Change in Expression of ER, bcl-2 and MIB1 on Primary Tamoxifen and Relation to Response in ER Positive Breast Cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-01

AUTHORS

Frances S. Kenny, Peter C. Willsher, Julia M.W. Gee, Robert I. Nicholson, Sarah E. Pinder, Ian O. Ellis, John F.R. Robertson

ABSTRACT

Pre-treatment oestrogen receptor (ER) expression in breast cancer predicts for rate of response to endocrine therapy but not for the quality or duration of response (DofR). ER is known to be down-regulated by anti-oestrogens. This study has tested the hypothesis that the degree of down-regulation of ER and the ER-regulated marker bcl-2 are associated with the quality and duration of tamoxifen response. 80 patients with ER+ve breast cancer (H-score > 10) receiving primary tamoxifen (n = 51 Stage I-II elderly; n = 29 Stage III) underwent sequential tumour biopsies for immunocytochemical assessment of ER, bcl-2 and the proliferation marker MIB1. Median follow-up is 45 months. By 6-months on therapy three patients had attained complete response (CR), 27 partial response (PR); 44 static disease (SD) and six progression (PD) by UICC criteria. Greater decrease in ER and bcl-2 H-score from pre-treatment to 6 weeks (p = 0.035, p = 0.037) and ER and bcl-2 H-score from pre-treatment to 6 months (p = 0.058, p = 0.036) were significantly associated with better quality of response (CR/PR vs SD/PD). Greater 6-week and 6-month reduction in bcl-2 H-score (p = 0.041, p = 0.036) and 6-week reduction in MIB1 (p = 0.013) were significantly correlated with longer DofR. This study demonstrates that greater down-regulation of ER and the ER-regulated protein bcl-2 on primary tamoxifen are significantly associated with a better quality of response and bcl-2 and the proliferation marker MIB1 a longer duration of response in ER+ve breast cancer. More... »

