Allelic loss of the PTEN region (10q23) in breast carcinomas of poor pathophenotype View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-10

AUTHORS

Jose M. Garcia, Jose M. Silva, Gemma Dominguez, Rocio Gonzalez, Antonia Navarro, Luis Carretero, Mariano Provencio, Pilar España, Felix Bonilla

ABSTRACT

Loss of heterozygosity (LOH) in loci of the 10q23 region that harbor the PTEN gene and mutations in the sequence of this gene have been found in several primary human tumors including breast carcinomas, suggesting that this gene could be implicated in their pathogenesis. We investigated allelic losses in microsatellites of the 10q23 region, and their correlations with nine pathologic parameters in 105 breast carcinomas. The LOH analysis was performed by amplifying DNA by PCR, using five markers of the 10q23 region (D10S1687, D10S541, D10S2491, D10S583 and D10S571). LOH in at least one marker of the PTEN region was found in 29.5% of tumors. The statistical comparison between carcinomas with and without LOH in terms of the pathologic parameters showed significant differences in age (p = 0.03), lymph node metastases (p = 0.02), and higher histological grade (p = 0.02); a trend toward significance was found for progesterone receptors (p = 0.05). LOH in an individual marker and statistically significant relationships to tumor characteristics were observed at locus D10S541 for lymph node metastases (p = 0.04), at D10S2491 (intragenic to the PTEN gene) for lymph node metastases (p = 0.02), and at D10S583 for progesterone receptors (p = 0.01) and for high grade (p = 0.03). These results suggest the PTEN gene, or other genes of the 10q23 region, could be functionally related to breast cancer, probably influencing the development of histological features associated with poor prognosis. More... »

