Activation of the skeletal α-actin promoter during muscle regeneration View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-11

AUTHORS

Daniel R. Marsh, James A. Carson, Lynn N. Stewart, Frank W. Booth

ABSTRACT

Little is known conerning promoter regulation of genes in regenerating skeletal muscles. In young rats, recovery of muscle mass and protein content is complete within 21 days. During the initial 5–10 days of regeneration, mRNA abundance for IGF-I, myogenin and MyoD have been shown to be dramatically increased. The skeletal α-actin promoter contains E box and serum response element (SRE) regulatory regions which are directly or indirectly activated by myogenin (or MyoD) and IGF-I proteins, respectively. We hypothesized that the skeletal α-actin promoter activity would increase during muscle regeneration, and that this induction would occur before muscle protein content returned to normal. Total protein content and the percentage content of skeletal α-actin protein was diminished at 4 and 8 days and re-accumulation had largely occurred by 16 days post-bupivacaine injection. Skeletal α- actin mRNA per whole muscle was decreased at day 8, and thereafter returned to control values. During regeneration at day 8, luciferase activity (a reporter of promoter activity) directed by −424 skeletal α-actin and −99 skeletal α-actin promoter constructs was increased by 700% and 250% respectively; however, at day 16, skeletal α-actin promoter activities were similar to control values. Thus, initial activation of the skeletal α- actin promoter is associated with regeneration of skeletal muscle, despite not being sustained during the later stages of regrowth. The proximal SRE of the skeletal α-actin promoter was not sufficient to confer a regeneration-induced promoter activation, despite increased serum response factor protein binding to this regulatory element in electrophoretic mobility shift assays. Skeletal α-actin promoter induction during regeneration is due to a combination of regulatory elements, at least including the SRE and E box. © Kluwer Academic Publishers. More... »

PAGES

897-907

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1005485400448

DOI

http://dx.doi.org/10.1023/a:1005485400448

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042759755

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10047989


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Actins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anesthetics, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bupivacaine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Choline O-Acetyltransferase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Reporter", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Luciferases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Skeletal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ Size", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Regeneration", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Marsh", 
        "givenName": "Daniel R.", 
        "id": "sg:person.01102570477.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102570477.61"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Carson", 
        "givenName": "James A.", 
        "id": "sg:person.012376023762.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012376023762.35"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Stewart", 
        "givenName": "Lynn N.", 
        "type": "Person"
      }, 
      {
        "familyName": "Booth", 
        "givenName": "Frank W.", 
        "id": "sg:person.01147120730.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147120730.32"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/298857a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048082926", 
          "https://doi.org/10.1038/298857a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00227821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034005931", 
          "https://doi.org/10.1007/bf00227821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1016039330870", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006850729", 
          "https://doi.org/10.1023/a:1016039330870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/303348a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012182205", 
          "https://doi.org/10.1038/303348a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00121163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003965865", 
          "https://doi.org/10.1007/bf00121163"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-11", 
    "datePublishedReg": "1998-11-01", 
