Pathobiologic identification of two distinct breast carcinoma subsets with diverging clinical behaviors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-05

AUTHORS

Sylvie Ménard, Patrizia Casalini, Gorana Tomasic, Silvana Pilotti, Natale Cascinelli, Rosaria Bufalino, Franco Perrone, Chiara Longhi, Franco Rilke, M. Ines Colnaghi

ABSTRACT

Many different pathological and biological variables which characterize breast carcinomas have been found to be associated. The aim of this work was to analyze the complex relationship among these parameters. The pathologic, biologic, and clinical characteristics of a series of primary breast carcinomas from 676 patients were retrospectively investigated. Multiple correspondence analysis of 13 factors revealed clustering of eight pathobiologic variables, that is histologic grade, necrosis, lymphoid infiltration, number of mitoses, c-erbB-2 overexpression, p53, progesterone receptor, and bcl2 expression. An index for each tumor calculated on the basis of these eight factors served to distinguish two different tumor phenotypes, designated A and B. Phenotype A is represented by tumors sharing most of the biologic features of normal breast tissues: indeed, these tumors are characterized by a relatively high degree of differentiation, low proliferation, no necrosis or leukocyte infiltration, and no gene alterations. By contrast, phenotype B is quite divergent from the normal tissue because of its poor differentiation, high proliferation, frequent gene alterations and evidence of a host immune reaction. As regards the disease progression, these two subsets showed marked differences: phenotype A tumors had a low recurrence rate per year that remained constant over time and affected more frequently elderly patients, whereas group B tumors showed high aggressivity in the first years after surgery followed by a low long-term recurrence rate and were more frequently seen in younger patients. These data suggest that breast carcinoma consists of two different subsets that can be identified on the basis of pathobiologic features. More... »