PAGES

237-243

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1006273516976

DOI

http://dx.doi.org/10.1023/a:1006273516976

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028638751

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10617300


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 10", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Loss of Heterozygosity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microsatellite Repeats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoric Monoester Hydrolases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Progesterone", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Puerta de Hierro Majadahonda", 
          "id": "https://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Departments of Medical Oncology, and Pathology, Clinica Puerta de Hierro, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garcia", 
        "givenName": "Jose M.", 
        "id": "sg:person.014645712342.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014645712342.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Puerta de Hierro Majadahonda", 
          "id": "https://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Departments of Medical Oncology, and Pathology, Clinica Puerta de Hierro, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Silva", 
        "givenName": "Jose M.", 
        "id": "sg:person.01012733370.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012733370.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Puerta de Hierro Majadahonda", 
          "id": "https://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Departments of Medical Oncology, and Pathology, Clinica Puerta de Hierro, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dominguez", 
        "givenName": "Gemma", 
        "id": "sg:person.01166154641.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166154641.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Puerta de Hierro Majadahonda", 
          "id": "https://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Departments of Medical Oncology, and Pathology, Clinica Puerta de Hierro, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonzalez", 
        "givenName": "Rocio", 
        "id": "sg:person.01273636062.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273636062.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Puerta de Hierro Majadahonda", 
          "id": "https://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Pathology, Clinica Puerta de Hierro, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Navarro", 
        "givenName": "Antonia", 
        "id": "sg:person.01057437314.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057437314.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital General Universitario Gregorio Mara\u00f1\u00f3n", 
          "id": "https://www.grid.ac/institutes/grid.410526.4", 
          "name": [
            "Department of Pathology, Hospital Gregorio Mara\u00f1on, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carretero", 
        "givenName": "Luis", 
        "id": "sg:person.0631316016.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631316016.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Puerta de Hierro Majadahonda", 
          "id": "https://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Departments of Medical Oncology, and Pathology, Clinica Puerta de Hierro, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Provencio", 
        "givenName": "Mariano", 
        "id": "sg:person.0726612567.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726612567.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Puerta de Hierro Majadahonda", 
          "id": "https://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Departments of Medical Oncology, and Pathology, Clinica Puerta de Hierro, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Espa\u00f1a", 
        "givenName": "Pilar", 
        "id": "sg:person.01314474117.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314474117.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Puerta de Hierro Majadahonda", 
          "id": "https://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Departments of Medical Oncology, and Pathology, Clinica Puerta de Hierro, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonilla", 
        "givenName": "Felix", 
        "id": "sg:person.01263153010.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263153010.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bjc.1996.234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005822696", 
          "https://doi.org/10.1038/bjc.1996.234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005822696", 
          "https://doi.org/10.1038/bjc.1996.234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0597-64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006875378", 
          "https://doi.org/10.1038/ng0597-64"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-419x(94)90009-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009946715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-419x(94)90009-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009946715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.275.5308.1943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014605015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0897-333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018236210", 
          "https://doi.org/10.1038/ng0897-333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2264(199802)21:2<166::aid-gcc13>3.0.co;2-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018991410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021643760", 
          "https://doi.org/10.1038/bjc.1996.597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021643760", 
          "https://doi.org/10.1038/bjc.1996.597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004390050723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022655456", 
          "https://doi.org/10.1007/s004390050723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004390050723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022655456", 
          "https://doi.org/10.1007/s004390050723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1097-143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027604943", 
          "https://doi.org/10.1038/ng1097-143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029860130", 
          "https://doi.org/10.1038/sj.onc.1202081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029860130", 
          "https://doi.org/10.1038/sj.onc.1202081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201855", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033383108", 
          "https://doi.org/10.1038/sj.onc.1201855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201855", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033383108", 
          "https://doi.org/10.1038/sj.onc.1201855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/1235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033843315", 
          "https://doi.org/10.1038/1235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/1235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033843315", 
          "https://doi.org/10.1038/1235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.2870140402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047391050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0497-356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048219802", 
          "https://doi.org/10.1038/ng0497-356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0497-356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048219802", 
          "https://doi.org/10.1038/ng0497-356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abio.1993.1379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048662652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(96)90707-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050589194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051610015", 
          "https://doi.org/10.1038/sj.onc.1201940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051610015", 
          "https://doi.org/10.1038/sj.onc.1201940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/301607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058609220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/301639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058609251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.280.5369.1614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062561345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082424520", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082505772", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082937238", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083143223", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083143224", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083151244", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083159026", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083159027", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083167101", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083167108", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083173464", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083182811", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083187481", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083202724", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083226558", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083350333", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083366801", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-10", 
    "datePublishedReg": "1999-10-01", 
    "description": "Loss of heterozygosity (LOH) in loci of the 10q23 region that harbor the PTEN gene and mutations in the sequence of this gene have been found in several primary human tumors including breast carcinomas, suggesting that this gene could be implicated in their pathogenesis. We investigated allelic losses in microsatellites of the 10q23 region, and their correlations with nine pathologic parameters in 105 breast carcinomas. The LOH analysis was performed by amplifying DNA by PCR, using five markers of the 10q23 region (D10S1687, D10S541, D10S2491, D10S583 and D10S571). LOH in at least one marker of the PTEN region was found in 29.5% of tumors. The statistical comparison between carcinomas with and without LOH in terms of the pathologic parameters showed significant differences in age (p = 0.03), lymph node metastases (p = 0.02), and higher histological grade (p = 0.02); a trend toward significance was found for progesterone receptors (p = 0.05). LOH in an individual marker and statistically significant relationships to tumor characteristics were observed at locus D10S541 for lymph node metastases (p = 0.04), at D10S2491 (intragenic to the PTEN gene) for lymph node metastases (p = 0.02), and at D10S583 for progesterone receptors (p = 0.01) and for high grade (p = 0.03). These results suggest the PTEN gene, or other genes of the 10q23 region, could be functionally related to breast cancer, probably influencing the development of histological features associated with poor prognosis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1023/a:1006273516976", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "57"
      }
    ], 
    "name": "Allelic loss of the PTEN region (10q23) in breast carcinomas of poor pathophenotype", 
    "pagination": "237-243", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "886d08d23eb1db952ba57154fffc73ec4e28cf4b53f163f973f6af0972aac38b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10617300"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1006273516976"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028638751"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1006273516976", 
      "https://app.dimensions.ai/details/publication/pub.1028638751"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000500.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1023/A:1006273516976"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1006273516976'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1006273516976'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1006273516976'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1006273516976'


 

This table displays all metadata directly associated to this object as RDF triples.