    "description": "Little is known conerning promoter regulation of genes in regenerating skeletal muscles. In young rats, recovery of muscle mass and protein content is complete within 21 days. During the initial 5\u201310 days of regeneration, mRNA abundance for IGF-I, myogenin and MyoD have been shown to be dramatically increased. The skeletal \u03b1-actin promoter contains E box and serum response element (SRE) regulatory regions which are directly or indirectly activated by myogenin (or MyoD) and IGF-I proteins, respectively. We hypothesized that the skeletal \u03b1-actin promoter activity would increase during muscle regeneration, and that this induction would occur before muscle protein content returned to normal. Total protein content and the percentage content of skeletal \u03b1-actin protein was diminished at 4 and 8 days and re-accumulation had largely occurred by 16 days post-bupivacaine injection. Skeletal \u03b1- actin mRNA per whole muscle was decreased at day 8, and thereafter returned to control values. During regeneration at day 8, luciferase activity (a reporter of promoter activity) directed by \u2212424 skeletal \u03b1-actin and \u221299 skeletal \u03b1-actin promoter constructs was increased by 700% and 250% respectively; however, at day 16, skeletal \u03b1-actin promoter activities were similar to control values. Thus, initial activation of the skeletal \u03b1- actin promoter is associated with regeneration of skeletal muscle, despite not being sustained during the later stages of regrowth. The proximal SRE of the skeletal \u03b1-actin promoter was not sufficient to confer a regeneration-induced promoter activation, despite increased serum response factor protein binding to this regulatory element in electrophoretic mobility shift assays. Skeletal \u03b1-actin promoter induction during regeneration is due to a combination of regulatory elements, at least including the SRE and E box. \u00a9 Kluwer Academic Publishers.", 
    "genre": "article", 
    "id": "sg:pub.10.1023/a:1005485400448", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2463369", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1091334", 
        "issn": [
          "0142-4319", 
          "1573-2657"
        ], 
        "name": "Journal of Muscle Research and Cell Motility", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "actin promoter activity", 
      "actin promoter", 
      "regulatory elements", 
      "serum response factor (SRF) protein", 
      "promoter activity", 
      "electrophoretic mobility shift assays", 
      "muscle regeneration", 
      "mobility shift assays", 
      "protein content", 
      "skeletal \u03b1", 
      "skeletal muscle", 
      "promoter regulation", 
      "regulatory region", 
      "shift assays", 
      "actin protein", 
      "promoter activation", 
      "promoter constructs", 
      "promoter induction", 
      "actin mRNA", 
      "factor protein", 
      "promoter", 
      "days of regeneration", 
      "luciferase activity", 
      "mRNA abundance", 
      "total protein content", 
      "muscle protein content", 
      "myogenin", 
      "protein", 
      "regeneration", 
      "activation", 
      "initial activation", 
      "later stages", 
      "MyoD", 
      "induction", 
      "genes", 
      "abundance", 
      "mRNA", 
      "regulation", 
      "activity", 
      "muscle mass", 
      "SRE", 
      "box", 
      "assays", 
      "muscle", 
      "whole muscle", 
      "IGF", 
      "content", 
      "day 8", 
      "regrowth", 
      "constructs", 
      "region", 
      "day 16", 
      "elements", 
      "stage", 
      "mass", 
      "days", 
      "combination", 
      "Publisher", 
      "percentage content", 
      "control values", 
      "recovery", 
      "values", 
      "young rats", 
      "rats", 
      "Kluwer Academic Publishers", 
      "injection", 
      "academic publishers"
    ], 
    "name": "Activation of the skeletal \u03b1-actin promoter during muscle regeneration", 
    "pagination": "897-907", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042759755"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1023/a:1005485400448"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10047989"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1023/a:1005485400448", 
      "https://app.dimensions.ai/details/publication/pub.1042759755"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-10T09:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_305.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1023/a:1005485400448"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1023/a:1005485400448'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1023/a:1005485400448'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1023/a:1005485400448'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1023/a:1005485400448'


