Preliminary Studies on Hepatic Carnitine Palmitoyltransferase in Dairy Cattle with or without Fatty Liver View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-12

AUTHORS

H. Mizutani, T. Sako, Y. Toyoda, T. Kawabata, N. Urumuhang, H. Koyama, S. Motoyoshi

ABSTRACT

The hepatic mitochondrial carnitine palmitoyltransferase (CPT) activity was measured by fluorimetric assay in dairy cows with or without fatty liver. CPT activities in 13 lactating cattle and in 6 non-lactating cows were 304.4±86.6 μmol CoA/min per g protein and 169.3±84.8 μmol CoA/min per g protein, respectively. This difference was significant (<0.05). CPT activities in early lactation (0–110 days after calving), mid-lactation (111–220 days after calving) and late lactation (over 220 days after calving) were 278.9±68.0, 312.4±124.1 and 320±59.3 μmol CoA/min per g protein, respectively. There was no significant difference between the values at different stages of lactation. The CPT activity in 10 lactating cows with fatty liver unrelated to calving was 201.3±80.0 μmol CoA/min per g protein. CPT activity in 10 cattle with fatty liver was significantly lower than that in normal lactating cattle. Based on these findings, clinical fatty liver unrelated to calving appears to be associated with a decrease in hepatic CPT activity. More... »

PAGES

475-480

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1006358222037

DOI

http://dx.doi.org/10.1023/a:1006358222037

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030848950

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10672964


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