282 TRIPLES      21 PREDICATES      78 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1006273516976 schema:about N113f360f0b854f15ada2811186366793
2 N3d8e4a819baf411693eaea11cf4590a7
3 N495bed6c74e74a089a3451a0462a11ef
4 N4c3f3e67a06e4920875e44a30f523382
5 N5357265c2eb14d928392317b9d051d9c
6 N6340c54db825458fa2c2a6de7bcca9da
7 N8697fb163bfc4b50b71c921aeb6474ab
8 N9f9f2e7edf284ca99e78c9e05e894d2f
9 Nca1c1354b45d49bd90589121d012e313
10 Nd49213fe91c54b3a813033cdca4c83be
11 Nebcf63bf81b3478bb6342cdc6b1eda81
12 Nfb866b35f943462c8b6c6963498adb05
13 anzsrc-for:11
14 anzsrc-for:1112
15 schema:author N7e6afd2b1cb2458d95d23db22d4ba459
16 schema:citation sg:pub.10.1007/s004390050723
17 sg:pub.10.1038/1235
18 sg:pub.10.1038/bjc.1996.234
19 sg:pub.10.1038/bjc.1996.597
20 sg:pub.10.1038/ng0497-356
21 sg:pub.10.1038/ng0597-64
22 sg:pub.10.1038/ng0897-333
23 sg:pub.10.1038/ng1097-143
24 sg:pub.10.1038/sj.onc.1201855
25 sg:pub.10.1038/sj.onc.1201940
26 sg:pub.10.1038/sj.onc.1202081
27 https://app.dimensions.ai/details/publication/pub.1082424520
28 https://app.dimensions.ai/details/publication/pub.1082505772
29 https://app.dimensions.ai/details/publication/pub.1082937238
30 https://app.dimensions.ai/details/publication/pub.1083143223
31 https://app.dimensions.ai/details/publication/pub.1083143224
32 https://app.dimensions.ai/details/publication/pub.1083151244
33 https://app.dimensions.ai/details/publication/pub.1083159026
34 https://app.dimensions.ai/details/publication/pub.1083159027
35 https://app.dimensions.ai/details/publication/pub.1083167101
36 https://app.dimensions.ai/details/publication/pub.1083167108
37 https://app.dimensions.ai/details/publication/pub.1083173464
38 https://app.dimensions.ai/details/publication/pub.1083182811
39 https://app.dimensions.ai/details/publication/pub.1083187481
40 https://app.dimensions.ai/details/publication/pub.1083202724
41 https://app.dimensions.ai/details/publication/pub.1083226558
42 https://app.dimensions.ai/details/publication/pub.1083350333
43 https://app.dimensions.ai/details/publication/pub.1083366801
44 https://doi.org/10.1002/(sici)1098-2264(199802)21:2<166::aid-gcc13>3.0.co;2-p
45 https://doi.org/10.1002/gcc.2870140402
46 https://doi.org/10.1006/abio.1993.1379
47 https://doi.org/10.1016/0304-419x(94)90009-4
48 https://doi.org/10.1016/s0140-6736(96)90707-2
49 https://doi.org/10.1086/301607
50 https://doi.org/10.1086/301639
51 https://doi.org/10.1126/science.275.5308.1943
52 https://doi.org/10.1126/science.280.5369.1614
53 schema:datePublished 1999-10
54 schema:datePublishedReg 1999-10-01
55 schema:description Loss of heterozygosity (LOH) in loci of the 10q23 region that harbor the PTEN gene and mutations in the sequence of this gene have been found in several primary human tumors including breast carcinomas, suggesting that this gene could be implicated in their pathogenesis. We investigated allelic losses in microsatellites of the 10q23 region, and their correlations with nine pathologic parameters in 105 breast carcinomas. The LOH analysis was performed by amplifying DNA by PCR, using five markers of the 10q23 region (D10S1687, D10S541, D10S2491, D10S583 and D10S571). LOH in at least one marker of the PTEN region was found in 29.5% of tumors. The statistical comparison between carcinomas with and without LOH in terms of the pathologic parameters showed significant differences in age (p = 0.03), lymph node metastases (p = 0.02), and higher histological grade (p = 0.02); a trend toward significance was found for progesterone receptors (p = 0.05). LOH in an individual marker and statistically significant relationships to tumor characteristics were observed at locus D10S541 for lymph node metastases (p = 0.04), at D10S2491 (intragenic to the PTEN gene) for lymph node metastases (p = 0.02), and at D10S583 for progesterone receptors (p = 0.01) and for high grade (p = 0.03). These results suggest the PTEN gene, or other genes of the 10q23 region, could be functionally related to breast cancer, probably influencing the development of histological features associated with poor prognosis.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree false
