Upregulated Cyclooxygenase-2 Inhibits Apoptosis of Human Gastric Epithelial Cells Infected with Helicobacter pylori View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-12

AUTHORS

Jung Mogg Kim, Joo Sung Kim, Hyun Chae Jung, In Sung Song, Chung Yong Kim

ABSTRACT

Helicobacter pylori induces apoptosis and alters the proliferation of gastric mucosal epithelial cells. Cyclooxygenase-2 (COX-2), the inducible form of prostaglandin (PG) synthesis, is known to cause alteration in epithelial cell growth. The goal of this study was to determine whether COX-2 gene expression by H. pylori infection could influence gastric epithelial cell apoptosis. Expression of COX-2 mRNA and proteins was up-regulated in Hs746T gastric epithelial cell lines infected with H. pylori, when assessed by quantitative RT-PCR and western blot. Inhibition of COX-2 expression using NS-398, a specific COX-2 inhibitor, showed a significant increase of gastric epithelial cell apoptosis and caspase-3 activation in Hs746T cells infected with H. pylori. Moreover, the effect of NS-398 on H. pylori-induced apoptosis was reversed by the addition of PGE2. These results suggest that up-regulated COX-2 expression by H. pylori infection can inhibit apoptosis of gastric epithelial cells. More... »

PAGES

2436-2443

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1005611613542

DOI

http://dx.doi.org/10.1023/a:1005611613542

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032505853

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11258572


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclooxygenase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclooxygenase 2 Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclooxygenase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dinoprostone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Bacterial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Helicobacter Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Helicobacter pylori", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Isoenzymes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitrobenzenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostaglandin-Endoperoxide Synthases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sulfonamides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Microbiology and Institute of Biomedical Science, Hanyang University College of Medicine, Seoul, Korea", 
            "Department of Internal Medicine, the Liver Research Institute, The Institutes for Endemic Diseases and the Medical Research Center, Seoul National University College of Medicine, Seoul, Korea", 
            "Clinical Research Institute, Seoul National University Hospital, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jung Mogg", 
        "id": "sg:person.01064772272.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064772272.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Microbiology and Institute of Biomedical Science, Hanyang University College of Medicine, Seoul, Korea", 
            "Department of Internal Medicine, the Liver Research Institute, The Institutes for Endemic Diseases and the Medical Research Center, Seoul National University College of Medicine, Seoul, Korea", 
            "Clinical Research Institute, Seoul National University Hospital, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Joo Sung", 
        "id": "sg:person.07514633567.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07514633567.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Microbiology and Institute of Biomedical Science, Hanyang University College of Medicine, Seoul, Korea", 
            "Department of Internal Medicine, the Liver Research Institute, The Institutes for Endemic Diseases and the Medical Research Center, Seoul National University College of Medicine, Seoul, Korea", 
            "Clinical Research Institute, Seoul National University Hospital, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jung", 
        "givenName": "Hyun Chae", 
        "id": "sg:person.01230372236.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230372236.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Microbiology and Institute of Biomedical Science, Hanyang University College of Medicine, Seoul, Korea", 
            "Department of Internal Medicine, the Liver Research Institute, The Institutes for Endemic Diseases and the Medical Research Center, Seoul National University College of Medicine, Seoul, Korea", 
            "Clinical Research Institute, Seoul National University Hospital, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "In Sung", 
        "id": "sg:person.01001342362.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001342362.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Microbiology and Institute of Biomedical Science, Hanyang University College of Medicine, Seoul, Korea", 
            "Department of Internal Medicine, the Liver Research Institute, The Institutes for Endemic Diseases and the Medical Research Center, Seoul National University College of Medicine, Seoul, Korea", 
            "Clinical Research Institute, Seoul National University Hospital, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Chung Yong", 
        "id": "sg:person.0714777622.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714777622.22"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1084/jem.181.5.1661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003282493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.44.28560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004151120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abbi.1995.1130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006192533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci2466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006596958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.187.10.1659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007136353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90127-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007200098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.1999.876_e.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007599619", 
