Decreased platelet membrane anisotropy in patients with adrenoleukodystrophy treated with erucic acid (22:1)-rich triglycerides View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-03

AUTHORS

S. Stöckler, C. Opper, A. Greinacher, D. H. Hunneman, G. C. Korenke, C. J. Unkrig, F. Hanefeld

ABSTRACT

Low platelet count and bleeding diathesis have been observed in patients with adrenoleukodystrophy (ALD) treated with erucic acid (22:1)-rich triglycerides ("Lorenzo's oil'). To investigate possible alterations of biophysical membrane properties, we measured platelet membrane anisotropy, which is inversely related to membrane fluidity, in 16 patients with and in 3 patients without treatment. In patients on treatment, platelet membrane anisotropy was significantly decreased. Additionally, we found increased platelet concentrations of 22:1 and compromised in vitro platelet aggregation response. The decrease of platelet membrane anisotropy is probably a main cause of bleeding diathesis. Long-term haematological side-effects must be considered in ALD patients treated with Lorenzo's oil. More... »

PAGES

54-58

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1005309623452

DOI

http://dx.doi.org/10.1023/a:1005309623452

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053116594

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9061568


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