59 schema:isPartOf N9b72d1fe75db478c85b53a57c9a13e54
60 Nbadc7921ea0642abbd890d6799f99d27
61 sg:journal.1092777
62 schema:name Allelic loss of the PTEN region (10q23) in breast carcinomas of poor pathophenotype
63 schema:pagination 237-243
64 schema:productId N01e5b46da71047bd8a1d5449fb170471
65 N0279fa3ce62d45aabb159961f9dcdaba
66 N7bb4942cfbae4b24930560256e058354
67 Nc2443875cf854a22a3a7d73803728319
68 Ne33eedddc39940f59658341f723063b7
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028638751
70 https://doi.org/10.1023/a:1006273516976
71 schema:sdDatePublished 2019-04-10T19:06
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N5a562f93c37347b1851c1e3ec36f4a64
74 schema:url http://link.springer.com/10.1023/A:1006273516976
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N01e5b46da71047bd8a1d5449fb170471 schema:name readcube_id
79 schema:value 886d08d23eb1db952ba57154fffc73ec4e28cf4b53f163f973f6af0972aac38b
80 rdf:type schema:PropertyValue
81 N0279fa3ce62d45aabb159961f9dcdaba schema:name doi
82 schema:value 10.1023/a:1006273516976
83 rdf:type schema:PropertyValue
84 N113f360f0b854f15ada2811186366793 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Humans
86 rdf:type schema:DefinedTerm
87 N1726eb88a7114ad9875e27970e92f9e9 rdf:first sg:person.01273636062.13
88 rdf:rest Ne8c14a99a9e84826b70bbea18175d617
89 N32e1643651064588a44ec792ab27c89d rdf:first sg:person.0726612567.62
90 rdf:rest Ncf4384474dcf4b2692f0648da5fadabc
91 N3d8e4a819baf411693eaea11cf4590a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Loss of Heterozygosity
93 rdf:type schema:DefinedTerm
94 N495bed6c74e74a089a3451a0462a11ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Phosphoric Monoester Hydrolases
96 rdf:type schema:DefinedTerm
97 N4c3f3e67a06e4920875e44a30f523382 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Female
99 rdf:type schema:DefinedTerm
100 N5357265c2eb14d928392317b9d051d9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Chromosomes, Human, Pair 10
102 rdf:type schema:DefinedTerm
103 N5a562f93c37347b1851c1e3ec36f4a64 schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 N6340c54db825458fa2c2a6de7bcca9da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Receptors, Progesterone
107 rdf:type schema:DefinedTerm
108 N7bb4942cfbae4b24930560256e058354 schema:name dimensions_id
109 schema:value pub.1028638751
110 rdf:type schema:PropertyValue
111 N7e6afd2b1cb2458d95d23db22d4ba459 rdf:first sg:person.014645712342.91
112 rdf:rest Nfb06f636627944fc924e703c686cf39f
113 N8697fb163bfc4b50b71c921aeb6474ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Microsatellite Repeats
115 rdf:type schema:DefinedTerm
116 N8b8d98c70e8441608f403e3a69847443 rdf:first sg:person.0631316016.89
117 rdf:rest N32e1643651064588a44ec792ab27c89d
118 N9b72d1fe75db478c85b53a57c9a13e54 schema:issueNumber 3
119 rdf:type schema:PublicationIssue
120 N9f9f2e7edf284ca99e78c9e05e894d2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Polymerase Chain Reaction
122 rdf:type schema:DefinedTerm
123 Nbadc7921ea0642abbd890d6799f99d27 schema:volumeNumber 57
124 rdf:type schema:PublicationVolume
125 Nc237520d595e49678e398dbd9bd064fc rdf:first sg:person.01166154641.35
126 rdf:rest N1726eb88a7114ad9875e27970e92f9e9
127 Nc2443875cf854a22a3a7d73803728319 schema:name nlm_unique_id
128 schema:value 8111104
129 rdf:type schema:PropertyValue
130 Nca1c1354b45d49bd90589121d012e313 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Lymphatic Metastasis
132 rdf:type schema:DefinedTerm
133 Ncf4384474dcf4b2692f0648da5fadabc rdf:first sg:person.01314474117.33
134 rdf:rest Nd2918ceea47247928c51306eeb2c5deb
135 Nd2918ceea47247928c51306eeb2c5deb rdf:first sg:person.01263153010.07
136 rdf:rest rdf:nil
137 Nd49213fe91c54b3a813033cdca4c83be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Neoplasm Invasiveness
139 rdf:type schema:DefinedTerm
140 Ne33eedddc39940f59658341f723063b7 schema:name pubmed_id
141 schema:value 10617300
