Neuroprotective Properties of Nootropic Dipeptide GVS-111 in in Vitro Oxygen-Glucose Deprivation, Glutamate Toxicity and Oxidative Stress View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-10

AUTHORS

N. A. Andreeva, E. V. Stel'mashuk, N. K. Isaev, R. U. Ostrovskaya, T. A. Gudasheva, I. V. Viktorov

ABSTRACT

Argon anoxia and glucose deprivation were used for modeling of ischemic damage in the cultures of cerebellar granule cells. Protective effect of peptide piracetam analogue GVS-111 was demonstrated. GVS-111 prevented neurodegeneration induced by glutamate and oxidative stress. In contrast to GVS-111, piracetam did not attenuate neurocytotoxic effect of glutamate.

PAGES

969-972

Identifiers

URI

http://scigraph.springernature.com/pub.10.1023/a:1002828707337

DOI

http://dx.doi.org/10.1023/a:1002828707337

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035854174

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11177296


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