Clinicopathological characteristics of breast carcinomas with allelic loss in the p73 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-09

AUTHORS

Gemma Dominguez, Javier Silva, Jose M. Silva, Jose M. Garcia, Celia Miralles, Oscar Rodriguez, Eugenia Jareño, Mariano Provencio, Pilar España, Felix Bonilla

ABSTRACT

p73, a new member of the p53 family, has been mapped to chromosome 1p 36, a region where loss of heterozygosity (LOH) is frequently observed in primary human tumors. Allelic loss studies involving the 1p arm in breast carcinomas offer rates ranging from 13% to 75%, depending on the genetic interval being studied. We investigated LOH in an intragenic microsatellite marker, and those centromerically flanking the p73 gene, at 1p 36, and their correlations with patient age and 10 pathologic parameters in a series of 193 breast carcinomas. The LOH analysis was performed by amplifying DNA by PCR, using the five markers of the 1p 36 region (p73P1, D1S2694, D1S214, D1S2666 and D1S450). LOH was found in at least one of these markers in 27% of tumors. When we established the comparison between tumors with and without LOH and the distribution of the 10 pathologic parameters considered, we observed statistically significant differences in association with higher histologic grade (p = 0.02), more advanced pathological stage (p = 0.02), peritumoral vessel involvement (p = 0.04) and poorly differentiated carcinomas (p = 0.01), as well as in tumors that concomitantly exhibited lymph node metastases, peritumoral vessel involvement and absence of steroid receptors (p = 0.02). These data suggest that LOH in the p73 region could be pathogenically related to breast cancer and possibly to a poor tumor prognosis. More... »