142 rdf:type schema:PropertyValue
143 Ne8c14a99a9e84826b70bbea18175d617 rdf:first sg:person.01057437314.48
144 rdf:rest N8b8d98c70e8441608f403e3a69847443
145 Nebcf63bf81b3478bb6342cdc6b1eda81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Prognosis
147 rdf:type schema:DefinedTerm
148 Nfb06f636627944fc924e703c686cf39f rdf:first sg:person.01012733370.14
149 rdf:rest Nc237520d595e49678e398dbd9bd064fc
150 Nfb866b35f943462c8b6c6963498adb05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Breast Neoplasms
152 rdf:type schema:DefinedTerm
153 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
154 schema:name Medical and Health Sciences
155 rdf:type schema:DefinedTerm
156 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
157 schema:name Oncology and Carcinogenesis
158 rdf:type schema:DefinedTerm
159 sg:journal.1092777 schema:issn 0167-6806
160 1573-7217
161 schema:name Breast Cancer Research and Treatment
162 rdf:type schema:Periodical
163 sg:person.01012733370.14 schema:affiliation https://www.grid.ac/institutes/grid.73221.35
164 schema:familyName Silva
165 schema:givenName Jose M.
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012733370.14
167 rdf:type schema:Person
168 sg:person.01057437314.48 schema:affiliation https://www.grid.ac/institutes/grid.73221.35
169 schema:familyName Navarro
170 schema:givenName Antonia
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057437314.48
172 rdf:type schema:Person
173 sg:person.01166154641.35 schema:affiliation https://www.grid.ac/institutes/grid.73221.35
174 schema:familyName Dominguez
175 schema:givenName Gemma
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166154641.35
177 rdf:type schema:Person
178 sg:person.01263153010.07 schema:affiliation https://www.grid.ac/institutes/grid.73221.35
179 schema:familyName Bonilla
180 schema:givenName Felix
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263153010.07
182 rdf:type schema:Person
183 sg:person.01273636062.13 schema:affiliation https://www.grid.ac/institutes/grid.73221.35
184 schema:familyName Gonzalez
185 schema:givenName Rocio
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273636062.13
187 rdf:type schema:Person
188 sg:person.01314474117.33 schema:affiliation https://www.grid.ac/institutes/grid.73221.35
189 schema:familyName España
190 schema:givenName Pilar
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314474117.33
192 rdf:type schema:Person
193 sg:person.014645712342.91 schema:affiliation https://www.grid.ac/institutes/grid.73221.35
194 schema:familyName Garcia
195 schema:givenName Jose M.
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014645712342.91
197 rdf:type schema:Person
198 sg:person.0631316016.89 schema:affiliation https://www.grid.ac/institutes/grid.410526.4
199 schema:familyName Carretero
200 schema:givenName Luis
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631316016.89
202 rdf:type schema:Person
203 sg:person.0726612567.62 schema:affiliation https://www.grid.ac/institutes/grid.73221.35
204 schema:familyName Provencio
205 schema:givenName Mariano
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726612567.62
207 rdf:type schema:Person
208 sg:pub.10.1007/s004390050723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022655456
209 https://doi.org/10.1007/s004390050723
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/1235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033843315
212 https://doi.org/10.1038/1235
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/bjc.1996.234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005822696
215 https://doi.org/10.1038/bjc.1996.234
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/bjc.1996.597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021643760
218 https://doi.org/10.1038/bjc.1996.597
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/ng0497-356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048219802
221 https://doi.org/10.1038/ng0497-356
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/ng0597-64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006875378