PAGES

135-144

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1006469627067

DOI

http://dx.doi.org/10.1023/a:1006469627067

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016547350

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11261829


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Nuclear", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Hormonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Estrogen Antagonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Hormone-Dependent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-bcl-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Estrogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tamoxifen", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Nottingham City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412920.c", 
          "name": [
            "Professorial Unit of Surgery, Nottingham City Hospital, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kenny", 
        "givenName": "Frances S.", 
        "id": "sg:person.016434074244.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016434074244.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nottingham City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412920.c", 
          "name": [
            "Professorial Unit of Surgery, Nottingham City Hospital, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Willsher", 
        "givenName": "Peter C.", 
        "id": "sg:person.01347210454.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347210454.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiff University", 
          "id": "https://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Tenovus Cancer Research Centre, University of Wales College of Medicine, Tenovus Building, Heath Park, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gee", 
        "givenName": "Julia M.W.", 
        "id": "sg:person.012457220672.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012457220672.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiff University", 
          "id": "https://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Tenovus Cancer Research Centre, University of Wales College of Medicine, Tenovus Building, Heath Park, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nicholson", 
        "givenName": "Robert I.", 
        "id": "sg:person.0670333460.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670333460.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nottingham City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412920.c", 
          "name": [
            "Department of Histopathology, Nottingham City Hospital, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pinder", 
        "givenName": "Sarah E.", 
        "id": "sg:person.014576043464.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014576043464.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nottingham City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412920.c", 
          "name": [
            "Department of Histopathology, Nottingham City Hospital, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ellis", 
        "givenName": "Ian O.", 
        "id": "sg:person.01054612302.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054612302.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nottingham City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412920.c", 
          "name": [
            "Professorial Unit of Surgery, Nottingham City Hospital, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Robertson", 
        "givenName": "John F.R.", 
        "id": "sg:person.07764637207.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07764637207.20"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00689680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001943152", 
          "https://doi.org/10.1007/bf00689680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/erc.0.0020003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004003238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1711770109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005398947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1711770109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005398947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(74)91364-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006753414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(87)91071-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009400374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(87)91071-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009400374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(197703)39:3<1289::aid-cncr2820390340>3.0.co;2-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011360956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1005973529921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011756861", 
          "https://doi.org/10.1023/a:1005973529921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012787769", 
          "https://doi.org/10.1038/bjc.1996.357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012787769", 
          "https://doi.org/10.1038/bjc.1996.357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19880401)61:7<1345::aid-cncr2820610712>3.0.co;2-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015149428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0046-8177(95)90060-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021660057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01834641", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026991025", 
          "https://doi.org/10.1007/bf01834641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01807034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027372323", 
          "https://doi.org/10.1007/bf01807034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01807034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027372323", 
          "https://doi.org/10.1007/bf01807034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)80088-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027545646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)80088-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027545646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029242322", 
          "https://doi.org/10.1038/bjc.1994.22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029242322", 
          "https://doi.org/10.1038/bjc.1994.22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030008544", 
          "https://doi.org/10.1038/bjc.1994.476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030008544", 
          "https://doi.org/10.1038/bjc.1994.476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0277-5379(91)90145-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030573596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0959-8049(94)00327-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030710472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1005796915388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033774096", 
          "https://doi.org/10.1023/a:1005796915388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0959-8049(95)00517-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037353427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037546161", 
          "https://doi.org/10.1038/bjc.1996.500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037546161", 
          "https://doi.org/10.1038/bjc.1996.500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1993.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042923689", 
          "https://doi.org/10.1038/bjc.1993.111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1993.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042923689", 
          "https://doi.org/10.1038/bjc.1993.111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(20000301)85:5<643::aid-ijc8>3.0.co;2-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047649516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1995.338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047884760", 
          "https://doi.org/10.1038/bjc.1995.338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1995.338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047884760", 
          "https://doi.org/10.1038/bjc.1995.338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02307030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048338859", 
          "https://doi.org/10.1007/bf02307030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02307030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048338859", 
          "https://doi.org/10.1007/bf02307030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048661364", 
          "https://doi.org/10.1038/bjc.1996.2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048661364", 
          "https://doi.org/10.1038/bjc.1996.2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1993.tb01195.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050233815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1993.tb01195.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050233815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9776(97)90571-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050704687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910590508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051260168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1005760013810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051444015", 
          "https://doi.org/10.1023/a:1005760013810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1711680404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051457357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1711680404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051457357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.124.1.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052093322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076588661", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1992.10.8.1284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077159252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077661065", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079160338", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079953792", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082315630", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082435498", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1995.13.2.513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082532573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082538049", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082642160", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082724961", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082734074", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/172460089601100106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082932879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/172460089601100106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082932879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.annonc.a059064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082936505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1997.15.5.1916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083094774"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-01", 
    "datePublishedReg": "2001-01-01", 
    "description": "Pre-treatment oestrogen receptor (ER) expression in breast cancer predicts for rate of response to endocrine therapy but not for the quality or duration of response (DofR). ER is known to be down-regulated by anti-oestrogens. This study has tested the hypothesis that the degree of down-regulation of ER and the ER-regulated marker bcl-2 are associated with the quality and duration of tamoxifen response. 80 patients with ER+ve breast cancer (H-score > 10) receiving primary tamoxifen (n = 51 Stage I-II elderly; n = 29 Stage III) underwent sequential tumour biopsies for immunocytochemical assessment of ER, bcl-2 and the proliferation marker MIB1. Median follow-up is 45 months. By 6-months on therapy three patients had attained complete response (CR), 27 partial response (PR); 44 static disease (SD) and six progression (PD) by UICC criteria. Greater decrease in ER and bcl-2 H-score from pre-treatment to 6 weeks (p = 0.035, p = 0.037) and ER and bcl-2 H-score from pre-treatment to 6 months (p = 0.058, p = 0.036) were significantly associated with better quality of response (CR/PR vs SD/PD). Greater 6-week and 6-month reduction in bcl-2 H-score (p = 0.041, p = 0.036) and 6-week reduction in MIB1 (p = 0.013) were significantly correlated with longer DofR. This study demonstrates that greater down-regulation of ER and the ER-regulated protein bcl-2 on primary tamoxifen are significantly associated with a better quality of response and bcl-2 and the proliferation marker MIB1 a longer duration of response in ER+ve breast cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1023/a:1006469627067", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "65"
      }
    ], 
    "name": "Change in Expression of ER, bcl-2 and MIB1 on Primary Tamoxifen and Relation to Response in ER Positive Breast Cancer", 
    "pagination": "135-144", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4ed7bd0f74453943a14dcab68e7e505807c3909deb00828922111b592637c865"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11261829"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1006469627067"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016547350"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1006469627067", 
      "https://app.dimensions.ai/details/publication/pub.1016547350"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:13", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000499.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1023/A:1006469627067"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1006469627067'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1006469627067'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1006469627067'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1006469627067'


 

This table displays all metadata directly associated to this object as RDF triples.