PAGES

17-22

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1006446709715

DOI

http://dx.doi.org/10.1023/a:1006446709715

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048332920

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11079155


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Tumor Suppressor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Loss of Heterozygosity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microsatellite Repeats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Protein p73", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Departments of Medical Oncology Pathology, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dominguez", 
        "givenName": "Gemma", 
        "id": "sg:person.01166154641.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166154641.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Departments of Medical Oncology Pathology, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Silva", 
        "givenName": "Javier", 
        "id": "sg:person.0734126226.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734126226.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Departments of Medical Oncology Pathology, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Silva", 
        "givenName": "Jose M.", 
        "id": "sg:person.01012733370.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012733370.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Departments of Medical Oncology Pathology, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garcia", 
        "givenName": "Jose M.", 
        "id": "sg:person.014645712342.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014645712342.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Departments of Medical Oncology Pathology, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miralles", 
        "givenName": "Celia", 
        "id": "sg:person.01064017117.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064017117.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Puerta de Hierro Majadahonda", 
          "id": "https://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Pathology, Clinica Puerta de Hierro, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodriguez", 
        "givenName": "Oscar", 
        "id": "sg:person.01307647221.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307647221.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Hospital Santa Cristina, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jare\u00f1o", 
        "givenName": "Eugenia", 
        "id": "sg:person.01263634032.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263634032.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Departments of Medical Oncology Pathology, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Provencio", 
        "givenName": "Mariano", 
        "id": "sg:person.0726612567.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726612567.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Departments of Medical Oncology Pathology, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Espa\u00f1a", 
        "givenName": "Pilar", 
        "id": "sg:person.01314474117.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314474117.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Departments of Medical Oncology Pathology, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonilla", 
        "givenName": "Felix", 
        "id": "sg:person.01263153010.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263153010.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19981109)78:4<437::aid-ijc8>3.0.co;2-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002349998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19980115)82:2<323::aid-cncr11>3.0.co;2-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007170711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-419x(94)90009-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009946715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-419x(94)90009-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009946715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19941015)74:8<2281::aid-cncr2820740812>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019485637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.19.2.1438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024112852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2264(199903)24:3<255::aid-gcc11>3.0.co;2-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024198773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80275-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024825914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.2870050406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028326004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/38298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030867943", 
          "https://doi.org/10.1038/38298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/38298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030867943", 
          "https://doi.org/10.1038/38298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2264(199908)25:4<354::aid-gcc7>3.0.co;2-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036907990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2264(199608)16:4<211::aid-gcc1>3.0.co;2-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040432805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040576854", 
          "https://doi.org/10.1038/sj.bjc.6690234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040576854", 
          "https://doi.org/10.1038/sj.bjc.6690234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80540-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041015753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19961021)69:5<381::aid-ijc5>3.0.co;2-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043353251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19990621)84:3<321::aid-ijc21>3.0.co;2-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045130149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046360162", 
          "https://doi.org/10.1038/sj.onc.1202390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046360162", 
          "https://doi.org/10.1038/sj.onc.1202390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/ejso.1998.0626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047021691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.2870140402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047391050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abio.1993.1379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048662652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.13.2.319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071510763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074481984", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074488154", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074494999", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074496212", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079007915", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082475897", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083187481", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083226558", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083241017", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083276283", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083353318", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083376155", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-09", 
    "datePublishedReg": "2000-09-01", 
    "description": "p73, a new member of the p53 family, has been mapped to chromosome 1p 36, a region where loss of heterozygosity (LOH) is frequently observed in primary human tumors. Allelic loss studies involving the 1p arm in breast carcinomas offer rates ranging from 13% to 75%, depending on the genetic interval being studied. We investigated LOH in an intragenic microsatellite marker, and those centromerically flanking the p73 gene, at 1p 36, and their correlations with patient age and 10 pathologic parameters in a series of 193 breast carcinomas. The LOH analysis was performed by amplifying DNA by PCR, using the five markers of the 1p 36 region (p73P1, D1S2694, D1S214, D1S2666 and D1S450). LOH was found in at least one of these markers in 27% of tumors. When we established the comparison between tumors with and without LOH and the distribution of the 10 pathologic parameters considered, we observed statistically significant differences in association with higher histologic grade (p = 0.02), more advanced pathological stage (p = 0.02), peritumoral vessel involvement (p = 0.04) and poorly differentiated carcinomas (p = 0.01), as well as in tumors that concomitantly exhibited lymph node metastases, peritumoral vessel involvement and absence of steroid receptors (p = 0.02). These data suggest that LOH in the p73 region could be pathogenically related to breast cancer and possibly to a poor tumor prognosis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1023/a:1006446709715", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "63"
      }
    ], 
    "name": "Clinicopathological characteristics of breast carcinomas with allelic loss in the p73", 
    "pagination": "17-22", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e6404317183c79379f9cb96faad1c050a63965fce6f90be19059cdf75268ca40"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11079155"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1006446709715"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048332920"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1006446709715", 
      "https://app.dimensions.ai/details/publication/pub.1048332920"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000501.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1023/A:1006446709715"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1006446709715'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1006446709715'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1006446709715'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1006446709715'


 

This table displays all metadata directly associated to this object as RDF triples.

