Optimal use of the 131-I-metaiodobenzylguanidine and cisplatin combination in advanced neuroblastoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-01

AUTHORS

Renato Mastrangelo, Assunta Tornesello, Anna Lasorella, Antonio Iavarone, Stefano Mastrangelo, Riccardo Riccardi, Luca Diociaiuti, Vittoria Rufini, Andrea Pession, Luigi Troncone

ABSTRACT

Neuroblastoma (NB), a childhood radiosensitive tumor, is very aggressive and malignant, in its disseminated form, despite very intensive chemotherapy, prognosis continues to be dismal. Owing to its capacity to concentrate in NB lesions, large doses of 131-I-MIBG, have given very encouraging therapeutic results in patients resistant to conventional therapy as well as at diagnosis. We recently reported the first attempt in combination therapy (CO-TH) using 131-I-MIBG and cisplatin. This new form of CO-TH appears very effective in obtaining a rapid and excellent response in relapsed patients. In this report, we describe the results of further experience with CO-TH in disseminated NB. We have attempted to verify to what extent interaction between the effects of the two agents may produce therapeutic benefit, and we have sought the optimization of CO-TH use. Three stage IV NB patients were treated with CO-TH. The following treatment schedule, was planned: day 1, cisplatin 50 mg/m3 i.v. over 6 h; day 2, 131-I-MIBG 100-130 mCi at high specific activity (-1.1 Gbq/mg) i.v. over 6 h followed, a week later, by the same treatment combination. The therapeutic results were encouraging. However, hematological toxicity continued to represent a major limiting factor. In view of the overall effectiveness of CO-TH, at the price of lasting hematological toxicity, it may be indicated as a consolidation regimen some time before conditioning chemotherapy for autologous bone marrow transplantation. More... »

PAGES

153-158

References to SciGraph publications

  • 1983-05. Cellular heterogeneity in tumours in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1023/a:1005770405844