PAGES

167-175

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1006262324959

DOI

http://dx.doi.org/10.1023/a:1006262324959

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047763314

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10481944


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cathepsin D", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Italy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocyte Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Menopause", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitotic Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Necrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-bcl-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, ErbB-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Progesterone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Experimental Oncology, Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00e9nard", 
        "givenName": "Sylvie", 
        "id": "sg:person.0713166741.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713166741.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Experimental Oncology, Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Casalini", 
        "givenName": "Patrizia", 
        "id": "sg:person.0606656153.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606656153.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Anatomical Pathology and Cytology, Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tomasic", 
        "givenName": "Gorana", 
        "id": "sg:person.0665460265.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665460265.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Anatomical Pathology and Cytology, Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pilotti", 
        "givenName": "Silvana", 
        "id": "sg:person.01104224641.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104224641.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cascinelli", 
        "givenName": "Natale", 
        "id": "sg:person.0113226134.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0113226134.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Surgical Oncology B, Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bufalino", 
        "givenName": "Rosaria", 
        "id": "sg:person.01316066622.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316066622.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Controlled Clinical Trials Office, Istituto Nazionale per lo studio e la cura dei tumori, Napoli, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perrone", 
        "givenName": "Franco", 
        "id": "sg:person.01221627613.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221627613.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Experimental Oncology, Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Longhi", 
        "givenName": "Chiara", 
        "id": "sg:person.0710470412.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710470412.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rilke", 
        "givenName": "Franco", 
        "id": "sg:person.01047000616.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047000616.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Experimental Oncology, Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Colnaghi", 
        "givenName": "M. Ines", 
        "id": "sg:person.01117757224.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117757224.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01807163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004222897", 
          "https://doi.org/10.1007/bf01807163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01807163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004222897", 
          "https://doi.org/10.1007/bf01807163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199206253262607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005975324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00666054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011422922", 
          "https://doi.org/10.1007/bf00666054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00666054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011422922", 
          "https://doi.org/10.1007/bf00666054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00666587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017803487", 
          "https://doi.org/10.1007/bf00666587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00666587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017803487", 
          "https://doi.org/10.1007/bf00666587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1977.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027080276", 
          "https://doi.org/10.1038/bjc.1977.1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1977.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027080276", 
          "https://doi.org/10.1038/bjc.1977.1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1995.tb00213.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029126224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1995.tb00213.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029126224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcp/100.3.213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034240952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0952-7915(93)90125-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036358943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00133466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037190510", 
          "https://doi.org/10.1007/bf00133466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00133466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037190510", 
          "https://doi.org/10.1007/bf00133466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0009-9260(05)82937-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039665335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1711680404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051457357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1711680404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051457357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910490109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052888607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01621459.1987.10478446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058303423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/85.12.965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059817996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/86.7.499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059819176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3798106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062621480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1992.10.5.696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077003809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082544903", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082558391", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082667552", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1996.14.1.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082858586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1996.14.10.2702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082983625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1996.14.10.2843", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082983643"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-05", 
    "datePublishedReg": "1999-05-01", 
    "description": "Many different pathological and biological variables which characterize breast carcinomas have been found to be associated. The aim of this work was to analyze the complex relationship among these parameters. The pathologic, biologic, and clinical characteristics of a series of primary breast carcinomas from 676 patients were retrospectively investigated. Multiple correspondence analysis of 13 factors revealed clustering of eight pathobiologic variables, that is histologic grade, necrosis, lymphoid infiltration, number of mitoses, c-erbB-2 overexpression, p53, progesterone receptor, and bcl2 expression. An index for each tumor calculated on the basis of these eight factors served to distinguish two different tumor phenotypes, designated A and B. Phenotype A is represented by tumors sharing most of the biologic features of normal breast tissues: indeed, these tumors are characterized by a relatively high degree of differentiation, low proliferation, no necrosis or leukocyte infiltration, and no gene alterations. By contrast, phenotype B is quite divergent from the normal tissue because of its poor differentiation, high proliferation, frequent gene alterations and evidence of a host immune reaction. As regards the disease progression, these two subsets showed marked differences: phenotype A tumors had a low recurrence rate per year that remained constant over time and affected more frequently elderly patients, whereas group B tumors showed high aggressivity in the first years after surgery followed by a low long-term recurrence rate and were more frequently seen in younger patients. These data suggest that breast carcinoma consists of two different subsets that can be identified on the basis of pathobiologic features.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1023/a:1006262324959", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "55"
      }
    ], 
    "name": "Pathobiologic identification of two distinct breast carcinoma subsets with diverging clinical behaviors", 
    "pagination": "167-175", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e3882992c8a0c2b099961b25ee9f750d350dc9f21ecf56896679711d8d84e3be"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10481944"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1006262324959"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047763314"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1006262324959", 
      "https://app.dimensions.ai/details/publication/pub.1047763314"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000501.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1023/A:1006262324959"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1006262324959'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1006262324959'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1006262324959'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1006262324959'


 

This table displays all metadata directly associated to this object as RDF triples.