305 TRIPLES      21 PREDICATES      78 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1006446709715 schema:about N104956a138be41f7b18cd4b0357bc7cb
2 N14f3109bc3ba41af82ede106cee95cc6
3 N1c0c15b43d3b40ad83f052a740e9fc56
4 N1f3b62556c56439683cb36c62ed6a834
5 N47a2f4c3ded44cdbafdd018f2ec2f508
6 N5a70c898c00c40b7b83de30264caac81
7 N5aac4fcc44f548dd8ab85e80a750aedc
8 N5c4eb2f67e3649969f424e679a0f1662
9 N6bbcce29aaca486fa428364c43daae41
10 N7034808c07704acf9dbd5b20b9665c87
11 N76c24aac0f094a98ad9da13cdba756f0
12 N83a779a096a449df98f23e8efb67a204
13 Nb9dff75cc12d4c29893717121a94a15e
14 Nbeeb0c9edc7a4f389358aff9b9fbd5c3
15 Nd09509dc84ac422f8a096b8d10d2945f
16 Nd0ce5bfa4b934269b0d14317d1a43345
17 Ndc5576e71cd24d23ad25cdbee845309d
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author N4f1ed9e6a91c4b5d9bd5776635b15d0d
21 schema:citation sg:pub.10.1038/38298
22 sg:pub.10.1038/sj.bjc.6690234
23 sg:pub.10.1038/sj.onc.1202390
24 https://app.dimensions.ai/details/publication/pub.1074481984
25 https://app.dimensions.ai/details/publication/pub.1074488154
26 https://app.dimensions.ai/details/publication/pub.1074494999
27 https://app.dimensions.ai/details/publication/pub.1074496212
28 https://app.dimensions.ai/details/publication/pub.1079007915
29 https://app.dimensions.ai/details/publication/pub.1082475897
30 https://app.dimensions.ai/details/publication/pub.1083187481
31 https://app.dimensions.ai/details/publication/pub.1083226558
32 https://app.dimensions.ai/details/publication/pub.1083241017
33 https://app.dimensions.ai/details/publication/pub.1083276283
34 https://app.dimensions.ai/details/publication/pub.1083353318
35 https://app.dimensions.ai/details/publication/pub.1083376155
36 https://doi.org/10.1002/(sici)1097-0142(19980115)82:2<323::aid-cncr11>3.0.co;2-0
37 https://doi.org/10.1002/(sici)1097-0215(19961021)69:5<381::aid-ijc5>3.0.co;2-1
38 https://doi.org/10.1002/(sici)1097-0215(19981109)78:4<437::aid-ijc8>3.0.co;2-v
39 https://doi.org/10.1002/(sici)1097-0215(19990621)84:3<321::aid-ijc21>3.0.co;2-s
40 https://doi.org/10.1002/(sici)1098-2264(199608)16:4<211::aid-gcc1>3.0.co;2-0
41 https://doi.org/10.1002/(sici)1098-2264(199903)24:3<255::aid-gcc11>3.0.co;2-2
42 https://doi.org/10.1002/(sici)1098-2264(199908)25:4<354::aid-gcc7>3.0.co;2-o
43 https://doi.org/10.1002/1097-0142(19941015)74:8<2281::aid-cncr2820740812>3.0.co;2-i
44 https://doi.org/10.1002/gcc.2870050406
45 https://doi.org/10.1002/gcc.2870140402
46 https://doi.org/10.1006/abio.1993.1379
47 https://doi.org/10.1016/0304-419x(94)90009-4
48 https://doi.org/10.1016/s0092-8674(00)80540-1
49 https://doi.org/10.1016/s1097-2765(00)80275-0
50 https://doi.org/10.1053/ejso.1998.0626
51 https://doi.org/10.1128/mcb.19.2.1438
52 https://doi.org/10.3892/ijo.13.2.319
53 schema:datePublished 2000-09
54 schema:datePublishedReg 2000-09-01
55 schema:description p73, a new member of the p53 family, has been mapped to chromosome 1p 36, a region where loss of heterozygosity (LOH) is frequently observed in primary human tumors. Allelic loss studies involving the 1p arm in breast carcinomas offer rates ranging from 13% to 75%, depending on the genetic interval being studied. We investigated LOH in an intragenic microsatellite marker, and those centromerically flanking the p73 gene, at 1p 36, and their correlations with patient age and 10 pathologic parameters in a series of 193 breast carcinomas. The LOH analysis was performed by amplifying DNA by PCR, using the five markers of the 1p 36 region (p73P1, D1S2694, D1S214, D1S2666 and D1S450). LOH was found in at least one of these markers in 27% of tumors. When we established the comparison between tumors with and without LOH and the distribution of the 10 pathologic parameters considered, we observed statistically significant differences in association with higher histologic grade (p = 0.02), more advanced pathological stage (p = 0.02), peritumoral vessel involvement (p = 0.04) and poorly differentiated carcinomas (p = 0.01), as well as in tumors that concomitantly exhibited lymph node metastases, peritumoral vessel involvement and absence of steroid receptors (p = 0.02). These data suggest that LOH in the p73 region could be pathogenically related to breast cancer and possibly to a poor tumor prognosis.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree false
59 schema:isPartOf N53db6f45b907495289d961a3b6fc20ba
60 Ne0c583fb8bae470cae6860b026d1e28c
61 sg:journal.1092777