321 TRIPLES      21 PREDICATES      91 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1006469627067 schema:about N1aca65f69dd9437cb17437404df6e813
2 N27d2e6e062354bad8d8b986248fd3ea3
3 N2f16731a5e044d608c2bba45db855e42
4 N368358e34c834f0f9c021d7194897803
5 N3e85b14d5c034ad88ef663155ce7f437
6 N658fba9028294ace93dedc61c3fa2b63
7 N6f09de14607b481fa07be0f3c9afcba7
8 N9bb63bfc046d4129bbf27deab7fef5af
9 Na8da15bc30de41498807de3e5efd308b
10 Nae0ca90dca05427eb6fed9482cb66ff8
11 Nbcc37da752564885abf85db88abc186e
12 Ncb1afd4a473c4902b039b59e458f8ecd
13 Nddc2f337f6484705b6d6f332ef6c0fbb
14 Ne9ade1fcce9b414bb0d667d9ddad406f
15 Nf3e8c303fd774e2f9c9c11d7fb3e2244
16 Nf4b47fa8ce8245f09879583949cf5fe3
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N7dda3d7d2c744956b5042515df364aef
20 schema:citation sg:pub.10.1007/bf00689680
21 sg:pub.10.1007/bf01807034
22 sg:pub.10.1007/bf01834641
23 sg:pub.10.1007/bf02307030
24 sg:pub.10.1023/a:1005760013810
25 sg:pub.10.1023/a:1005796915388
26 sg:pub.10.1023/a:1005973529921
27 sg:pub.10.1038/bjc.1993.111
28 sg:pub.10.1038/bjc.1994.22
29 sg:pub.10.1038/bjc.1994.476
30 sg:pub.10.1038/bjc.1995.338
31 sg:pub.10.1038/bjc.1996.2
32 sg:pub.10.1038/bjc.1996.357
33 sg:pub.10.1038/bjc.1996.500
34 https://app.dimensions.ai/details/publication/pub.1076588661
35 https://app.dimensions.ai/details/publication/pub.1077661065
36 https://app.dimensions.ai/details/publication/pub.1079160338
37 https://app.dimensions.ai/details/publication/pub.1079953792
38 https://app.dimensions.ai/details/publication/pub.1082315630
39 https://app.dimensions.ai/details/publication/pub.1082435498
40 https://app.dimensions.ai/details/publication/pub.1082538049
41 https://app.dimensions.ai/details/publication/pub.1082642160
42 https://app.dimensions.ai/details/publication/pub.1082724961
43 https://app.dimensions.ai/details/publication/pub.1082734074
44 https://doi.org/10.1002/(sici)1097-0215(20000301)85:5<643::aid-ijc8>3.0.co;2-z
45 https://doi.org/10.1002/1097-0142(197703)39:3<1289::aid-cncr2820390340>3.0.co;2-f
46 https://doi.org/10.1002/1097-0142(19880401)61:7<1345::aid-cncr2820610712>3.0.co;2-j
47 https://doi.org/10.1002/ijc.2910590508
48 https://doi.org/10.1002/path.1711680404
49 https://doi.org/10.1002/path.1711770109
50 https://doi.org/10.1016/0046-8177(95)90060-8
51 https://doi.org/10.1016/0277-5379(91)90145-4
52 https://doi.org/10.1016/0959-8049(94)00327-2
53 https://doi.org/10.1016/0959-8049(95)00517-x
54 https://doi.org/10.1016/s0140-6736(05)80088-1
55 https://doi.org/10.1016/s0140-6736(74)91364-6
56 https://doi.org/10.1016/s0140-6736(87)91071-3
57 https://doi.org/10.1016/s0960-9776(97)90571-3
58 https://doi.org/10.1083/jcb.124.1.1
59 https://doi.org/10.1093/oxfordjournals.annonc.a059064
60 https://doi.org/10.1111/j.1365-2559.1993.tb01195.x
61 https://doi.org/10.1177/172460089601100106
62 https://doi.org/10.1200/jco.1992.10.8.1284
63 https://doi.org/10.1200/jco.1995.13.2.513
64 https://doi.org/10.1200/jco.1997.15.5.1916
65 https://doi.org/10.1677/erc.0.0020003
66 schema:datePublished 2001-01
67 schema:datePublishedReg 2001-01-01
68 schema:description Pre-treatment oestrogen receptor (ER) expression in breast cancer predicts for rate of response to endocrine therapy but not for the quality or duration of response (DofR). ER is known to be down-regulated by anti-oestrogens. This study has tested the hypothesis that the degree of down-regulation of ER and the ER-regulated marker bcl-2 are associated with the quality and duration of tamoxifen response. 80 patients with ER+ve breast cancer (H-score > 10) receiving primary tamoxifen (n = 51 Stage I-II elderly; n = 29 Stage III) underwent sequential tumour biopsies for immunocytochemical assessment of ER, bcl-2 and the proliferation marker MIB1. Median follow-up is 45 months. By 6-months on therapy three patients had attained complete response (CR), 27 partial response (PR); 44 static disease (SD) and six progression (PD) by UICC criteria. Greater decrease in ER and bcl-2 H-score from pre-treatment to 6 weeks (p = 0.035, p = 0.037) and ER and bcl-2 H-score from pre-treatment to 6 months (p = 0.058, p = 0.036) were significantly associated with better quality of response (CR/PR vs SD/PD). Greater 6-week and 6-month reduction in bcl-2 H-score (p = 0.041, p = 0.036) and 6-week reduction in MIB1 (p = 0.013) were significantly correlated with longer DofR. This study demonstrates that greater down-regulation of ER and the ER-regulated protein bcl-2 on primary tamoxifen are significantly associated with a better quality of response and bcl-2 and the proliferation marker MIB1 a longer duration of response in ER+ve breast cancer.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree false