333 TRIPLES      21 PREDICATES      80 URIs      49 LITERALS      37 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1006262324959 schema:about N0683e18184db4577bfa56198bda0aff6
2 N136753ce61bb4bca8a98c56681eed698
3 N152ec509ed5f4ffcba1625c35929beb2
4 N165e246fd92b499c99bd3220373fb332
5 N18b26782cf194bcca7676bdb592b4f15
6 N23fbdf660ab5441586c08b721a821367
7 N2c2776a66c684be4939e7f08e7700496
8 N3a715e9c26d04d6786e096a10be088a9
9 N3e1b80edd07d454abd5d947804d81cc9
10 N3e232ed76f694d26bf5d839e33dbb36e
11 N4d543654c9cb46b3aa6102a7b3856b0f
12 N4f11e70a3f1c46b98c6727526f47492e
13 N601605d768c84b26a1dd445a142ecb4d
14 N6447febc95474018885e31ce07d217fa
15 N9092161173194d839c3c0f23118cc722
16 N919d112801ec46eab459ff342f6f0b6d
17 Na29d363ac8474c0c8e58c7f80d1a00ee
18 Naffdf0aa95ef446c9cda64420fc6513f
19 Nb15f99471dbd49da8e869a127f0d798d
20 Nbbf99736da1d45e584585e3fd23189e4
21 Nc540f337f4734bd59762eea3907b439e
22 Nc561325b4bb44997875ee5feaf8e69af
23 Nc6c3069506f746318775537cc1698be2
24 Ncfd3b70b56ac4e9aaf1845b7fbdab05f
25 Nd6987b0698ed4d23b9e336680a00acd7
26 Ne5980c5378a74c918dc51e396bdb2f86
27 Ne958856e0f334672b89a21957c2d0e85
28 Necbdd9b144724080a00a1f56ad512c70
29 anzsrc-for:11
30 anzsrc-for:1112
31 schema:author Ne286ab53d50c477eb96cd6a9ca1e8198
32 schema:citation sg:pub.10.1007/bf00133466
33 sg:pub.10.1007/bf00666054
34 sg:pub.10.1007/bf00666587
35 sg:pub.10.1007/bf01807163
36 sg:pub.10.1038/bjc.1977.1
37 https://app.dimensions.ai/details/publication/pub.1082544903
38 https://app.dimensions.ai/details/publication/pub.1082558391
39 https://app.dimensions.ai/details/publication/pub.1082667552
40 https://doi.org/10.1002/ijc.2910490109
41 https://doi.org/10.1002/path.1711680404
42 https://doi.org/10.1016/0952-7915(93)90125-c
43 https://doi.org/10.1016/s0009-9260(05)82937-x
44 https://doi.org/10.1056/nejm199206253262607
45 https://doi.org/10.1080/01621459.1987.10478446
46 https://doi.org/10.1093/ajcp/100.3.213
47 https://doi.org/10.1093/jnci/85.12.965
48 https://doi.org/10.1093/jnci/86.7.499
49 https://doi.org/10.1111/j.1365-2559.1995.tb00213.x
50 https://doi.org/10.1126/science.3798106
51 https://doi.org/10.1200/jco.1992.10.5.696
52 https://doi.org/10.1200/jco.1996.14.1.85
53 https://doi.org/10.1200/jco.1996.14.10.2702
54 https://doi.org/10.1200/jco.1996.14.10.2843
55 schema:datePublished 1999-05
56 schema:datePublishedReg 1999-05-01
57 schema:description Many different pathological and biological variables which characterize breast carcinomas have been found to be associated. The aim of this work was to analyze the complex relationship among these parameters. The pathologic, biologic, and clinical characteristics of a series of primary breast carcinomas from 676 patients were retrospectively investigated. Multiple correspondence analysis of 13 factors revealed clustering of eight pathobiologic variables, that is histologic grade, necrosis, lymphoid infiltration, number of mitoses, c-erbB-2 overexpression, p53, progesterone receptor, and bcl2 expression. An index for each tumor calculated on the basis of these eight factors served to distinguish two different tumor phenotypes, designated A and B. Phenotype A is represented by tumors sharing most of the biologic features of normal breast tissues: indeed, these tumors are characterized by a relatively high degree of differentiation, low proliferation, no necrosis or leukocyte infiltration, and no gene alterations. By contrast, phenotype B is quite divergent from the normal tissue because of its poor differentiation, high proliferation, frequent gene alterations and evidence of a host immune reaction. As regards the disease progression, these two subsets showed marked differences: phenotype A tumors had a low recurrence rate per year that remained constant over time and affected more frequently elderly patients, whereas group B tumors showed high aggressivity in the first years after surgery followed by a low long-term recurrence rate and were more frequently seen in younger patients. These data suggest that breast carcinoma consists of two different subsets that can be identified on the basis of pathobiologic features.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree false
61 schema:isPartOf N1870283bed6148f799dc51e914972b1a
62 Nf1ca17ffb73b42f8b01f57dd2025a514
63 sg:journal.1092777
64 schema:name Pathobiologic identification of two distinct breast carcinoma subsets with diverging clinical behaviors
65 schema:pagination 167-175
66 schema:productId N0b42fad4e24140b49c2ef149877f1db1
67 N108913af02ba4598a621a6100e9e2249
68 N1a399e003cdc4163a3cbefd7f9a25570
69 Nd2ccd10a4d6c46dfab8e989c09cd8922
70 Ne8e55b225c9d471b9af57b0bed065328