62 schema:name Clinicopathological characteristics of breast carcinomas with allelic loss in the p73
63 schema:pagination 17-22
64 schema:productId N05addc55a6e64eb38694c178b3566438
65 N2794e143abe24702b46c66927fb477e8
66 N476f91dcb9f147bb9a9347c8f53f1fc8
67 N9137c48edecb4d3f8bce9bdf0492a17e
68 Ne94b1859b10d4c0b99509e89f88207ec
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048332920
70 https://doi.org/10.1023/a:1006446709715
71 schema:sdDatePublished 2019-04-10T22:29
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N23ac16c4e25e4b3c971c800fd35d467f
74 schema:url http://link.springer.com/10.1023/A:1006446709715
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N05addc55a6e64eb38694c178b3566438 schema:name doi
79 schema:value 10.1023/a:1006446709715
80 rdf:type schema:PropertyValue
81 N0ef67e17a5e44f07ad1d1a658ec459fc schema:name Departments of Medical Oncology Pathology, Madrid, Spain
82 rdf:type schema:Organization
83 N104956a138be41f7b18cd4b0357bc7cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Gene Expression Regulation, Neoplastic
85 rdf:type schema:DefinedTerm
86 N14f3109bc3ba41af82ede106cee95cc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Loss of Heterozygosity
88 rdf:type schema:DefinedTerm
89 N1c0c15b43d3b40ad83f052a740e9fc56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Adult
91 rdf:type schema:DefinedTerm
92 N1f3b62556c56439683cb36c62ed6a834 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Microsatellite Repeats
94 rdf:type schema:DefinedTerm
95 N23ac16c4e25e4b3c971c800fd35d467f schema:name Springer Nature - SN SciGraph project
96 rdf:type schema:Organization
97 N2794e143abe24702b46c66927fb477e8 schema:name readcube_id
98 schema:value e6404317183c79379f9cb96faad1c050a63965fce6f90be19059cdf75268ca40
99 rdf:type schema:PropertyValue
100 N2a55027c36f14d7e9b8138503d815c1b rdf:first sg:person.01263634032.37
101 rdf:rest N7292e15ce0fa404894104824701f2317
102 N476f91dcb9f147bb9a9347c8f53f1fc8 schema:name nlm_unique_id
103 schema:value 8111104
104 rdf:type schema:PropertyValue
105 N47a2f4c3ded44cdbafdd018f2ec2f508 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Nuclear Proteins
107 rdf:type schema:DefinedTerm
108 N4e55ce9594d941d59da503d8fadeb316 schema:name Departments of Medical Oncology Pathology, Madrid, Spain
109 rdf:type schema:Organization
110 N4f1ed9e6a91c4b5d9bd5776635b15d0d rdf:first sg:person.01166154641.35
111 rdf:rest N5bb241b26c4047dfae970841860b403e
112 N53db6f45b907495289d961a3b6fc20ba schema:issueNumber 1
113 rdf:type schema:PublicationIssue
114 N565c43492459408c8b253131da67ef62 schema:name Departments of Medical Oncology Pathology, Madrid, Spain
115 rdf:type schema:Organization
116 N5a70c898c00c40b7b83de30264caac81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Tumor Suppressor Proteins
118 rdf:type schema:DefinedTerm
119 N5aac4fcc44f548dd8ab85e80a750aedc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Carcinoma
121 rdf:type schema:DefinedTerm
122 N5bb241b26c4047dfae970841860b403e rdf:first sg:person.0734126226.03
123 rdf:rest N8e228160c2234e0da5482cdb0015973e
124 N5c4eb2f67e3649969f424e679a0f1662 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Tumor Protein p73
126 rdf:type schema:DefinedTerm
127 N6bbcce29aaca486fa428364c43daae41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name DNA-Binding Proteins
129 rdf:type schema:DefinedTerm
130 N7034808c07704acf9dbd5b20b9665c87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Polymerase Chain Reaction
132 rdf:type schema:DefinedTerm
133 N7292e15ce0fa404894104824701f2317 rdf:first sg:person.0726612567.62
134 rdf:rest Na6a47888d62a4dfab8747a7e47d4daaa
135 N76c24aac0f094a98ad9da13cdba756f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Female
137 rdf:type schema:DefinedTerm
138 N7991c74b45554cf2b4acf847a16c6181 schema:name Departments of Medical Oncology Pathology, Madrid, Spain
139 rdf:type schema:Organization
140 N83a779a096a449df98f23e8efb67a204 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Prognosis
142 rdf:type schema:DefinedTerm
143 N8e228160c2234e0da5482cdb0015973e rdf:first sg:person.01012733370.14
144 rdf:rest Ndf21c4de2d09404dbb515c0a4450774c
145 N9137c48edecb4d3f8bce9bdf0492a17e schema:name pubmed_id
146 schema:value 11079155
147 rdf:type schema:PropertyValue
148 Na3db14379b5047258c6230ecedba7309 schema:name Departments of Medical Oncology Pathology, Madrid, Spain
149 rdf:type schema:Organization
150 Na6a47888d62a4dfab8747a7e47d4daaa rdf:first sg:person.01314474117.33
