Ontology type: schema:ScholarlyArticle
2001-02
AUTHORSCharles D. Blanke, Michael Stipanov, Jason Morrow, Mace Rothenberg, Rebecca Chinery, Yu Shyr, Robert Coffey, David H. Johnson, Steven D. Leach, R. Daniel Beauchamp
ABSTRACTSix patients with incurable malignancies were originally treated with vitamin E, 3200 IU/day for fourteen days, followed by the same dose of vitamin E daily plus LCV (20 mg/m2 i.v. bolus daily x 5) with 5FU (425 mg/m2 i.v. bolus immediately following LCV). The same schedule of LCV and 5FU was repeated 4 weeks later, then every 5 weeks indefinitely. When 3 of the first 6 had grade 3/4 toxicity, six more patients were treated on the identical drugs and schedule. Seven of twelve total patients had one or more grade 3/4 toxicities. Neutropenia, abdominal pain, and diarrhea were most common. No patient had a documented response, though seven patients did have stable disease. Though the combination of vitamin E and chemotherapy was toxic, this trial demonstrated maximal therapeutic doses of vitamin E can be combined with standard 5FU and LCV, without significantly increasing the side effects of the chemotherapy itself. More... »
PAGES21-27
http://scigraph.springernature.com/pub.10.1023/a:1006484031959
DOIhttp://dx.doi.org/10.1023/a:1006484031959
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1013221790
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/11291830
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Abdominal Pain",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Combined Chemotherapy Protocols",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Diarrhea",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dinoprost",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dose-Response Relationship, Drug",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "F2-Isoprostanes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fluorouracil",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Infusions, Intravenous",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Leucovorin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neutropenia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Vitamin E",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Oregon Health & Science University",
"id": "https://www.grid.ac/institutes/grid.5288.7",
"name": [
"Division of Hematology and Medical Oncology, Department of Medicine, Oregon Health Sciences University, Portland, OR, USA"
],
"type": "Organization"
},
"familyName": "Blanke",
"givenName": "Charles D.",
"id": "sg:person.01235140446.77",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235140446.77"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vanderbilt University Medical Center",
"id": "https://www.grid.ac/institutes/grid.412807.8",
"name": [
"Division of Medical Oncology Department of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA"
],
"type": "Organization"
},
"familyName": "Stipanov",
"givenName": "Michael",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vanderbilt University Medical Center",
"id": "https://www.grid.ac/institutes/grid.412807.8",
"name": [
"Division of Clinical Pharmacology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA"
],
"type": "Organization"
},
"familyName": "Morrow",
"givenName": "Jason",
"id": "sg:person.01276263512.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276263512.00"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vanderbilt University Medical Center",
"id": "https://www.grid.ac/institutes/grid.412807.8",
"name": [
"Division of Medical Oncology Department of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA"
],
"type": "Organization"
},
"familyName": "Rothenberg",
"givenName": "Mace",
"id": "sg:person.012113360172.60",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012113360172.60"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.66875.3a",
"name": [
"GI Research Unit, Mayo Foundation, Rochester, MN, USA"
],
"type": "Organization"
},
"familyName": "Chinery",
"givenName": "Rebecca",
"id": "sg:person.01177724632.59",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177724632.59"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vanderbilt University Medical Center",
"id": "https://www.grid.ac/institutes/grid.412807.8",
"name": [
"Division of Biostatistics, Department of Preventive Medicine, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA"
],
"type": "Organization"
},
"familyName": "Shyr",
"givenName": "Yu",
"id": "sg:person.0657055157.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657055157.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vanderbilt University Medical Center",
"id": "https://www.grid.ac/institutes/grid.412807.8",
"name": [
"Division of Gastroenterology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA"
],
"type": "Organization"
},
"familyName": "Coffey",
"givenName": "Robert",
"id": "sg:person.01142442612.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142442612.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vanderbilt University Medical Center",
"id": "https://www.grid.ac/institutes/grid.412807.8",
"name": [
"Division of Medical Oncology Department of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA"
],
"type": "Organization"
},
"familyName": "Johnson",
"givenName": "David H.",
"id": "sg:person.014561237657.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014561237657.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vanderbilt University Medical Center",
"id": "https://www.grid.ac/institutes/grid.412807.8",
"name": [
"Division of Surgical Oncology, Department of General Surgery, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA"
],
"type": "Organization"
},
"familyName": "Leach",
"givenName": "Steven D.",
"id": "sg:person.015153213052.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015153213052.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vanderbilt University Medical Center",
"id": "https://www.grid.ac/institutes/grid.412807.8",
"name": [
"Division of Surgical Oncology, Department of General Surgery, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA"
],
"type": "Organization"
},
"familyName": "Beauchamp",
"givenName": "R. Daniel",
"id": "sg:person.01355254152.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355254152.34"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.3322/canjclin.45.1.31",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003261326"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19940315)73:6<1562::aid-cncr2820730606>3.0.co;2-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003367462"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.nu.12.070192.001035",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019759201"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/89.14.1006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028285469"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0076-6879(99)00106-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029934274"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1197-1233",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032828039",
"https://doi.org/10.1038/nm1197-1233"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(197411)34:5<1576::aid-cncr2820340503>3.0.co;2-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039330995"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.271.7.3667",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041075191"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.atv.17.11.2309",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063334433"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1991.9.11.1967",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077893824"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1987.5.10.1559",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1078843412"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1989.7.10.1407",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1078901137"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/ajcn/27.8.1174",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1080194978"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082459165",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/oxfordjournals.annonc.a058686",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082685627"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1997.15.2.808",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083054579"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083100069",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1998.16.1.301",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083201650"
],
"type": "CreativeWork"
}
],
"datePublished": "2001-02",
"datePublishedReg": "2001-02-01",
"description": "Six patients with incurable malignancies were originally treated with vitamin E, 3200 IU/day for fourteen days, followed by the same dose of vitamin E daily plus LCV (20 mg/m2 i.v. bolus daily x 5) with 5FU (425 mg/m2 i.v. bolus immediately following LCV). The same schedule of LCV and 5FU was repeated 4 weeks later, then every 5 weeks indefinitely. When 3 of the first 6 had grade 3/4 toxicity, six more patients were treated on the identical drugs and schedule. Seven of twelve total patients had one or more grade 3/4 toxicities. Neutropenia, abdominal pain, and diarrhea were most common. No patient had a documented response, though seven patients did have stable disease. Though the combination of vitamin E and chemotherapy was toxic, this trial demonstrated maximal therapeutic doses of vitamin E can be combined with standard 5FU and LCV, without significantly increasing the side effects of the chemotherapy itself.",
"genre": "research_article",
"id": "sg:pub.10.1023/a:1006484031959",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.2435709",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2438973",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2495328",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1094201",
"issn": [
"0167-6997",
"1573-0646"
],
"name": "Investigational New Drugs",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "19"
}
],
"name": "A Phase I Study of Vitamin E, 5-Fluorouracil and Leucovorin for Advanced Malignancies",
"pagination": "21-27",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"3efca4a17b78d13aa49e0c659a232f5b1c6379e9339beab58d5a40f555418a07"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"11291830"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8309330"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1023/a:1006484031959"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1013221790"
]
}
],
"sameAs": [
"https://doi.org/10.1023/a:1006484031959",
"https://app.dimensions.ai/details/publication/pub.1013221790"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T01:57",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000499.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1023/A:1006484031959"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1006484031959'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1006484031959'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1006484031959'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1006484031959'
This table displays all metadata directly associated to this object as RDF triples.
272 TRIPLES
21 PREDICATES
65 URIs
39 LITERALS
27 BLANK NODES