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047763314
72 https://doi.org/10.1023/a:1006262324959
73 schema:sdDatePublished 2019-04-10T14:07
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher N0c1f6a87240d485ab52f2e22cc4fd3e5
76 schema:url http://link.springer.com/10.1023/A:1006262324959
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N0683e18184db4577bfa56198bda0aff6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Combined Modality Therapy
82 rdf:type schema:DefinedTerm
83 N0b42fad4e24140b49c2ef149877f1db1 schema:name nlm_unique_id
84 schema:value 8111104
85 rdf:type schema:PropertyValue
86 N0c1f6a87240d485ab52f2e22cc4fd3e5 schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 N0cdad08af69a4ac8a78de6ef8074dec4 rdf:first sg:person.01047000616.68
89 rdf:rest Nef9150c2a3c847ecaee8191dbb0c907f
90 N108913af02ba4598a621a6100e9e2249 schema:name pubmed_id
91 schema:value 10481944
92 rdf:type schema:PropertyValue
93 N136753ce61bb4bca8a98c56681eed698 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Middle Aged
95 rdf:type schema:DefinedTerm
96 N13d7651876f340eb86b7a31bcd79bec7 schema:name Department of Experimental Oncology, Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan
97 rdf:type schema:Organization
98 N152ec509ed5f4ffcba1625c35929beb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Humans
100 rdf:type schema:DefinedTerm
101 N165e246fd92b499c99bd3220373fb332 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Disease Progression
103 rdf:type schema:DefinedTerm
104 N1870283bed6148f799dc51e914972b1a schema:volumeNumber 55
105 rdf:type schema:PublicationVolume
106 N18b26782cf194bcca7676bdb592b4f15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Biomarkers, Tumor
108 rdf:type schema:DefinedTerm
109 N1a399e003cdc4163a3cbefd7f9a25570 schema:name doi
110 schema:value 10.1023/a:1006262324959
111 rdf:type schema:PropertyValue
112 N23fbdf660ab5441586c08b721a821367 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Aged
114 rdf:type schema:DefinedTerm
115 N2c2776a66c684be4939e7f08e7700496 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Menopause
117 rdf:type schema:DefinedTerm
118 N3a715e9c26d04d6786e096a10be088a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Chemotherapy, Adjuvant
120 rdf:type schema:DefinedTerm
121 N3d1c91d113214700926e01dca9d38729 rdf:first sg:person.0710470412.81
122 rdf:rest N0cdad08af69a4ac8a78de6ef8074dec4
123 N3e1b80edd07d454abd5d947804d81cc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Risk Factors
125 rdf:type schema:DefinedTerm
126 N3e232ed76f694d26bf5d839e33dbb36e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Cell Division
128 rdf:type schema:DefinedTerm
129 N3e55880f13134bdb9599dcabc6317973 schema:name Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan
130 rdf:type schema:Organization
131 N420b31443cab40a0acef8d22c1af6157 rdf:first sg:person.01221627613.25
132 rdf:rest N3d1c91d113214700926e01dca9d38729
133 N4b5e2a26ef064390acdcc8d7eb74a41d rdf:first sg:person.0606656153.43
134 rdf:rest N88c66288e0004d5cbb102e2f8d3f09a0
135 N4d543654c9cb46b3aa6102a7b3856b0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cell Differentiation
137 rdf:type schema:DefinedTerm
138 N4ef0ad30479b4614a439f8b61d851737 rdf:first sg:person.01316066622.03
139 rdf:rest N420b31443cab40a0acef8d22c1af6157
140 N4f11e70a3f1c46b98c6727526f47492e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Retrospective Studies
142 rdf:type schema:DefinedTerm
143 N507a926083094be2b7c7aae70b8c3e16 schema:name Department of Experimental Oncology, Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan
144 rdf:type schema:Organization
145 N514587ed180f4220877d93038f06bd7b schema:name Division of Anatomical Pathology and Cytology, Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan
146 rdf:type schema:Organization
147 N601605d768c84b26a1dd445a142ecb4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Adult
149 rdf:type schema:DefinedTerm
150 N6447febc95474018885e31ce07d217fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Italy
152 rdf:type schema:DefinedTerm
153 N751dfbe20a184fecb05c947f37286bc9 schema:name Division of Surgical Oncology B, Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan
154 rdf:type schema:Organization
155 N7e68a5750df347adb395c249ebd2f18b rdf:first sg:person.01104224641.20
156 rdf:rest Nff847bd1020840cbbde782c88ad4ced8
157 N8215232dd00244038bf1417f146769bd schema:name Department of Experimental Oncology, Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan
158 rdf:type schema:Organization
159 N88c66288e0004d5cbb102e2f8d3f09a0 rdf:first sg:person.0665460265.17
160 rdf:rest N7e68a5750df347adb395c249ebd2f18b