 

This table displays all metadata directly associated to this object as RDF triples.

240 TRIPLES      22 PREDICATES      118 URIs      105 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1023/a:1005485400448 schema:about N00f752936d3d4dadbec475d4cdaaa572
2 N14405870291241eead59640e92d1171f
3 N1bd83a8eee5445429761b13ba561bdf0
4 N1d63b35aec374478a27e74dc2281d771
5 N4660036f20334efaad9e7cb375e34dee
6 N56e78f3df1c348ef8eb1f9600754ae5b
7 N657ac68db660449a9a65aad6284fe3a7
8 N67c0b7d896714a9ebcaf8dcf4c0a3504
9 N72f6dd43873849899b6b461a05143289
10 N90fcc74f6dbc4646821340a46e856c37
11 N927aa5f2121b401ebaf1aa9c66d8f241
12 N95a1fc9f4b854c268c07fe2aa80ee362
13 N991455f8ed75415d9dae46542bf14627
14 Na82793b85ed04b45a54912541649a224
15 Nb8fd3be6b8c64fb384417a19b26f83e9
16 Nc04472e393504003b2efb8006681a43e
17 Ndacaecf0bfc246b69e9870a0bf7da7c4
18 Ne65655f7436249848219296694c91ef0
19 Nf8b53d9d986342aaaba1b191beb4d66c
20 anzsrc-for:06
21 anzsrc-for:0601
22 schema:author Nf45333d5b0554fdd9ebf95a8c00f0448
23 schema:citation sg:pub.10.1007/bf00121163
24 sg:pub.10.1007/bf00227821
25 sg:pub.10.1023/a:1016039330870
26 sg:pub.10.1038/298857a0
27 sg:pub.10.1038/303348a0
28 schema:datePublished 1998-11
29 schema:datePublishedReg 1998-11-01
30 schema:description Little is known conerning promoter regulation of genes in regenerating skeletal muscles. In young rats, recovery of muscle mass and protein content is complete within 21 days. During the initial 5–10 days of regeneration, mRNA abundance for IGF-I, myogenin and MyoD have been shown to be dramatically increased. The skeletal α-actin promoter contains E box and serum response element (SRE) regulatory regions which are directly or indirectly activated by myogenin (or MyoD) and IGF-I proteins, respectively. We hypothesized that the skeletal α-actin promoter activity would increase during muscle regeneration, and that this induction would occur before muscle protein content returned to normal. Total protein content and the percentage content of skeletal α-actin protein was diminished at 4 and 8 days and re-accumulation had largely occurred by 16 days post-bupivacaine injection. Skeletal α- actin mRNA per whole muscle was decreased at day 8, and thereafter returned to control values. During regeneration at day 8, luciferase activity (a reporter of promoter activity) directed by −424 skeletal α-actin and −99 skeletal α-actin promoter constructs was increased by 700% and 250% respectively; however, at day 16, skeletal α-actin promoter activities were similar to control values. Thus, initial activation of the skeletal α- actin promoter is associated with regeneration of skeletal muscle, despite not being sustained during the later stages of regrowth. The proximal SRE of the skeletal α-actin promoter was not sufficient to confer a regeneration-induced promoter activation, despite increased serum response factor protein binding to this regulatory element in electrophoretic mobility shift assays. Skeletal α-actin promoter induction during regeneration is due to a combination of regulatory elements, at least including the SRE and E box. © Kluwer Academic Publishers.
31 schema:genre article
32 schema:inLanguage en
33 schema:isAccessibleForFree false
34 schema:isPartOf N637724698f044bce80a218ee7fe6bfeb
35 Nc7d80c0ec25249459bcd86f667f15c15
36 sg:journal.1091334
37 schema:keywords IGF
38 Kluwer Academic Publishers
39 MyoD
40 Publisher
41 SRE
42 abundance
43 academic publishers
44 actin mRNA
45 actin promoter
46 actin promoter activity
47 actin protein
48 activation
49 activity
50 assays
51 box
52 combination
53 constructs
54 content
55 control values
56 day 16
57 day 8
58 days
59 days of regeneration
60 electrophoretic mobility shift assays
61 elements
62 factor protein
63 genes
64 induction
65 initial activation
66 injection
67 later stages
68 luciferase activity
69 mRNA
70 mRNA abundance
71 mass
72 mobility shift assays
73 muscle
74 muscle mass
75 muscle protein content
76 muscle regeneration
77 myogenin
78 percentage content
79 promoter
80 promoter activation
81 promoter activity
82 promoter constructs
83 promoter induction
84 promoter regulation
85 protein
86 protein content
87 rats
88 recovery
89 regeneration
90 region
91 regrowth
92 regulation
93 regulatory elements
94 regulatory region
95 serum response factor (SRF) protein
96 shift assays
97 skeletal muscle
98 skeletal α
99 stage
100 total protein content
101 values
102 whole muscle
103 young rats
104 schema:name Activation of the skeletal α-actin promoter during muscle regeneration
105 schema:pagination 897-907
106 schema:productId N2825b1f1a8a542baad4d85c58da91a45
107 Nb18862fa44214b8694bfbf72b66d0079
108 Nd9eb22ec688441dd9fa6f2cd6edb6b08
109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042759755
110 https://doi.org/10.1023/a:1005485400448
111 schema:sdDatePublished 2022-05-10T09:46
112 schema:sdLicense https://scigraph.springernature.com/explorer/license/
113 schema:sdPublisher N3bfe4c4a19ed426fb35320bf935df8e1
114 schema:url https://doi.org/10.1023/a:1005485400448
115 sgo:license sg:explorer/license/
116 sgo:sdDataset articles
117 rdf:type schema:ScholarlyArticle
118 N00f752936d3d4dadbec475d4cdaaa572 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Promoter Regions, Genetic
120 rdf:type schema:DefinedTerm
121 N0d8493a0ac28460eb277dce1f32a31a4 rdf:first sg:person.012376023762.35
122 rdf:rest Nc4d8295f90054508824e0c49d23d4f87