          "https://doi.org/10.1111/j.1572-0241.1999.876_e.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.1999.876_e.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007599619", 
          "https://doi.org/10.1111/j.1572-0241.1999.876_e.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.38.4.498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013844049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2776(08)60430-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014523809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365519709060035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023160932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci119535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025162614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(97)70003-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030172768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1746.1997.tb00469.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030319399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci119557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031458391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-6980(94)90074-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032269393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/003655200750024515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033788438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(97)99999-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034415961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81433-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034592591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1005461427250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037640828", 
          "https://doi.org/10.1023/a:1005461427250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.7.3336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038658027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/89.12.863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047466918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.1997.v113.pm9322504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048674935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.1994.tb00274.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050028200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9098(199811)69:3<168::aid-jso9>3.0.co;2-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051628264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.272.1.65", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054157307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2567.1998.00646.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056735829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2567.1998.00646.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056735829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074474679", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074494550", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082473553", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082489147", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082636332", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083071650", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083356316", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-12", 
    "datePublishedReg": "2000-12-01", 
    "description": "Helicobacter pylori induces apoptosis and alters the proliferation of gastric mucosal epithelial cells. Cyclooxygenase-2 (COX-2), the inducible form of prostaglandin (PG) synthesis, is known to cause alteration in epithelial cell growth. The goal of this study was to determine whether COX-2 gene expression by H. pylori infection could influence gastric epithelial cell apoptosis. Expression of COX-2 mRNA and proteins was up-regulated in Hs746T gastric epithelial cell lines infected with H. pylori, when assessed by quantitative RT-PCR and western blot. Inhibition of COX-2 expression using NS-398, a specific COX-2 inhibitor, showed a significant increase of gastric epithelial cell apoptosis and caspase-3 activation in Hs746T cells infected with H. pylori. Moreover, the effect of NS-398 on H. pylori-induced apoptosis was reversed by the addition of PGE2. These results suggest that up-regulated COX-2 expression by H. pylori infection can inhibit apoptosis of gastric epithelial cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1023/a:1005611613542", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018525", 
        "issn": [
          "0163-2116", 
          "1573-2568"
        ], 
        "name": "Digestive Diseases and Sciences", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "45"
      }
    ], 
    "name": "Upregulated Cyclooxygenase-2 Inhibits Apoptosis of Human Gastric Epithelial Cells Infected with Helicobacter pylori", 
    "pagination": "2436-2443", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9adad055d3cc8008d529fb377936b24e31f9da84ad0e98adb5889a5108bdc1f9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11258572"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7902782"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1005611613542"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032505853"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1005611613542", 
      "https://app.dimensions.ai/details/publication/pub.1032505853"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000500.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1023/A:1005611613542"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1005611613542'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1005611613542'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1005611613542'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1005611613542'