224 https://doi.org/10.1038/ng0597-64
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/ng0897-333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018236210
227 https://doi.org/10.1038/ng0897-333
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/ng1097-143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027604943
230 https://doi.org/10.1038/ng1097-143
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/sj.onc.1201855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033383108
233 https://doi.org/10.1038/sj.onc.1201855
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/sj.onc.1201940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051610015
236 https://doi.org/10.1038/sj.onc.1201940
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/sj.onc.1202081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029860130
239 https://doi.org/10.1038/sj.onc.1202081
240 rdf:type schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1082424520 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1082505772 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1082937238 schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1083143223 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1083143224 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1083151244 schema:CreativeWork
247 https://app.dimensions.ai/details/publication/pub.1083159026 schema:CreativeWork
248 https://app.dimensions.ai/details/publication/pub.1083159027 schema:CreativeWork
249 https://app.dimensions.ai/details/publication/pub.1083167101 schema:CreativeWork
250 https://app.dimensions.ai/details/publication/pub.1083167108 schema:CreativeWork
251 https://app.dimensions.ai/details/publication/pub.1083173464 schema:CreativeWork
252 https://app.dimensions.ai/details/publication/pub.1083182811 schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1083187481 schema:CreativeWork
254 https://app.dimensions.ai/details/publication/pub.1083202724 schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1083226558 schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1083350333 schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1083366801 schema:CreativeWork
258 https://doi.org/10.1002/(sici)1098-2264(199802)21:2<166::aid-gcc13>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1018991410
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1002/gcc.2870140402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047391050
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1006/abio.1993.1379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048662652
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/0304-419x(94)90009-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009946715
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/s0140-6736(96)90707-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050589194
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1086/301607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058609220
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1086/301639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058609251
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1126/science.275.5308.1943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014605015
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1126/science.280.5369.1614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062561345
275 rdf:type schema:CreativeWork
276 https://www.grid.ac/institutes/grid.410526.4 schema:alternateName Hospital General Universitario Gregorio Marañón
277 schema:name Department of Pathology, Hospital Gregorio Marañon, Madrid, Spain
278 rdf:type schema:Organization
279 https://www.grid.ac/institutes/grid.73221.35 schema:alternateName Hospital Universitario Puerta de Hierro Majadahonda
280 schema:name Departments of Medical Oncology, and Pathology, Clinica Puerta de Hierro, Madrid, Spain
281 Pathology, Clinica Puerta de Hierro, Madrid, Spain
282 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...