72 schema:isPartOf N67a05b475a1c4299a6db0b56d02d7424
73 Ne27d4a64246f4bae85b0344d0245c324
74 sg:journal.1092777
75 schema:name Change in Expression of ER, bcl-2 and MIB1 on Primary Tamoxifen and Relation to Response in ER Positive Breast Cancer
76 schema:pagination 135-144
77 schema:productId N19c8aa3f327849dc8dabbea3cedf3f65
78 N68b1a2ebc4da4d4889058bf0feb17c6d
79 N8b400327b1f24b1085d2b4a39e7d7adf
80 Na2276f98680346479c17241995cd15a0
81 Nb8c6969f1e93426bb73121fb3bb9b460
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016547350
83 https://doi.org/10.1023/a:1006469627067
84 schema:sdDatePublished 2019-04-11T00:13
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher Nb3630d93d8ef4bb49eefb9807a26a475
87 schema:url http://link.springer.com/10.1023/A:1006469627067
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N0d34eada84cc447aa478c899785f844c rdf:first sg:person.012457220672.07
92 rdf:rest N342d3a99098740d283cccb0df05a7d0d
93 N19c8aa3f327849dc8dabbea3cedf3f65 schema:name nlm_unique_id
94 schema:value 8111104
95 rdf:type schema:PropertyValue
96 N1aca65f69dd9437cb17437404df6e813 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Nuclear Proteins
98 rdf:type schema:DefinedTerm
99 N27d2e6e062354bad8d8b986248fd3ea3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Aged
101 rdf:type schema:DefinedTerm
102 N2f16731a5e044d608c2bba45db855e42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Humans
104 rdf:type schema:DefinedTerm
105 N342d3a99098740d283cccb0df05a7d0d rdf:first sg:person.0670333460.58
106 rdf:rest N85570fc8891a4854812af82d9534b3f9
107 N368358e34c834f0f9c021d7194897803 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Proto-Oncogene Proteins c-bcl-2
109 rdf:type schema:DefinedTerm
110 N3e85b14d5c034ad88ef663155ce7f437 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Immunohistochemistry
112 rdf:type schema:DefinedTerm
113 N658fba9028294ace93dedc61c3fa2b63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Antineoplastic Agents, Hormonal
115 rdf:type schema:DefinedTerm
116 N67a05b475a1c4299a6db0b56d02d7424 schema:volumeNumber 65
117 rdf:type schema:PublicationVolume
118 N68b1a2ebc4da4d4889058bf0feb17c6d schema:name dimensions_id
119 schema:value pub.1016547350
120 rdf:type schema:PropertyValue
121 N6f09de14607b481fa07be0f3c9afcba7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Down-Regulation
123 rdf:type schema:DefinedTerm
124 N7dda3d7d2c744956b5042515df364aef rdf:first sg:person.016434074244.26
125 rdf:rest Na522984bb0744634840b053b48923e14
126 N85570fc8891a4854812af82d9534b3f9 rdf:first sg:person.014576043464.09
127 rdf:rest Nde75c7cc8a8e4542b4eaeb0cb4fa5dae
128 N8b400327b1f24b1085d2b4a39e7d7adf schema:name doi
129 schema:value 10.1023/a:1006469627067
130 rdf:type schema:PropertyValue
131 N9bb63bfc046d4129bbf27deab7fef5af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Biomarkers, Tumor
133 rdf:type schema:DefinedTerm
134 Na2276f98680346479c17241995cd15a0 schema:name readcube_id
135 schema:value 4ed7bd0f74453943a14dcab68e7e505807c3909deb00828922111b592637c865
136 rdf:type schema:PropertyValue
137 Na522984bb0744634840b053b48923e14 rdf:first sg:person.01347210454.77
138 rdf:rest N0d34eada84cc447aa478c899785f844c
139 Na8da15bc30de41498807de3e5efd308b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Tamoxifen
141 rdf:type schema:DefinedTerm
142 Nae0ca90dca05427eb6fed9482cb66ff8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Neoplasms, Hormone-Dependent
144 rdf:type schema:DefinedTerm
145 Nb3630d93d8ef4bb49eefb9807a26a475 schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 Nb8c6969f1e93426bb73121fb3bb9b460 schema:name pubmed_id
148 schema:value 11261829
149 rdf:type schema:PropertyValue
150 Nbcc37da752564885abf85db88abc186e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Receptors, Estrogen
152 rdf:type schema:DefinedTerm
153 Ncb1afd4a473c4902b039b59e458f8ecd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Female
155 rdf:type schema:DefinedTerm
156 Nddc2f337f6484705b6d6f332ef6c0fbb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Estrogen Antagonists
158 rdf:type schema:DefinedTerm
159 Nde75c7cc8a8e4542b4eaeb0cb4fa5dae rdf:first sg:person.01054612302.65
160 rdf:rest Neff7dc86fc254aab80c087e05c64360f
161 Ne27d4a64246f4bae85b0344d0245c324 schema:issueNumber 2
162 rdf:type schema:PublicationIssue
163 Ne9ade1fcce9b414bb0d667d9ddad406f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Breast Neoplasms
165 rdf:type schema:DefinedTerm
166 Neff7dc86fc254aab80c087e05c64360f rdf:first sg:person.07764637207.20
