ee schema:name readcube_id
114 schema:value 6ce69bb30cd563457724812c684bb4f637d5eb69f1fc19d5a0f94c9c32e6ee36
115 rdf:type schema:PropertyValue
116 Nfe9bf82716ab47979b2d58673d12e11e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Myocardial Reperfusion Injury
118 rdf:type schema:DefinedTerm
119 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
120 schema:name Biological Sciences
121 rdf:type schema:DefinedTerm
122 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
123 schema:name Biochemistry and Cell Biology
124 rdf:type schema:DefinedTerm
125 sg:journal.1016672 schema:issn 0300-8177
126 1573-4919
127 schema:name Molecular and Cellular Biochemistry
128 rdf:type schema:Periodical
129 sg:person.01076235114.01 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
130 schema:familyName Halestrap
131 schema:givenName A.P.
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076235114.01
133 rdf:type schema:Person
134 sg:person.01364751310.49 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
135 schema:familyName Connern
136 schema:givenName C.P.
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364751310.49
138 rdf:type schema:Person
139 sg:person.0614367257.52 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
140 schema:familyName Kerr
141 schema:givenName P.M.
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614367257.52
143 rdf:type schema:Person
144 sg:person.0676776135.42 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
145 schema:familyName Griffiths
146 schema:givenName E.J.
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676776135.42
148 rdf:type schema:Person
149 https://app.dimensions.ai/details/publication/pub.1077405178 schema:CreativeWork
150 https://app.dimensions.ai/details/publication/pub.1082752888 schema:CreativeWork
151 https://doi.org/10.1006/jmcc.1993.1162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037124548
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1016/0003-9861(79)90371-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021006394
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/0014-5793(92)80616-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1041773637
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/0022-2828(91)90181-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1018705005
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1021/bi9525177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055211166
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1042/bj2780715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018978219
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1042/bj2840381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021253196
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1042/bj3020321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018768316
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1042/bj3070093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032060606
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1042/bj3070099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031889195
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1152/ajpcell.1995.268.3.c676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082557325
172 rdf:type schema:CreativeWork
173 https://www.grid.ac/institutes/grid.5337.2 schema:alternateName University of Bristol
174 schema:name Department of Biochemistry, University of Bristol, BS8 1TD, Bristol, UK
175 Department of Cardiac Surgery, University of Bristol, BS8 1TD, Bristol, UK
176 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...