161 N9092161173194d839c3c0f23118cc722 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Carcinoma
163 rdf:type schema:DefinedTerm
164 N919d112801ec46eab459ff342f6f0b6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Lymphatic Metastasis
166 rdf:type schema:DefinedTerm
167 Na29d363ac8474c0c8e58c7f80d1a00ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Female
169 rdf:type schema:DefinedTerm
170 Naffdf0aa95ef446c9cda64420fc6513f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Breast Neoplasms
172 rdf:type schema:DefinedTerm
173 Nb15f99471dbd49da8e869a127f0d798d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Mitotic Index
175 rdf:type schema:DefinedTerm
176 Nb22bf6bf2a514604871bef07d59475c2 schema:name Department of Experimental Oncology, Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan
177 rdf:type schema:Organization
178 Nbbf99736da1d45e584585e3fd23189e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Phenotype
180 rdf:type schema:DefinedTerm
181 Nbe90a6286f914d95a11615e52a9f2128 schema:name Division of Anatomical Pathology and Cytology, Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan
182 rdf:type schema:Organization
183 Nc540f337f4734bd59762eea3907b439e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Cathepsin D
185 rdf:type schema:DefinedTerm
186 Nc561325b4bb44997875ee5feaf8e69af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Necrosis
188 rdf:type schema:DefinedTerm
189 Nc6c3069506f746318775537cc1698be2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Tumor Suppressor Protein p53
191 rdf:type schema:DefinedTerm
192 Ncfd3b70b56ac4e9aaf1845b7fbdab05f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Neoplasm Proteins
194 rdf:type schema:DefinedTerm
195 Nd2ccd10a4d6c46dfab8e989c09cd8922 schema:name readcube_id
196 schema:value e3882992c8a0c2b099961b25ee9f750d350dc9f21ecf56896679711d8d84e3be
197 rdf:type schema:PropertyValue
198 Nd6987b0698ed4d23b9e336680a00acd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Proto-Oncogene Proteins c-bcl-2
200 rdf:type schema:DefinedTerm
201 Ne286ab53d50c477eb96cd6a9ca1e8198 rdf:first sg:person.0713166741.31
202 rdf:rest N4b5e2a26ef064390acdcc8d7eb74a41d
203 Ne577aa915c7e47c0b3100e6a92254b87 schema:name Istituto Nazionale per io Studio e ia Cura dei Tumori, Milan
204 rdf:type schema:Organization
205 Ne5980c5378a74c918dc51e396bdb2f86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Receptors, Progesterone
207 rdf:type schema:DefinedTerm
208 Ne8e55b225c9d471b9af57b0bed065328 schema:name dimensions_id
209 schema:value pub.1047763314
210 rdf:type schema:PropertyValue
211 Ne958856e0f334672b89a21957c2d0e85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Leukocyte Count
213 rdf:type schema:DefinedTerm
214 Necbdd9b144724080a00a1f56ad512c70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Receptor, ErbB-2
216 rdf:type schema:DefinedTerm
217 Nef9150c2a3c847ecaee8191dbb0c907f rdf:first sg:person.01117757224.02
218 rdf:rest rdf:nil
219 Nf1ca17ffb73b42f8b01f57dd2025a514 schema:issueNumber 2
220 rdf:type schema:PublicationIssue
221 Nff847bd1020840cbbde782c88ad4ced8 rdf:first sg:person.0113226134.00
222 rdf:rest N4ef0ad30479b4614a439f8b61d851737
223 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
224 schema:name Medical and Health Sciences
225 rdf:type schema:DefinedTerm
226 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
227 schema:name Oncology and Carcinogenesis
228 rdf:type schema:DefinedTerm
229 sg:journal.1092777 schema:issn 0167-6806
230 1573-7217
231 schema:name Breast Cancer Research and Treatment
232 rdf:type schema:Periodical
233 sg:person.01047000616.68 schema:affiliation Ne577aa915c7e47c0b3100e6a92254b87
234 schema:familyName Rilke
235 schema:givenName Franco
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047000616.68
237 rdf:type schema:Person
238 sg:person.01104224641.20 schema:affiliation N514587ed180f4220877d93038f06bd7b
239 schema:familyName Pilotti
240 schema:givenName Silvana
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104224641.20
242 rdf:type schema:Person
243 sg:person.01117757224.02 schema:affiliation N8215232dd00244038bf1417f146769bd
244 schema:familyName Colnaghi
245 schema:givenName M. Ines
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117757224.02
247 rdf:type schema:Person
248 sg:person.0113226134.00 schema:affiliation N3e55880f13134bdb9599dcabc6317973
249 schema:familyName Cascinelli
250 schema:givenName Natale
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0113226134.00
252 rdf:type schema:Person
253 sg:person.01221627613.25 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
254 schema:familyName Perrone
255 schema:givenName Franco