 

This table displays all metadata directly associated to this object as RDF triples.

269 TRIPLES      21 PREDICATES      81 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1005611613542 schema:about N08b7c66f7e0a4cf183675dee8296bc40
2 N10a847247c16443c8ca8d9f3013bd6aa
3 N2c0bceacde1e470ea160d193cf7844a0
4 N3c247c3a0d8648b6b4c2410f67a4c5ab
5 N6d72e640af674322a6761d7b4236bb47
6 N71195fdb43934e8eaf9df3f32ae21c38
7 N906925f29e704faf868336bddfbee1e9
8 N9d17766f71f34d6e93d8b6d7200af4d8
9 Nad8cb44a26004b91abada66d0aaaecd9
10 Nb1fa34902afd46d5b01e11362bb84acb
11 Nc5635e13dc18454aa26296342359302b
12 Nc766c1673bd443f68de96f652fe37447
13 Nca1a00b98d8a4b31a7dae6d03ce96bf7
14 Nd1cdc813d9cd4a008ac380871ae95d55
15 Nd2c2d2081b644bfe928b385087db0d31
16 Nd866b3bf8c044c409241db134bc94f01
17 Ndef87076f73c4c5092bb4a2d45907bf5
18 Nee9f6c6c573c42c99c5c326e74f66718
19 Nf8efa444413a4763b5a85ff47e89e773
20 anzsrc-for:06
21 anzsrc-for:0601
22 schema:author N133f0bbdcab7495981d7adba0899c3c5
23 schema:citation sg:pub.10.1023/a:1005461427250
24 sg:pub.10.1111/j.1572-0241.1999.876_e.x
25 https://app.dimensions.ai/details/publication/pub.1074474679
26 https://app.dimensions.ai/details/publication/pub.1074494550
27 https://app.dimensions.ai/details/publication/pub.1082473553
28 https://app.dimensions.ai/details/publication/pub.1082489147
29 https://app.dimensions.ai/details/publication/pub.1082636332
30 https://app.dimensions.ai/details/publication/pub.1083071650
31 https://app.dimensions.ai/details/publication/pub.1083356316
32 https://doi.org/10.1001/jama.272.1.65
33 https://doi.org/10.1002/(sici)1096-9098(199811)69:3<168::aid-jso9>3.0.co;2-0
34 https://doi.org/10.1006/abbi.1995.1130
35 https://doi.org/10.1016/0090-6980(94)90074-4
36 https://doi.org/10.1016/0092-8674(95)90127-2
37 https://doi.org/10.1016/s0016-5085(97)70003-9
38 https://doi.org/10.1016/s0016-5085(97)99999-6
39 https://doi.org/10.1016/s0065-2776(08)60430-7
40 https://doi.org/10.1016/s0092-8674(00)81433-6
41 https://doi.org/10.1046/j.1365-2567.1998.00646.x
42 https://doi.org/10.1053/gast.1997.v113.pm9322504
43 https://doi.org/10.1073/pnas.94.7.3336
44 https://doi.org/10.1074/jbc.273.44.28560
45 https://doi.org/10.1080/003655200750024515
46 https://doi.org/10.1084/jem.181.5.1661
47 https://doi.org/10.1084/jem.187.10.1659
48 https://doi.org/10.1093/jnci/89.12.863
49 https://doi.org/10.1111/j.1365-2036.1994.tb00274.x
50 https://doi.org/10.1111/j.1440-1746.1997.tb00469.x
51 https://doi.org/10.1136/gut.38.4.498
52 https://doi.org/10.1172/jci119535
53 https://doi.org/10.1172/jci119557
54 https://doi.org/10.1172/jci2466
55 https://doi.org/10.3109/00365519709060035
56 schema:datePublished 2000-12
57 schema:datePublishedReg 2000-12-01
58 schema:description Helicobacter pylori induces apoptosis and alters the proliferation of gastric mucosal epithelial cells. Cyclooxygenase-2 (COX-2), the inducible form of prostaglandin (PG) synthesis, is known to cause alteration in epithelial cell growth. The goal of this study was to determine whether COX-2 gene expression by H. pylori infection could influence gastric epithelial cell apoptosis. Expression of COX-2 mRNA and proteins was up-regulated in Hs746T gastric epithelial cell lines infected with H. pylori, when assessed by quantitative RT-PCR and western blot. Inhibition of COX-2 expression using NS-398, a specific COX-2 inhibitor, showed a significant increase of gastric epithelial cell apoptosis and caspase-3 activation in Hs746T cells infected with H. pylori. Moreover, the effect of NS-398 on H. pylori-induced apoptosis was reversed by the addition of PGE2. These results suggest that up-regulated COX-2 expression by H. pylori infection can inhibit apoptosis of gastric epithelial cells.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree false
62 schema:isPartOf N7fd17d1f26a24eeabc99cf2c7c8ddc03
63 Nfa53663019194b94a0a68184ef6afa14
64 sg:journal.1018525
65 schema:name Upregulated Cyclooxygenase-2 Inhibits Apoptosis of Human Gastric Epithelial Cells Infected with Helicobacter pylori
66 schema:pagination 2436-2443
67 schema:productId N01db3f8eaa2f42dca53b1b5106210828
68 N196bfae799864760b707cb4cb47eeea2
69 N43f224b6ca1a47658b5f8f5aad2abe54
70 Nb6585d6f762a434686dfdb5be14501b3
71 Nc2b487d2987f400ab765831955b5f466
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032505853
73 https://doi.org/10.1023/a:1005611613542
74 schema:sdDatePublished 2019-04-10T19:54
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher N9eb9a35bece741368ea32b0fa5dd8684
77 schema:url http://link.springer.com/10.1023/A:1005611613542
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N01db3f8eaa2f42dca53b1b5106210828 schema:name dimensions_id
82 schema:value pub.1032505853
83 rdf:type schema:PropertyValue
84 N08b7c66f7e0a4cf183675dee8296bc40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Cell Line
86 rdf:type schema:DefinedTerm
87 N10a847247c16443c8ca8d9f3013bd6aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Helicobacter pylori
89 rdf:type schema:DefinedTerm