    DOI

    http://dx.doi.org/10.1023/a:1005770405844

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044341612

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9049843


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "3-Iodobenzylguanidine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Combined Chemotherapy Protocols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child, Preschool", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cisplatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Follow-Up Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Iodobenzenes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Staging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neuroblastoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Radionuclide Imaging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tomography, X-Ray Computed", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Catholic University of the Sacred Heart", 
              "id": "https://www.grid.ac/institutes/grid.8142.f", 
              "name": [
                "Division of Pediatric Oncology, Catholic University, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mastrangelo", 
            "givenName": "Renato", 
            "id": "sg:person.01260407352.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260407352.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Catholic University of the Sacred Heart", 
              "id": "https://www.grid.ac/institutes/grid.8142.f", 
              "name": [
                "Division of Pediatric Oncology, Catholic University, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tornesello", 
            "givenName": "Assunta", 
            "id": "sg:person.0717715170.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717715170.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Catholic University of the Sacred Heart", 
              "id": "https://www.grid.ac/institutes/grid.8142.f", 
              "name": [
                "Division of Pediatric Oncology, Catholic University, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lasorella", 
            "givenName": "Anna", 
            "id": "sg:person.01104624007.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104624007.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Catholic University of the Sacred Heart", 
              "id": "https://www.grid.ac/institutes/grid.8142.f", 
              "name": [
                "Division of Pediatric Oncology, Catholic University, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iavarone", 
            "givenName": "Antonio", 
            "id": "sg:person.0743765737.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743765737.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Catholic University of the Sacred Heart", 
              "id": "https://www.grid.ac/institutes/grid.8142.f", 
              "name": [
                "Division of Pediatric Oncology, Catholic University, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mastrangelo", 
            "givenName": "Stefano", 
            "id": "sg:person.01261445672.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261445672.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Catholic University of the Sacred Heart", 
              "id": "https://www.grid.ac/institutes/grid.8142.f", 
              "name": [
                "Division of Pediatric Oncology, Catholic University, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Riccardi", 
            "givenName": "Riccardo", 
            "id": "sg:person.01203447731.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203447731.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Catholic University of the Sacred Heart", 
              "id": "https://www.grid.ac/institutes/grid.8142.f", 
              "name": [
                "Division of Pediatric Oncology, Catholic University, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Diociaiuti", 
            "givenName": "Luca", 
            "id": "sg:person.01366477456.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366477456.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Catholic University of America", 
              "id": "https://www.grid.ac/institutes/grid.39936.36", 
              "name": [
                "Department of Nuclear Medicine, Catholic University, Rome"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rufini", 
            "givenName": "Vittoria", 
            "id": "sg:person.01110666107.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110666107.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Bologna", 
              "id": "https://www.grid.ac/institutes/grid.6292.f", 
              "name": [
                "Clinica Pediatrica, University of Bologna, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pession", 
            "givenName": "Andrea", 
            "id": "sg:person.01071267715.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071267715.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Catholic University of America", 
              "id": "https://www.grid.ac/institutes/grid.39936.36", 
              "name": [
                "Department of Nuclear Medicine, Catholic University, Rome"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Troncone", 
            "givenName": "Luigi", 
            "id": "sg:person.01015071022.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015071022.64"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/0959-8049(95)00048-n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001176988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-8140(88)90044-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003628021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mpo.2950150403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014772951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1983.96", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021543039", 
              "https://doi.org/10.1038/bjc.1983.96"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1983.96", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021543039", 
              "https://doi.org/10.1038/bjc.1983.96"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mpo.2950150417", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023576784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0360-3016(87)90015-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027078984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mpo.2950210604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048693872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00043426-198921000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060298279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00043426-198921000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060298279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00043426-198921000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060298279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077601179", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081707773", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1997-01", 
        "datePublishedReg": "1997-01-01", 
        "description": "Neuroblastoma (NB), a childhood radiosensitive tumor, is very aggressive and malignant, in its disseminated form, despite very intensive chemotherapy, prognosis continues to be dismal. Owing to its capacity to concentrate in NB lesions, large doses of 131-I-MIBG, have given very encouraging therapeutic results in patients resistant to conventional therapy as well as at diagnosis. We recently reported the first attempt in combination therapy (CO-TH) using 131-I-MIBG and cisplatin. This new form of CO-TH appears very effective in obtaining a rapid and excellent response in relapsed patients. In this report, we describe the results of further experience with CO-TH in disseminated NB. We have attempted to verify to what extent interaction between the effects of the two agents may produce therapeutic benefit, and we have sought the optimization of CO-TH use. Three stage IV NB patients were treated with CO-TH. The following treatment schedule, was planned: day 1, cisplatin 50 mg/m3 i.v. over 6 h; day 2, 131-I-MIBG 100-130 mCi at high specific activity (-1.1 Gbq/mg) i.v. over 6 h followed, a week later, by the same treatment combination. The therapeutic results were encouraging. However, hematological toxicity continued to represent a major limiting factor. In view of the overall effectiveness of CO-TH, at the price of lasting hematological toxicity, it may be indicated as a consolidation regimen some time before conditioning chemotherapy for autologous bone marrow transplantation.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1023/a:1005770405844", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1094205", 
            "issn": [
              "0167-594X", 
              "1573-7373"
            ], 
            "name": "Journal of Neuro-Oncology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1-2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "31"
          }
        ], 
        "name": "Optimal use of the 131-I-metaiodobenzylguanidine and cisplatin combination in advanced neuroblastoma", 
        "pagination": "153-158", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d336f27e7f32d9e7779abd62ae78f2a9f63e10c9ad9ec0cc1e845656a1a1fd05"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "9049843"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8309335"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1023/a:1005770405844"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1044341612"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1023/a:1005770405844", 
          "https://app.dimensions.ai/details/publication/pub.1044341612"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T15:56", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000537.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1023%2FA%3A1005770405844"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1005770405844'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1005770405844'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1005770405844'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1005770405844'


     

    This table displays all metadata directly associated to this object as RDF triples.

