Insulin signal transduction through protein kinase cascades View Full Text


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Article Info

DATE

1998-05

AUTHORS

Joseph Avruch

ABSTRACT

This review summarizes the evolution of ideas concerning insulin signal transduction, the current information on protein ser/thr kinase cascades as signalling intermediates, and their status as participants in insulin regulation of energy metabolism. Best characterized is the Ras-MAPK pathway, whose input is crucial to cell fate decisions, but relatively dispensable in metabolic regulation. By contrast the effectors downstream of PI-3 kinase, although less well elucidated, include elements indispensable for the insulin regulation of glucose transport, glycogen and cAMP metabolism. Considerable information has accrued on PKB/cAkt, a protein kinase that interacts directly with Ptd Ins 3′OH phosphorylated lipids, as well as some of the elements further downstream, such as glycogen synthase kinase-3 and the p70 S6 kinase. Finally, some information implicates other erk pathways (e.g. such as the SAPK/JNK pathway) and Nck/cdc42-regulated PAKs (homologs of the yeast Ste 20) as participants in the cellular response to insulin. Thus insulin recruits a broad array of protein (ser/thr) kinases in its target cells to effectuate its characteristic anabolic and anticatabolic programs. More... »

PAGES

31-48

References to SciGraph publications

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  • 1995-08. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction in NATURE
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  • 1994-01. A brain serine/threonine protein kinase activated by Cdc42 and Rac1 in NATURE
  • 1993-05. p70s6k function is essential for G1 progression in NATURE
  • 1993-07. Protein kinase Cα activates RAF-1 by direct phosphorylation in NATURE
  • 1995-10. Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase in NATURE
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1023/a:1006823109415

    DOI

    http://dx.doi.org/10.1023/a:1006823109415

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039427668

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9609112


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