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221627613.25
257 rdf:type schema:Person
258 sg:person.01316066622.03 schema:affiliation N751dfbe20a184fecb05c947f37286bc9
259 schema:familyName Bufalino
260 schema:givenName Rosaria
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316066622.03
262 rdf:type schema:Person
263 sg:person.0606656153.43 schema:affiliation Nb22bf6bf2a514604871bef07d59475c2
264 schema:familyName Casalini
265 schema:givenName Patrizia
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606656153.43
267 rdf:type schema:Person
268 sg:person.0665460265.17 schema:affiliation Nbe90a6286f914d95a11615e52a9f2128
269 schema:familyName Tomasic
270 schema:givenName Gorana
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665460265.17
272 rdf:type schema:Person
273 sg:person.0710470412.81 schema:affiliation N13d7651876f340eb86b7a31bcd79bec7
274 schema:familyName Longhi
275 schema:givenName Chiara
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710470412.81
277 rdf:type schema:Person
278 sg:person.0713166741.31 schema:affiliation N507a926083094be2b7c7aae70b8c3e16
279 schema:familyName Ménard
280 schema:givenName Sylvie
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713166741.31
282 rdf:type schema:Person
283 sg:pub.10.1007/bf00133466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037190510
284 https://doi.org/10.1007/bf00133466
285 rdf:type schema:CreativeWork
286 sg:pub.10.1007/bf00666054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011422922
287 https://doi.org/10.1007/bf00666054
288 rdf:type schema:CreativeWork
289 sg:pub.10.1007/bf00666587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017803487
290 https://doi.org/10.1007/bf00666587
291 rdf:type schema:CreativeWork
292 sg:pub.10.1007/bf01807163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004222897
293 https://doi.org/10.1007/bf01807163
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/bjc.1977.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027080276
296 https://doi.org/10.1038/bjc.1977.1
297 rdf:type schema:CreativeWork
298 https://app.dimensions.ai/details/publication/pub.1082544903 schema:CreativeWork
299 https://app.dimensions.ai/details/publication/pub.1082558391 schema:CreativeWork
300 https://app.dimensions.ai/details/publication/pub.1082667552 schema:CreativeWork
301 https://doi.org/10.1002/ijc.2910490109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052888607
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1002/path.1711680404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051457357
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/0952-7915(93)90125-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1036358943
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/s0009-9260(05)82937-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039665335
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1056/nejm199206253262607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005975324
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1080/01621459.1987.10478446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058303423
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1093/ajcp/100.3.213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034240952
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1093/jnci/85.12.965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059817996
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1093/jnci/86.7.499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059819176
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1111/j.1365-2559.1995.tb00213.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029126224
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1126/science.3798106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062621480
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1200/jco.1992.10.5.696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077003809
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1200/jco.1996.14.1.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082858586
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1200/jco.1996.14.10.2702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082983625
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1200/jco.1996.14.10.2843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082983643
330 rdf:type schema:CreativeWork
331 https://www.grid.ac/institutes/grid.417893.0 schema:alternateName Istituto Nazionale dei Tumori
332 schema:name Controlled Clinical Trials Office, Istituto Nazionale per lo studio e la cura dei tumori, Napoli, Italy
333 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...