    227 TRIPLES      21 PREDICATES      54 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1023/a:1005770405844 schema:about N05cc46ab386e4fd2a628050e58f3c685
    2 N31baf7505bd04093aa73402d8b88cb73
    3 N36f2c97dbb0b4021adc7e8ae7866d8ef
    4 N45fbed58de164a90820f313ce672ee97
    5 N52ec81c4ab6d460a8f1c3a00aa0e8cdf
    6 N5dd4f73bc2e8494d8de0da3aae8e43f0
    7 N7598a7e9947640f8956d23c162fff52e
    8 N9e474d11c762490baf31788deafaac57
    9 N9ec01c5ef39d46d8b3e94fff4ba9d5c3
    10 Na153803d21d34a9ea9d3c20e523a6a1b
    11 Nad82d95296fb42799784e4b702b6aa9d
    12 Nb597d7f8b99246fdaee39bcdc6917747
    13 Nc792178e0cdf4f5eab23619ce0c56208
    14 Ncec3263b2c194550b70efacd90a48a74
    15 Ne27c111db21e4f16bbc05adb48b2b5fd
    16 anzsrc-for:11
    17 anzsrc-for:1112
    18 schema:author N1a695c9ce7d14bcd9a3ce19e27255661
    19 schema:citation sg:pub.10.1038/bjc.1983.96
    20 https://app.dimensions.ai/details/publication/pub.1077601179
    21 https://app.dimensions.ai/details/publication/pub.1081707773
    22 https://doi.org/10.1002/mpo.2950150403
    23 https://doi.org/10.1002/mpo.2950150417
    24 https://doi.org/10.1002/mpo.2950210604
    25 https://doi.org/10.1016/0167-8140(88)90044-8
    26 https://doi.org/10.1016/0360-3016(87)90015-0
    27 https://doi.org/10.1016/0959-8049(95)00048-n
    28 https://doi.org/10.1097/00043426-198921000-00007
    29 schema:datePublished 1997-01
    30 schema:datePublishedReg 1997-01-01
    31 schema:description Neuroblastoma (NB), a childhood radiosensitive tumor, is very aggressive and malignant, in its disseminated form, despite very intensive chemotherapy, prognosis continues to be dismal. Owing to its capacity to concentrate in NB lesions, large doses of 131-I-MIBG, have given very encouraging therapeutic results in patients resistant to conventional therapy as well as at diagnosis. We recently reported the first attempt in combination therapy (CO-TH) using 131-I-MIBG and cisplatin. This new form of CO-TH appears very effective in obtaining a rapid and excellent response in relapsed patients. In this report, we describe the results of further experience with CO-TH in disseminated NB. We have attempted to verify to what extent interaction between the effects of the two agents may produce therapeutic benefit, and we have sought the optimization of CO-TH use. Three stage IV NB patients were treated with CO-TH. The following treatment schedule, was planned: day 1, cisplatin 50 mg/m3 i.v. over 6 h; day 2, 131-I-MIBG 100-130 mCi at high specific activity (-1.1 Gbq/mg) i.v. over 6 h followed, a week later, by the same treatment combination. The therapeutic results were encouraging. However, hematological toxicity continued to represent a major limiting factor. In view of the overall effectiveness of CO-TH, at the price of lasting hematological toxicity, it may be indicated as a consolidation regimen some time before conditioning chemotherapy for autologous bone marrow transplantation.
    32 schema:genre research_article
    33 schema:inLanguage en
    34 schema:isAccessibleForFree false
    35 schema:isPartOf N65baa518c7a74755a89b62899e277f64
    36 N71e193f093674b3495fb14b5f5f50195
    37 sg:journal.1094205
    38 schema:name Optimal use of the 131-I-metaiodobenzylguanidine and cisplatin combination in advanced neuroblastoma
    39 schema:pagination 153-158
    40 schema:productId N3b89af1fa41d4e919337d6840f0704dc
    41 N3d1285e8369c4aefbf95e224d7be6cd4
    42 N3e016e0ec674411f94aff5814b00deb4
    43 N478aa68535e140c3a9ddc75feab06fd0
    44 N55094c6651334d70b48d6e56fe75d4f0
    45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044341612
    46 https://doi.org/10.1023/a:1005770405844
    47 schema:sdDatePublished 2019-04-10T15:56
    48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    49 schema:sdPublisher Nbdf47271d3c24ea08bea9bb47e9f8074
    50 schema:url http://link.springer.com/10.1023%2FA%3A1005770405844
    51 sgo:license sg:explorer/license/
    52 sgo:sdDataset articles
    53 rdf:type schema:ScholarlyArticle
    54 N05cc46ab386e4fd2a628050e58f3c685 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    55 schema:name Radionuclide Imaging
    56 rdf:type schema:DefinedTerm
    57 N1a695c9ce7d14bcd9a3ce19e27255661 rdf:first sg:person.01260407352.34
    58 rdf:rest Ne24461be18c245efbd4985a8a6366aec
    59 N2c5c8c67ebe8486a9a904efa86e3cd92 rdf:first sg:person.01203447731.76
    60 rdf:rest Nc8fe0aaa5b35407b94865d7e6ad8b89a
    61 N31baf7505bd04093aa73402d8b88cb73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    62 schema:name Iodobenzenes
