P-glycoprotein: The intermediate end point of drug response to induction chemotherapy in locally advanced breast cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-01

AUTHORS

Hyun Cheol Chung, Sun Young Rha, Joo Hang Kim, Jae Kyung Roh, Jin Sik Min, Kyung Sik Lee, Byung Soo Kim, Kyi Beom Lee

ABSTRACT

Expression and clinical relevance of p-glycoprotein (p-gp) were evaluated in 31 cases of locally advanced breast cancer and 9 cases involving inflammatory breast cancer after induction chemotherapy. The de novo p-gp expression rate was 26% and increased up to 58% (p = 0.03) with the FAC (5-fluorouracil, adriamycin, cyclophosphamide) regimen. Although more clinically complete responders were found in the secondary p-gp negative group (p = 0.02), this difference was not found in pathological tumor response. Moreover, as the grade of the secondary p-gp expression increased, the chemotherapeutic effect decreased, suggesting an inverse relationship between p-gp expression and drug effect (p = 0.04). When we subgrouped the patients into 4 groups using these two parameters, p-gp negative patients presenting with a high drug effect showed a low recurrence rate (p = 0.05) and marginal survival benefits (p = 0.09) as opposed to patients with a low drug effect. But in p-gp positive groups, the recurrence rate was the same between the two groups regardless of the drug effect. Thus, in the p-gp negative patient with a high drug effect, adjuvant chemotherapy with the same regimen as induction chemotherapy may induce more prognostically favorable results. Therefore, clinical application of the secondary p-gp detection can be used as an intermediate endpoint in evaluating drug response for an induction regimen. More... »

PAGES

65-72

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1005739525196

DOI

http://dx.doi.org/10.1023/a:1005739525196

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035255164

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9116319


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