151 rdf:rest Nff894fbdfff746cb83be3a8c1643dc82
152 Nb13400082a294bd4ba09589d7042c662 rdf:first sg:person.01064017117.57
153 rdf:rest Nbe5b75468e614bbcbe3f8613a1f75281
154 Nb79d488087b14bbdb7cea214e970b137 schema:name Departments of Medical Oncology Pathology, Madrid, Spain
155 rdf:type schema:Organization
156 Nb9dff75cc12d4c29893717121a94a15e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Breast Neoplasms
158 rdf:type schema:DefinedTerm
159 Nbe5b75468e614bbcbe3f8613a1f75281 rdf:first sg:person.01307647221.52
160 rdf:rest N2a55027c36f14d7e9b8138503d815c1b
161 Nbeeb0c9edc7a4f389358aff9b9fbd5c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Chromosomes, Human, Pair 1
163 rdf:type schema:DefinedTerm
164 Nbf11bc3f933a4f3295cfc6a307055d84 schema:name Departments of Medical Oncology Pathology, Madrid, Spain
165 rdf:type schema:Organization
166 Nd09509dc84ac422f8a096b8d10d2945f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Humans
168 rdf:type schema:DefinedTerm
169 Nd0c96ba44ed94a07ad156fd0803807ee schema:name Department of Pathology, Hospital Santa Cristina, Madrid, Spain
170 rdf:type schema:Organization
171 Nd0ce5bfa4b934269b0d14317d1a43345 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Genes, Tumor Suppressor
173 rdf:type schema:DefinedTerm
174 Ndc5576e71cd24d23ad25cdbee845309d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name DNA, Neoplasm
176 rdf:type schema:DefinedTerm
177 Nddb64d3fa1cb479cb8b41d6e4393fb93 schema:name Departments of Medical Oncology Pathology, Madrid, Spain
178 rdf:type schema:Organization
179 Ndf21c4de2d09404dbb515c0a4450774c rdf:first sg:person.014645712342.91
180 rdf:rest Nb13400082a294bd4ba09589d7042c662
181 Ne0c583fb8bae470cae6860b026d1e28c schema:volumeNumber 63
182 rdf:type schema:PublicationVolume
183 Ne94b1859b10d4c0b99509e89f88207ec schema:name dimensions_id
184 schema:value pub.1048332920
185 rdf:type schema:PropertyValue
186 Nff894fbdfff746cb83be3a8c1643dc82 rdf:first sg:person.01263153010.07
187 rdf:rest rdf:nil
188 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
189 schema:name Medical and Health Sciences
190 rdf:type schema:DefinedTerm
191 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
192 schema:name Oncology and Carcinogenesis
193 rdf:type schema:DefinedTerm
194 sg:journal.1092777 schema:issn 0167-6806
195 1573-7217
196 schema:name Breast Cancer Research and Treatment
197 rdf:type schema:Periodical
198 sg:person.01012733370.14 schema:affiliation Na3db14379b5047258c6230ecedba7309
199 schema:familyName Silva
200 schema:givenName Jose M.
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012733370.14
202 rdf:type schema:Person
203 sg:person.01064017117.57 schema:affiliation N565c43492459408c8b253131da67ef62
204 schema:familyName Miralles
205 schema:givenName Celia
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064017117.57
207 rdf:type schema:Person
208 sg:person.01166154641.35 schema:affiliation N0ef67e17a5e44f07ad1d1a658ec459fc
209 schema:familyName Dominguez
210 schema:givenName Gemma
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166154641.35
212 rdf:type schema:Person
213 sg:person.01263153010.07 schema:affiliation N7991c74b45554cf2b4acf847a16c6181
214 schema:familyName Bonilla
215 schema:givenName Felix
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263153010.07
217 rdf:type schema:Person
218 sg:person.01263634032.37 schema:affiliation Nd0c96ba44ed94a07ad156fd0803807ee
219 schema:familyName Jareño
220 schema:givenName Eugenia
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263634032.37
222 rdf:type schema:Person
223 sg:person.01307647221.52 schema:affiliation https://www.grid.ac/institutes/grid.73221.35
224 schema:familyName Rodriguez
225 schema:givenName Oscar
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307647221.52
227 rdf:type schema:Person
228 sg:person.01314474117.33 schema:affiliation Nbf11bc3f933a4f3295cfc6a307055d84
229 schema:familyName España
230 schema:givenName Pilar
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314474117.33
232 rdf:type schema:Person
233 sg:person.014645712342.91 schema:affiliation Nb79d488087b14bbdb7cea214e970b137
234 schema:familyName Garcia
235 schema:givenName Jose M.
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014645712342.91
237 rdf:type schema:Person
238 sg:person.0726612567.62 schema:affiliation Nddb64d3fa1cb479cb8b41d6e4393fb93
239 schema:familyName Provencio
240 schema:givenName Mariano
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726612567.62