    63 rdf:type schema:DefinedTerm
    64 N36f2c97dbb0b4021adc7e8ae7866d8ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    65 schema:name Neoplasm Staging
    66 rdf:type schema:DefinedTerm
    67 N3b89af1fa41d4e919337d6840f0704dc schema:name readcube_id
    68 schema:value d336f27e7f32d9e7779abd62ae78f2a9f63e10c9ad9ec0cc1e845656a1a1fd05
    69 rdf:type schema:PropertyValue
    70 N3d1285e8369c4aefbf95e224d7be6cd4 schema:name pubmed_id
    71 schema:value 9049843
    72 rdf:type schema:PropertyValue
    73 N3e016e0ec674411f94aff5814b00deb4 schema:name doi
    74 schema:value 10.1023/a:1005770405844
    75 rdf:type schema:PropertyValue
    76 N40da1440eafa425cae160c0b7b71b226 rdf:first sg:person.01104624007.32
    77 rdf:rest Ncfd5c4c5100e496aa3f9d248e143d1ed
    78 N45fbed58de164a90820f313ce672ee97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    79 schema:name Humans
    80 rdf:type schema:DefinedTerm
    81 N478aa68535e140c3a9ddc75feab06fd0 schema:name nlm_unique_id
    82 schema:value 8309335
    83 rdf:type schema:PropertyValue
    84 N52ec81c4ab6d460a8f1c3a00aa0e8cdf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    85 schema:name Neuroblastoma
    86 rdf:type schema:DefinedTerm
    87 N55094c6651334d70b48d6e56fe75d4f0 schema:name dimensions_id
    88 schema:value pub.1044341612
    89 rdf:type schema:PropertyValue
    90 N5dd4f73bc2e8494d8de0da3aae8e43f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    91 schema:name Antineoplastic Agents
    92 rdf:type schema:DefinedTerm
    93 N65baa518c7a74755a89b62899e277f64 schema:volumeNumber 31
    94 rdf:type schema:PublicationVolume
    95 N71e193f093674b3495fb14b5f5f50195 schema:issueNumber 1-2
    96 rdf:type schema:PublicationIssue
    97 N7598a7e9947640f8956d23c162fff52e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Tomography, X-Ray Computed
    99 rdf:type schema:DefinedTerm
    100 N9e474d11c762490baf31788deafaac57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Antineoplastic Combined Chemotherapy Protocols
    102 rdf:type schema:DefinedTerm
    103 N9ec01c5ef39d46d8b3e94fff4ba9d5c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Cisplatin
    105 rdf:type schema:DefinedTerm
    106 Na153803d21d34a9ea9d3c20e523a6a1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Male
    108 rdf:type schema:DefinedTerm
    109 Na6194c8e92134e3cb6aed2f5d46a895d rdf:first sg:person.01071267715.93
    110 rdf:rest Nf581f3ce510846339983003210b75a44
    111 Nad82d95296fb42799784e4b702b6aa9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Female
    113 rdf:type schema:DefinedTerm
    114 Nad8cff1fe2eb4a8d9409c37b24ae6063 rdf:first sg:person.01261445672.20
    115 rdf:rest N2c5c8c67ebe8486a9a904efa86e3cd92
    116 Nb597d7f8b99246fdaee39bcdc6917747 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Child
    118 rdf:type schema:DefinedTerm
    119 Nbdf47271d3c24ea08bea9bb47e9f8074 schema:name Springer Nature - SN SciGraph project
    120 rdf:type schema:Organization
    121 Nc792178e0cdf4f5eab23619ce0c56208 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Follow-Up Studies
    123 rdf:type schema:DefinedTerm
    124 Nc8fe0aaa5b35407b94865d7e6ad8b89a rdf:first sg:person.01366477456.23
    125 rdf:rest Nc92921ac0b5346e89c852818174db0bb
    126 Nc92921ac0b5346e89c852818174db0bb rdf:first sg:person.01110666107.79
    127 rdf:rest Na6194c8e92134e3cb6aed2f5d46a895d
    128 Ncec3263b2c194550b70efacd90a48a74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Child, Preschool
    130 rdf:type schema:DefinedTerm
    131 Ncfd5c4c5100e496aa3f9d248e143d1ed rdf:first sg:person.0743765737.26
    132 rdf:rest Nad8cff1fe2eb4a8d9409c37b24ae6063
    133 Ne24461be18c245efbd4985a8a6366aec rdf:first sg:person.0717715170.95
    134 rdf:rest N40da1440eafa425cae160c0b7b71b226
    135 Ne27c111db21e4f16bbc05adb48b2b5fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name 3-Iodobenzylguanidine
    137 rdf:type schema:DefinedTerm
    138 Nf581f3ce510846339983003210b75a44 rdf:first sg:person.01015071022.64
    139 rdf:rest rdf:nil
    140 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    141 schema:name Medical and Health Sciences
    142 rdf:type schema:DefinedTerm
    143 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    144 schema:name Oncology and Carcinogenesis
    145 rdf:type schema:DefinedTerm
    146 sg:journal.1094205 schema:issn 0167-594X
    147 1573-7373
    148 schema:name Journal of Neuro-Oncology
    149 rdf:type schema:Periodical
    150 sg:person.01015071022.64 schema:affiliation https://www.grid.ac/institutes/grid.39936.36