167 rdf:rest rdf:nil
168 Nf3e8c303fd774e2f9c9c11d7fb3e2244 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Disease-Free Survival
170 rdf:type schema:DefinedTerm
171 Nf4b47fa8ce8245f09879583949cf5fe3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Antigens, Nuclear
173 rdf:type schema:DefinedTerm
174 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
175 schema:name Medical and Health Sciences
176 rdf:type schema:DefinedTerm
177 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
178 schema:name Oncology and Carcinogenesis
179 rdf:type schema:DefinedTerm
180 sg:journal.1092777 schema:issn 0167-6806
181 1573-7217
182 schema:name Breast Cancer Research and Treatment
183 rdf:type schema:Periodical
184 sg:person.01054612302.65 schema:affiliation https://www.grid.ac/institutes/grid.412920.c
185 schema:familyName Ellis
186 schema:givenName Ian O.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054612302.65
188 rdf:type schema:Person
189 sg:person.012457220672.07 schema:affiliation https://www.grid.ac/institutes/grid.5600.3
190 schema:familyName Gee
191 schema:givenName Julia M.W.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012457220672.07
193 rdf:type schema:Person
194 sg:person.01347210454.77 schema:affiliation https://www.grid.ac/institutes/grid.412920.c
195 schema:familyName Willsher
196 schema:givenName Peter C.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347210454.77
198 rdf:type schema:Person
199 sg:person.014576043464.09 schema:affiliation https://www.grid.ac/institutes/grid.412920.c
200 schema:familyName Pinder
201 schema:givenName Sarah E.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014576043464.09
203 rdf:type schema:Person
204 sg:person.016434074244.26 schema:affiliation https://www.grid.ac/institutes/grid.412920.c
205 schema:familyName Kenny
206 schema:givenName Frances S.
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016434074244.26
208 rdf:type schema:Person
209 sg:person.0670333460.58 schema:affiliation https://www.grid.ac/institutes/grid.5600.3
210 schema:familyName Nicholson
211 schema:givenName Robert I.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670333460.58
213 rdf:type schema:Person
214 sg:person.07764637207.20 schema:affiliation https://www.grid.ac/institutes/grid.412920.c
215 schema:familyName Robertson
216 schema:givenName John F.R.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07764637207.20
218 rdf:type schema:Person
219 sg:pub.10.1007/bf00689680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001943152
220 https://doi.org/10.1007/bf00689680
221 rdf:type schema:CreativeWork
222 sg:pub.10.1007/bf01807034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027372323
223 https://doi.org/10.1007/bf01807034
224 rdf:type schema:CreativeWork
225 sg:pub.10.1007/bf01834641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026991025
226 https://doi.org/10.1007/bf01834641
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/bf02307030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048338859
229 https://doi.org/10.1007/bf02307030
230 rdf:type schema:CreativeWork
231 sg:pub.10.1023/a:1005760013810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051444015
232 https://doi.org/10.1023/a:1005760013810
233 rdf:type schema:CreativeWork
234 sg:pub.10.1023/a:1005796915388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033774096
235 https://doi.org/10.1023/a:1005796915388
236 rdf:type schema:CreativeWork
237 sg:pub.10.1023/a:1005973529921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011756861
238 https://doi.org/10.1023/a:1005973529921
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/bjc.1993.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042923689
241 https://doi.org/10.1038/bjc.1993.111
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/bjc.1994.22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029242322
244 https://doi.org/10.1038/bjc.1994.22
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/bjc.1994.476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030008544
247 https://doi.org/10.1038/bjc.1994.476
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/bjc.1995.338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047884760
250 https://doi.org/10.1038/bjc.1995.338
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/bjc.1996.2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048661364
253 https://doi.org/10.1038/bjc.1996.2
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/bjc.1996.357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012787769
256 https://doi.org/10.1038/bjc.1996.357