242 rdf:type schema:Person
243 sg:person.0734126226.03 schema:affiliation N4e55ce9594d941d59da503d8fadeb316
244 schema:familyName Silva
245 schema:givenName Javier
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734126226.03
247 rdf:type schema:Person
248 sg:pub.10.1038/38298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030867943
249 https://doi.org/10.1038/38298
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/sj.bjc.6690234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040576854
252 https://doi.org/10.1038/sj.bjc.6690234
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/sj.onc.1202390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046360162
255 https://doi.org/10.1038/sj.onc.1202390
256 rdf:type schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1074481984 schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1074488154 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1074494999 schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1074496212 schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1079007915 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1082475897 schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1083187481 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1083226558 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1083241017 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1083276283 schema:CreativeWork
267 https://app.dimensions.ai/details/publication/pub.1083353318 schema:CreativeWork
268 https://app.dimensions.ai/details/publication/pub.1083376155 schema:CreativeWork
269 https://doi.org/10.1002/(sici)1097-0142(19980115)82:2<323::aid-cncr11>3.0.co;2-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007170711
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1002/(sici)1097-0215(19961021)69:5<381::aid-ijc5>3.0.co;2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043353251
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1002/(sici)1097-0215(19981109)78:4<437::aid-ijc8>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1002349998
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1002/(sici)1097-0215(19990621)84:3<321::aid-ijc21>3.0.co;2-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1045130149
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1002/(sici)1098-2264(199608)16:4<211::aid-gcc1>3.0.co;2-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040432805
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1002/(sici)1098-2264(199903)24:3<255::aid-gcc11>3.0.co;2-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024198773
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1002/(sici)1098-2264(199908)25:4<354::aid-gcc7>3.0.co;2-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1036907990
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1002/1097-0142(19941015)74:8<2281::aid-cncr2820740812>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1019485637
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1002/gcc.2870050406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028326004
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1002/gcc.2870140402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047391050
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1006/abio.1993.1379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048662652
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/0304-419x(94)90009-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009946715
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/s0092-8674(00)80540-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041015753
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s1097-2765(00)80275-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024825914
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1053/ejso.1998.0626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047021691
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1128/mcb.19.2.1438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024112852
300 rdf:type schema:CreativeWork
301 https://doi.org/10.3892/ijo.13.2.319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071510763
302 rdf:type schema:CreativeWork
303 https://www.grid.ac/institutes/grid.73221.35 schema:alternateName Hospital Universitario Puerta de Hierro Majadahonda
304 schema:name Pathology, Clinica Puerta de Hierro, Madrid, Spain
305 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...