90 N133f0bbdcab7495981d7adba0899c3c5 rdf:first sg:person.01064772272.15
91 rdf:rest N4909c89ad3894a8e9470388191f73693
92 N196bfae799864760b707cb4cb47eeea2 schema:name readcube_id
93 schema:value 9adad055d3cc8008d529fb377936b24e31f9da84ad0e98adb5889a5108bdc1f9
94 rdf:type schema:PropertyValue
95 N2c0bceacde1e470ea160d193cf7844a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Nitrobenzenes
97 rdf:type schema:DefinedTerm
98 N3c247c3a0d8648b6b4c2410f67a4c5ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Prostaglandin-Endoperoxide Synthases
100 rdf:type schema:DefinedTerm
101 N43f224b6ca1a47658b5f8f5aad2abe54 schema:name doi
102 schema:value 10.1023/a:1005611613542
103 rdf:type schema:PropertyValue
104 N4909c89ad3894a8e9470388191f73693 rdf:first sg:person.07514633567.21
105 rdf:rest Ne525ef15628f4ff090ece66a63fc92af
106 N6d72e640af674322a6761d7b4236bb47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Cyclooxygenase Inhibitors
108 rdf:type schema:DefinedTerm
109 N71195fdb43934e8eaf9df3f32ae21c38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Up-Regulation
111 rdf:type schema:DefinedTerm
112 N7fd17d1f26a24eeabc99cf2c7c8ddc03 schema:issueNumber 12
113 rdf:type schema:PublicationIssue
114 N906925f29e704faf868336bddfbee1e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Cells, Cultured
116 rdf:type schema:DefinedTerm
117 N9d17766f71f34d6e93d8b6d7200af4d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Isoenzymes
119 rdf:type schema:DefinedTerm
120 N9eb9a35bece741368ea32b0fa5dd8684 schema:name Springer Nature - SN SciGraph project
121 rdf:type schema:Organization
122 Nad8cb44a26004b91abada66d0aaaecd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Membrane Proteins
124 rdf:type schema:DefinedTerm
125 Nb1fa34902afd46d5b01e11362bb84acb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Humans
127 rdf:type schema:DefinedTerm
128 Nb40fb945f5f8443996cfef4f6beaa15d rdf:first sg:person.0714777622.22
129 rdf:rest rdf:nil
130 Nb6585d6f762a434686dfdb5be14501b3 schema:name pubmed_id
131 schema:value 11258572
132 rdf:type schema:PropertyValue
133 Nc2b487d2987f400ab765831955b5f466 schema:name nlm_unique_id
134 schema:value 7902782
135 rdf:type schema:PropertyValue
136 Nc5635e13dc18454aa26296342359302b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Sulfonamides
138 rdf:type schema:DefinedTerm
139 Nc766c1673bd443f68de96f652fe37447 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Cyclooxygenase 2 Inhibitors
141 rdf:type schema:DefinedTerm
142 Nc7ac0b70888c48a9bff216c5af6255ee rdf:first sg:person.01001342362.12
143 rdf:rest Nb40fb945f5f8443996cfef4f6beaa15d
144 Nca1a00b98d8a4b31a7dae6d03ce96bf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Dinoprostone
146 rdf:type schema:DefinedTerm
147 Nd1cdc813d9cd4a008ac380871ae95d55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cyclooxygenase 2
149 rdf:type schema:DefinedTerm
150 Nd2c2d2081b644bfe928b385087db0d31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Helicobacter Infections
152 rdf:type schema:DefinedTerm
153 Nd866b3bf8c044c409241db134bc94f01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Apoptosis
155 rdf:type schema:DefinedTerm
156 Ndef87076f73c4c5092bb4a2d45907bf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Stomach
158 rdf:type schema:DefinedTerm
159 Ne525ef15628f4ff090ece66a63fc92af rdf:first sg:person.01230372236.08
160 rdf:rest Nc7ac0b70888c48a9bff216c5af6255ee
161 Nee9f6c6c573c42c99c5c326e74f66718 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Epithelial Cells
163 rdf:type schema:DefinedTerm
164 Nf8efa444413a4763b5a85ff47e89e773 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Gene Expression Regulation, Bacterial
166 rdf:type schema:DefinedTerm
167 Nfa53663019194b94a0a68184ef6afa14 schema:volumeNumber 45
168 rdf:type schema:PublicationVolume
169 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
170 schema:name Biological Sciences
171 rdf:type schema:DefinedTerm
172 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
173 schema:name Biochemistry and Cell Biology
174 rdf:type schema:DefinedTerm
175 sg:journal.1018525 schema:issn 0163-2116
176 1573-2568
177 schema:name Digestive Diseases and Sciences
178 rdf:type schema:Periodical
179 sg:person.01001342362.12 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
180 schema:familyName Song
181 schema:givenName In Sung
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001342362.12
183 rdf:type schema:Person
184 sg:person.01064772272.15 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
185 schema:familyName Kim
186 schema:givenName Jung Mogg
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064772272.15
188 rdf:type schema:Person
189 sg:person.01230372236.08 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
190 schema:familyName Jung
191 schema:givenName Hyun Chae
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230372236.08
193 rdf:type schema:Person
194 sg:person.0714777622.22 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
195 schema:familyName Kim
196 schema:givenName Chung Yong
