Enhanced lymphocyte proliferation in patients with adrenoleukodystrophy treated with erucic acid (22:1)-rich triglycerides View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-03

AUTHORS

R. Barmaki Pour, S. Stöckler-Ipsiroglu, D. H. Hunneman, M. Gahr, G. C. Korenke, W. Pabst, F. Hanefeld, A. Peters

ABSTRACT

Lymphocytopenia and depression of natural killer cells have been observed in patients with adrenoleukodystrophy (ALD) treated with glycerol trioleate and glycerol trierucate ('Lorenzo's oil'). To investigate possible alterations of cellular immunoreactivity, we measured lymphocyte proliferation in response to mitogens (PHA, Con A, PWM, OKT3) in 27 patients on treatment and in 14 patients without treatment. In patients on treatment, lymphocyte proliferation in response to the mitogens PHA and Con A was significantly higher than in patients without treatment. Lymphocyte proliferation in patients without treatment was comparable to that of normal control lymphocytes. Additionally, we found increased concentrations of erucic acid, C22:1, in lymphocytes from patients with treatment. The enhanced proliferation of lymphocytes in response to mitogens is an indication of increased reactivity of cellular immunity to unspecific immunological stimuli. Long-term side-effects on cellular immunoreactivity have to be considered in ALD patients treated with Lorenzo's oil. More... »

PAGES

113-119

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1005657530372

DOI

http://dx.doi.org/10.1023/a:1005657530372

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038354655

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10801052


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