123 N14405870291241eead59640e92d1171f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Plasmids
125 rdf:type schema:DefinedTerm
126 N15b6fa8a561c49e3b301117ebc40afc9 schema:familyName Stewart
127 schema:givenName Lynn N.
128 rdf:type schema:Person
129 N1bd83a8eee5445429761b13ba561bdf0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Gene Deletion
131 rdf:type schema:DefinedTerm
132 N1d63b35aec374478a27e74dc2281d771 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Actins
134 rdf:type schema:DefinedTerm
135 N2825b1f1a8a542baad4d85c58da91a45 schema:name doi
136 schema:value 10.1023/a:1005485400448
137 rdf:type schema:PropertyValue
138 N3bfe4c4a19ed426fb35320bf935df8e1 schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 N4660036f20334efaad9e7cb375e34dee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Luciferases
142 rdf:type schema:DefinedTerm
143 N56e78f3df1c348ef8eb1f9600754ae5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Organ Size
145 rdf:type schema:DefinedTerm
146 N637724698f044bce80a218ee7fe6bfeb schema:volumeNumber 19
147 rdf:type schema:PublicationVolume
148 N657ac68db660449a9a65aad6284fe3a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Genes, Reporter
150 rdf:type schema:DefinedTerm
151 N67c0b7d896714a9ebcaf8dcf4c0a3504 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Muscle, Skeletal
153 rdf:type schema:DefinedTerm
154 N72f6dd43873849899b6b461a05143289 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name RNA, Messenger
156 rdf:type schema:DefinedTerm
157 N90fcc74f6dbc4646821340a46e856c37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Regeneration
159 rdf:type schema:DefinedTerm
160 N927aa5f2121b401ebaf1aa9c66d8f241 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Anesthetics, Local
162 rdf:type schema:DefinedTerm
163 N95a1fc9f4b854c268c07fe2aa80ee362 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Animals
165 rdf:type schema:DefinedTerm
166 N991455f8ed75415d9dae46542bf14627 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Protein Binding
168 rdf:type schema:DefinedTerm
169 N99fcb40f43c84c64a87398529e124b4a rdf:first sg:person.01147120730.32
170 rdf:rest rdf:nil
171 Na82793b85ed04b45a54912541649a224 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Male
173 rdf:type schema:DefinedTerm
174 Nb18862fa44214b8694bfbf72b66d0079 schema:name dimensions_id
175 schema:value pub.1042759755
176 rdf:type schema:PropertyValue
177 Nb8fd3be6b8c64fb384417a19b26f83e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Bupivacaine
179 rdf:type schema:DefinedTerm
180 Nc04472e393504003b2efb8006681a43e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Choline O-Acetyltransferase
182 rdf:type schema:DefinedTerm
183 Nc4d8295f90054508824e0c49d23d4f87 rdf:first N15b6fa8a561c49e3b301117ebc40afc9
184 rdf:rest N99fcb40f43c84c64a87398529e124b4a
185 Nc7d80c0ec25249459bcd86f667f15c15 schema:issueNumber 8
186 rdf:type schema:PublicationIssue
187 Nd9eb22ec688441dd9fa6f2cd6edb6b08 schema:name pubmed_id
188 schema:value 10047989
189 rdf:type schema:PropertyValue
190 Ndacaecf0bfc246b69e9870a0bf7da7c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Rats, Sprague-Dawley
192 rdf:type schema:DefinedTerm
193 Ne65655f7436249848219296694c91ef0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Rats
195 rdf:type schema:DefinedTerm
196 Nf45333d5b0554fdd9ebf95a8c00f0448 rdf:first sg:person.01102570477.61
197 rdf:rest N0d8493a0ac28460eb277dce1f32a31a4
198 Nf8b53d9d986342aaaba1b191beb4d66c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Gene Expression Regulation
200 rdf:type schema:DefinedTerm
201 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
202 schema:name Biological Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
205 schema:name Biochemistry and Cell Biology
206 rdf:type schema:DefinedTerm
207 sg:grant.2463369 http://pending.schema.org/fundedItem sg:pub.10.1023/a:1005485400448
208 rdf:type schema:MonetaryGrant
209 sg:journal.1091334 schema:issn 0142-4319
210 1573-2657
211 schema:name Journal of Muscle Research and Cell Motility
212 schema:publisher Springer Nature
213 rdf:type schema:Periodical
214 sg:person.01102570477.61 schema:familyName Marsh
215 schema:givenName Daniel R.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102570477.61
217 rdf:type schema:Person
218 sg:person.01147120730.32 schema:familyName Booth
219 schema:givenName Frank W.
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147120730.32
221 rdf:type schema:Person
222 sg:person.012376023762.35 schema:familyName Carson
223 schema:givenName James A.
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012376023762.35
225 rdf:type schema:Person
226 sg:pub.10.1007/bf00121163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003965865
227 https://doi.org/10.1007/bf00121163
228 rdf:type schema:CreativeWork
229 sg:pub.10.1007/bf00227821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034005931
230 https://doi.org/10.1007/bf00227821
231 rdf:type schema:CreativeWork
232 sg:pub.10.1023/a:1016039330870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006850729
233 https://doi.org/10.1023/a:1016039330870
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/298857a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048082926
236 https://doi.org/10.1038/298857a0
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/303348a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012182205
239 https://doi.org/10.1038/303348a0
240 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...