    151 schema:familyName Troncone
    152 schema:givenName Luigi
    153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015071022.64
    154 rdf:type schema:Person
    155 sg:person.01071267715.93 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
    156 schema:familyName Pession
    157 schema:givenName Andrea
    158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071267715.93
    159 rdf:type schema:Person
    160 sg:person.01104624007.32 schema:affiliation https://www.grid.ac/institutes/grid.8142.f
    161 schema:familyName Lasorella
    162 schema:givenName Anna
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104624007.32
    164 rdf:type schema:Person
    165 sg:person.01110666107.79 schema:affiliation https://www.grid.ac/institutes/grid.39936.36
    166 schema:familyName Rufini
    167 schema:givenName Vittoria
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110666107.79
    169 rdf:type schema:Person
    170 sg:person.01203447731.76 schema:affiliation https://www.grid.ac/institutes/grid.8142.f
    171 schema:familyName Riccardi
    172 schema:givenName Riccardo
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203447731.76
    174 rdf:type schema:Person
    175 sg:person.01260407352.34 schema:affiliation https://www.grid.ac/institutes/grid.8142.f
    176 schema:familyName Mastrangelo
    177 schema:givenName Renato
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260407352.34
    179 rdf:type schema:Person
    180 sg:person.01261445672.20 schema:affiliation https://www.grid.ac/institutes/grid.8142.f
    181 schema:familyName Mastrangelo
    182 schema:givenName Stefano
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261445672.20
    184 rdf:type schema:Person
    185 sg:person.01366477456.23 schema:affiliation https://www.grid.ac/institutes/grid.8142.f
    186 schema:familyName Diociaiuti
    187 schema:givenName Luca
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366477456.23
    189 rdf:type schema:Person
    190 sg:person.0717715170.95 schema:affiliation https://www.grid.ac/institutes/grid.8142.f
    191 schema:familyName Tornesello
    192 schema:givenName Assunta
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717715170.95
    194 rdf:type schema:Person
    195 sg:person.0743765737.26 schema:affiliation https://www.grid.ac/institutes/grid.8142.f
    196 schema:familyName Iavarone
    197 schema:givenName Antonio
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743765737.26
    199 rdf:type schema:Person
    200 sg:pub.10.1038/bjc.1983.96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021543039
    201 https://doi.org/10.1038/bjc.1983.96
    202 rdf:type schema:CreativeWork
    203 https://app.dimensions.ai/details/publication/pub.1077601179 schema:CreativeWork
    204 https://app.dimensions.ai/details/publication/pub.1081707773 schema:CreativeWork
    205 https://doi.org/10.1002/mpo.2950150403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014772951
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1002/mpo.2950150417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023576784
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1002/mpo.2950210604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048693872
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1016/0167-8140(88)90044-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003628021
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1016/0360-3016(87)90015-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027078984
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1016/0959-8049(95)00048-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1001176988
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1097/00043426-198921000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060298279
    218 rdf:type schema:CreativeWork
    219 https://www.grid.ac/institutes/grid.39936.36 schema:alternateName Catholic University of America
    220 schema:name Department of Nuclear Medicine, Catholic University, Rome
    221 rdf:type schema:Organization
    222 https://www.grid.ac/institutes/grid.6292.f schema:alternateName University of Bologna
    223 schema:name Clinica Pediatrica, University of Bologna, Italy
    224 rdf:type schema:Organization
    225 https://www.grid.ac/institutes/grid.8142.f schema:alternateName Catholic University of the Sacred Heart
    226 schema:name Division of Pediatric Oncology, Catholic University, Rome, Italy
    227 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...