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/bjc.1996.500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037546161
259 https://doi.org/10.1038/bjc.1996.500
260 rdf:type schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1076588661 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1077661065 schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1079160338 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1079953792 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1082315630 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1082435498 schema:CreativeWork
267 https://app.dimensions.ai/details/publication/pub.1082538049 schema:CreativeWork
268 https://app.dimensions.ai/details/publication/pub.1082642160 schema:CreativeWork
269 https://app.dimensions.ai/details/publication/pub.1082724961 schema:CreativeWork
270 https://app.dimensions.ai/details/publication/pub.1082734074 schema:CreativeWork
271 https://doi.org/10.1002/(sici)1097-0215(20000301)85:5<643::aid-ijc8>3.0.co;2-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1047649516
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1002/1097-0142(197703)39:3<1289::aid-cncr2820390340>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1011360956
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1002/1097-0142(19880401)61:7<1345::aid-cncr2820610712>3.0.co;2-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1015149428
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1002/ijc.2910590508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051260168
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1002/path.1711680404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051457357
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1002/path.1711770109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005398947
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/0046-8177(95)90060-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021660057
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/0277-5379(91)90145-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030573596
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/0959-8049(94)00327-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030710472
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/0959-8049(95)00517-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037353427
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/s0140-6736(05)80088-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027545646
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/s0140-6736(74)91364-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006753414
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s0140-6736(87)91071-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009400374
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/s0960-9776(97)90571-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050704687
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1083/jcb.124.1.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052093322
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1093/oxfordjournals.annonc.a059064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082936505
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1111/j.1365-2559.1993.tb01195.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050233815
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1177/172460089601100106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082932879
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1200/jco.1992.10.8.1284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077159252
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1200/jco.1995.13.2.513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082532573
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1200/jco.1997.15.5.1916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083094774
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1677/erc.0.0020003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004003238
314 rdf:type schema:CreativeWork
315 https://www.grid.ac/institutes/grid.412920.c schema:alternateName Nottingham City Hospital
316 schema:name Department of Histopathology, Nottingham City Hospital, Nottingham, UK
317 Professorial Unit of Surgery, Nottingham City Hospital, Nottingham, UK
318 rdf:type schema:Organization
319 https://www.grid.ac/institutes/grid.5600.3 schema:alternateName Cardiff University
320 schema:name Tenovus Cancer Research Centre, University of Wales College of Medicine, Tenovus Building, Heath Park, Cardiff, UK
321 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...