Helicobacter pylori Water-Soluble Surface Proteins Activate Human Neutrophils and Up-Regulate Expression of CXC Chemokines View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-01

AUTHORS

Joo Sung Kim, Hyun Chae Jung, Jung Mogg Kim, In Sung Song, Chung Yong Kim

ABSTRACT

To elucidate the mechanisms of the persistent neutrophil recruitment in H. pylori-infected gastric mucosa, we evaluated the activation of human neutrophils and CXC chemokine expression in neutrophils by H. pylori water-soluble surface proteins. H. pylori water extract (HPWE) was prepared from a supernatant of the H. pylori suspension in distilled water. After neutrophils were stimulated with HPWE, the mobilization of intracellular free calcium, the expression of lymphocyte function-associated antigen-1β, and the secretion of myeloperoxidase (MPO) were enhanced in the neutrophils. In H. pylori-infected gastric mucosa, transendothelial and transepithelial migration of neutrophils were observed by electron microscopy and mucosal MPO levels were elevated. Up-regulation of the expression of interleukin-8 (IL-8) and growth-related oncogenes (GROs; GROα, GROβ and GROγ) mRNA and protein in neutrophils by HPWE was demonstrated by quantitative reverse transcription–polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. In conclusion, H. pylori-induced neutrophil recruitment may be mediated by CXC chemokines which are expressed by neutrophils activated by H. pylori water-soluble surface proteins. More... »

PAGES

83-92

References to SciGraph publications

  • 1995-06. Mechanism ofhelicobacter pylori-associated gastric mucosal injury in DIGESTIVE DISEASES AND SCIENCES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1023/a:1005461427250

    DOI

    http://dx.doi.org/10.1023/a:1005461427250

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037640828

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10695618


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