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714777622.22
198 rdf:type schema:Person
199 sg:person.07514633567.21 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
200 schema:familyName Kim
201 schema:givenName Joo Sung
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07514633567.21
203 rdf:type schema:Person
204 sg:pub.10.1023/a:1005461427250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037640828
205 https://doi.org/10.1023/a:1005461427250
206 rdf:type schema:CreativeWork
207 sg:pub.10.1111/j.1572-0241.1999.876_e.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007599619
208 https://doi.org/10.1111/j.1572-0241.1999.876_e.x
209 rdf:type schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1074474679 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1074494550 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1082473553 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1082489147 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1082636332 schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1083071650 schema:CreativeWork
216 https://app.dimensions.ai/details/publication/pub.1083356316 schema:CreativeWork
217 https://doi.org/10.1001/jama.272.1.65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054157307
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1002/(sici)1096-9098(199811)69:3<168::aid-jso9>3.0.co;2-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051628264
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1006/abbi.1995.1130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006192533
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/0090-6980(94)90074-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032269393
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/0092-8674(95)90127-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007200098
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0016-5085(97)70003-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030172768
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0016-5085(97)99999-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034415961
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s0065-2776(08)60430-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014523809
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/s0092-8674(00)81433-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034592591
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1046/j.1365-2567.1998.00646.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1056735829
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1053/gast.1997.v113.pm9322504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048674935
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1073/pnas.94.7.3336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038658027
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1074/jbc.273.44.28560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004151120
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1080/003655200750024515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033788438
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1084/jem.181.5.1661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003282493
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1084/jem.187.10.1659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007136353
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1093/jnci/89.12.863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047466918
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1111/j.1365-2036.1994.tb00274.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050028200
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1111/j.1440-1746.1997.tb00469.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030319399
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1136/gut.38.4.498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013844049
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1172/jci119535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025162614
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1172/jci119557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031458391
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1172/jci2466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006596958
262 rdf:type schema:CreativeWork
263 https://doi.org/10.3109/00365519709060035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023160932
264 rdf:type schema:CreativeWork
265 https://www.grid.ac/institutes/grid.412484.f schema:alternateName Seoul National University Hospital
266 schema:name Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
267 Department of Internal Medicine, the Liver Research Institute, The Institutes for Endemic Diseases and the Medical Research Center, Seoul National University College of Medicine, Seoul, Korea
268 Department of Microbiology and Institute of Biomedical Science, Hanyang University College of Medicine, Seoul, Korea
269 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...